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Genome-wide association study identifies 32 novel breast cancer susceptibility loci from overall and subtype-specific analyses
H. Zhang, TU. Ahearn, J. Lecarpentier, D. Barnes, J. Beesley, G. Qi, X. Jiang, TA. O'Mara, N. Zhao, MK. Bolla, AM. Dunning, J. Dennis, Q. Wang, ZA. Ful, K. Aittomäki, IL. Andrulis, H. Anton-Culver, V. Arndt, KJ. Aronson, BK. Arun, PL. Auer, J....
Language English Country United States
Document type Journal Article, Meta-Analysis, Research Support, N.I.H., Extramural, Research Support, N.I.H., Intramural, Research Support, Non-U.S. Gov't
Persistent link
https://www.medvik.cz/link/bmc20024988
Grant support
U19 CA148112
NCI NIH HHS - United States
C1287/A10710
Cancer Research UK - United Kingdom
C1287/A16563
Cancer Research UK - United Kingdom
C12292/A11174
Cancer Research UK - United Kingdom
R01 HG010480
NHGRI NIH HHS - United States
U19 CA148065
NCI NIH HHS - United States
C12292/A20861
Cancer Research UK - United Kingdom
GPH-129344
CIHR - Canada
C1287/A10118
Cancer Research UK - United Kingdom
U19 CA148537
NCI NIH HHS - United States
HHSN268201200008I
NHLBI NIH HHS - United States
Online
Full text
NLK
ProQuest Central
from 2000-01-01 to 1 year ago
Health & Medicine (ProQuest)
from 2000-01-01 to 1 year ago
Public Health Database (ProQuest)
from 2000-01-01 to 1 year ago
- MeSH
- Genome-Wide Association Study * MeSH
- Genetic Predisposition to Disease MeSH
- Humans MeSH
- Mutation MeSH
- Breast Neoplasms genetics pathology MeSH
- BRCA1 Protein genetics MeSH
- Case-Control Studies MeSH
- Triple Negative Breast Neoplasms genetics pathology MeSH
- Linkage Disequilibrium MeSH
- Check Tag
- Humans MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Meta-Analysis MeSH
- Research Support, Non-U.S. Gov't MeSH
- Research Support, N.I.H., Extramural MeSH
- Research Support, N.I.H., Intramural MeSH
Breast cancer susceptibility variants frequently show heterogeneity in associations by tumor subtype1-3. To identify novel loci, we performed a genome-wide association study including 133,384 breast cancer cases and 113,789 controls, plus 18,908 BRCA1 mutation carriers (9,414 with breast cancer) of European ancestry, using both standard and novel methodologies that account for underlying tumor heterogeneity by estrogen receptor, progesterone receptor and human epidermal growth factor receptor 2 status and tumor grade. We identified 32 novel susceptibility loci (P < 5.0 × 10-8), 15 of which showed evidence for associations with at least one tumor feature (false discovery rate < 0.05). Five loci showed associations (P < 0.05) in opposite directions between luminal and non-luminal subtypes. In silico analyses showed that these five loci contained cell-specific enhancers that differed between normal luminal and basal mammary cells. The genetic correlations between five intrinsic-like subtypes ranged from 0.35 to 0.80. The proportion of genome-wide chip heritability explained by all known susceptibility loci was 54.2% for luminal A-like disease and 37.6% for triple-negative disease. The odds ratios of polygenic risk scores, which included 330 variants, for the highest 1% of quantiles compared with middle quantiles were 5.63 and 3.02 for luminal A-like and triple-negative disease, respectively. These findings provide an improved understanding of genetic predisposition to breast cancer subtypes and will inform the development of subtype-specific polygenic risk scores.
