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Whole-genome resequencing of wild and domestic sheep identifies genes associated with morphological and agronomic traits

X. Li, J. Yang, M. Shen, XL. Xie, GJ. Liu, YX. Xu, FH. Lv, H. Yang, YL. Yang, CB. Liu, P. Zhou, PC. Wan, YS. Zhang, L. Gao, JQ. Yang, WH. Pi, YL. Ren, ZQ. Shen, F. Wang, J. Deng, SS. Xu, H. Salehian-Dehkordi, E. Hehua, A. Esmailizadeh, M....

. 2020 ; 11 (1) : 2815. [pub] 20200604

Jazyk angličtina Země Velká Británie

Typ dokumentu časopisecké články, práce podpořená grantem

Perzistentní odkaz   https://www.medvik.cz/link/bmc20024965

Understanding the genetic changes underlying phenotypic variation in sheep (Ovis aries) may facilitate our efforts towards further improvement. Here, we report the deep resequencing of 248 sheep including the wild ancestor (O. orientalis), landraces, and improved breeds. We explored the sheep variome and selection signatures. We detected genomic regions harboring genes associated with distinct morphological and agronomic traits, which may be past and potential future targets of domestication, breeding, and selection. Furthermore, we found non-synonymous mutations in a set of plausible candidate genes and significant differences in their allele frequency distributions across breeds. We identified PDGFD as a likely causal gene for fat deposition in the tails of sheep through transcriptome, RT-PCR, qPCR, and Western blot analyses. Our results provide insights into the demographic history of sheep and a valuable genomic resource for future genetic studies and improved genome-assisted breeding of sheep and other domestic animals.

Animal Production and Health Laboratory Joint FAO IAEA Division of Nuclear Techniques in Food and Agriculture International Atomic Energy Agency Vienna Austria

CAAS ILRI Joint Laboratory on Livestock and Forage Genetic Resources Institute of Animal Science Chinese Academy of Agricultural Sciences Nairobi Kenya

CAS Key Laboratory of Animal Ecology and Conservation Biology Institute of Zoology Chinese Academy of Sciences Beijing 100049 China

CAS Key Laboratory of Animal Ecology and Conservation Biology Institute of Zoology Chinese Academy of Sciences Beijing 100101 China College of Animal Science and Technology China Agricultural University Beijing 100193 China

CAS Key Laboratory of Animal Ecology and Conservation Biology Institute of Zoology Chinese Academy of Sciences Beijing 100101 China College of Animal Science and Technology Sichuan Agricultural University Chengdu 611130 China

CSIRO Livestock Industries St Lucia Brisbane QLD Australia

Department of Animal Science Faculty of Agriculture Shahid Bahonar University of Kerman Kerman Iran

Department of Biological Sciences University of Alberta Edmonton Alberta T6G 2E9 Canada

Department of Microbial Cellular and Molecular Biology Addis Ababa University Addis Ababa Ethiopia LiveGene Program International Livestock Research Institute Addis Ababa Ethiopia

Faculty of Veterinary Medicine Utrecht University Utrecht the Netherlands

Grass Feeding Livestock Engineering Technology Research Center Ningxia Academy of Agriculture and Forestry Sciences Yinchuan China

Institute of Animal Breeding and Genetics Justus Liebig University Giessen Germany

Institute of Animal Husbandry and Veterinary Medicine Xinjiang Academy of Agricultural and Reclamation Sciences Shihezi 832000 China State Key Laboratory of Sheep Genetic Improvement and Healthy Breeding Xinjiang Academy of Agricultural and Reclamation Sciences Shihezi 832000 China

Institute of Molecular Genetics of the ASCR v v i Vídeňská 1083 142 20 Prague 4 Czech Republic

Institute of Sheep and Goat Science Nanjing Agricultural University Nanjing 210095 China

LiveGene Program International Livestock Research Institute Addis Ababa Ethiopia School of Life Sciences University of Nottingham University Park Nottingham NG7 2RD UK Center for Tropical Livestock Genetics and Health the Roslin Institute University of Edinburgh Easter Bush Midlothian EH25 9RG Scotland UK

Novogene Bioinformatics Institute Beijing 100083 China

Production Systems Natural Resources Institute Finland FI 31600 Jokioinen Finland

School of Biosciences Cardiff University Cathays Park Cardiff CF10 3AX Wales UK Sustainable Places Research Institute Cardiff University CF10 3BA Cardiff Wales UK

Shandong Binzhou Academy of Animal Science and Veterinary Medicine Binzhou 256600 China

Small Ruminant Genomics International Centre for Agricultural Research in the Dry Areas Addis Ababa Ethiopia

Citace poskytuje Crossref.org

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