Academic Unit of Pathology Department of Neuroscience University of Sheffield Sheffield UK
Behavioral and Epidemiology Research Group American Cancer Society Atlanta GA USA
Bioscience Department Faculty of Medicine Universidad de la Sabana Chia Colombia
Cancer Genetics and Prevention Program University of California San Francisco San Francisco CA USA
Cancer Prevention Program Fred Hutchinson Cancer Research Center Seattle WA USA
Cancer Risk and Prevention Clinic Dana Farber Cancer Institute Boston MA USA
Cancer Sciences Academic Unit Faculty of Medicine University of Southampton Southampton UK
Center for Genomic Medicine Rigshospitalet Copenhagen University Hospital Copenhagen Denmark
Center for Medical Genetics NorthShore University HealthSystem Evanston IL USA
Centre for Cancer Genetic Epidemiology Department of Oncology University of Cambridge Cambridge UK
Centre for Cancer Genetic Epidemiology University of Cambridge Cambridge UK
Centre for Cancer Research and Cell Biology Queen's University Belfast Belfast Northern Ireland UK
Centre for Medical Genetics Ghent University Ghent Belgium
Centro de Investigación Biomédica en Red de Enfermedades Raras Valencia Spain
Chronic Disease Epidemiology Yale School of Public Health New Haven CT USA
Clinical Cancer Genomics City of Hope Duarte CA USA
Clinical Genetics Guy's and St Thomas' NHS Foundation Trust London UK
Clinical Genetics Karolinska Institutet Stockholm Sweden
Department of Anatomical Pathology The Alfred Hospital Melbourne Victoria Australia
Department of Biostatistics Johns Hopkins Bloomberg School of Public Health Baltimore MD USA
Department of Breast Medical Oncology University of Texas MD Anderson Cancer Center Houston TX USA
Department of Cancer Biology and Genetics The Ohio State University Columbus OH USA
Department of Cancer Epidemiology and Genetics Masaryk Memorial Cancer Institute Brno Czech Republic
Department of Clinical Genetics Erasmus University Medical Center Rotterdam the Netherlands
Department of Clinical Genetics Fox Chase Cancer Center Philadelphia PA USA
Department of Clinical Genetics Helsinki University Hospital University of Helsinki Helsinki Finland
Department of Clinical Genetics Odense University Hospital Odense Denmark
Department of Epidemiology Mailman School of Public Health Columbia University New York NY USA
Department of Epidemiology The Netherlands Cancer Institute Amsterdam the Netherlands
Department of Genetics and Fundamental Medicine Bashkir State Medical University Ufa Russia
Department of Genetics and Pathology Pomeranian Medical University Szczecin Poland
Department of Genetics Portuguese Oncology Institute Porto Portugal
Department of Genetics University of Pretoria Pretoria South Africa
Department of Gynaecology and Obstetrics University Hospital Ulm Ulm Germany
Department of Gynecology and Obstetrics Helios Clinics Berlin Buch Berlin Germany
Department of Gynecology and Obstetrics Ludwig Maximilian University of Munich Munich Germany
Department of Health Science Research Division of Epidemiology Mayo Clinic Rochester MN USA
Department of Health Sciences Research Mayo Clinic College of Medicine Jacksonville FL USA
Department of Internal Medicine Evangelische Kliniken Bonn Johanniter Krankenhaus Bonn Germany
Department of Laboratory Medicine and Pathology Mayo Clinic Rochester MN USA
Department of Medical Epidemiology and Biostatistics Karolinska Institutet Stockholm Sweden
Department of Medical Oncology Beth Israel Deaconess Medical Center Boston MA USA
Department of Medicine Huntsman Cancer Institute Salt Lake City UT USA
Department of Molecular Genetics National Institute of Oncology Budapest Hungary
Department of Oncology Lombardi Comprehensive Cancer Center Georgetown University Washington DC USA
Department of Oncology Lund University and Skåne University Hospital Lund Sweden
Department of Oncology University Hospital of Larissa Larissa Greece
Department of Pathology and Laboratory Medicine Kansas University Medical Center Kansas City KS USA
Department of Pathology Leiden University Medical Center Leiden the Netherlands
Department of Population Sciences Beckman Research Institute of City of Hope Duarte CA USA
Department of Radiation Oncology Hannover Medical School Hannover Germany
Department of Surgery Leiden University Medical Center Leiden the Netherlands
Department of Surgical Pathology Zealand University Hospital Slagelse Denmark
Department of Women's Health University of Tübingen Tübingen Germany
Departments of Pediatrics and Medicine Columbia University New York NY USA
Division of Cancer Epidemiology DKFZ Heidelberg Germany
Division of Cancer Prevention and Genetics European Institute of Oncology IRCCS Milan Italy
Division of Cancer Sciences University of Manchester Manchester UK
Division of Genetics and Epidemiology The Institute of Cancer Research London UK
Epidemiology Branch National Institute of Environmental Health Sciences NIH Durham NC USA
Faculty of Medicine University of Southampton Southampton UK
Genetic Epidemiology of Cancer Team INSERM U900 Paris France
Genome Diagnostics Program IFOM FIRC Institute of Molecular Oncology Milan Italy
Gynaecology Research Unit Hannover Medical School Hannover Germany
Human Cancer Genetics Programme Spanish National Cancer Research Centre Madrid Spain
Immunology and Molecular Oncology Unit Veneto Institute of Oncology IRCCS Padua Italy
Institute of Pathology Staedtisches Klinikum Karlsruhe Karlsruhe Germany
Latvian Biomedical Research and Study Centre Riga Latvia
Lombardi Comprehensive Cancer Center Georgetown University Washington DC USA
Magee Womens Hospital University of Pittsburgh School of Medicine Pittsburgh PA USA
Molecular Genetics of Breast Cancer DKFZ Heidelberg Germany
N N Petrov Institute of Oncology St Petersburg Russia
National Human Genome Research Institute National Cancer Institute Bethesda MD USA
NRG Oncology Statistics and Data Management Center Roswell Park Cancer Institute Buffalo NY USA
Oncogenetics Group Vall d'Hebron Institute of Oncology Barcelona Spain
Parkville Familial Cancer Centre Peter MacCallum Cancer Center Melbourne Victoria Australia
Research Oncology Guy's Hospital King's College London London UK
Saarland Cancer Registry Saarbrücken Germany
The Susanne Levy Gertner Oncogenetics Unit Chaim Sheba Medical Center Ramat Gan Israel
Unit of Molecular Bases of Genetic Risk and Genetic Testing Department of Research INT Milan Italy
Université Paris Sorbonne Cité INSERM UMR S1147 Paris France
Waukesha Memorial Hospital Pro Health Care Waukesha WI USA
Westmead Institute for Medical Research University of Sydney Sydney New South Wales Australia
References provided by Crossref.org
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- $a Breast cancer susceptibility variants frequently show heterogeneity in associations by tumor subtype1-3. To identify novel loci, we performed a genome-wide association study including 133,384 breast cancer cases and 113,789 controls, plus 18,908 BRCA1 mutation carriers (9,414 with breast cancer) of European ancestry, using both standard and novel methodologies that account for underlying tumor heterogeneity by estrogen receptor, progesterone receptor and human epidermal growth factor receptor 2 status and tumor grade. We identified 32 novel susceptibility loci (P < 5.0 × 10-8), 15 of which showed evidence for associations with at least one tumor feature (false discovery rate < 0.05). Five loci showed associations (P < 0.05) in opposite directions between luminal and non-luminal subtypes. In silico analyses showed that these five loci contained cell-specific enhancers that differed between normal luminal and basal mammary cells. The genetic correlations between five intrinsic-like subtypes ranged from 0.35 to 0.80. The proportion of genome-wide chip heritability explained by all known susceptibility loci was 54.2% for luminal A-like disease and 37.6% for triple-negative disease. The odds ratios of polygenic risk scores, which included 330 variants, for the highest 1% of quantiles compared with middle quantiles were 5.63 and 3.02 for luminal A-like and triple-negative disease, respectively. These findings provide an improved understanding of genetic predisposition to breast cancer subtypes and will inform the development of subtype-specific polygenic risk scores.
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- $a Dörk, Thilo $u Gynaecology Research Unit, Hannover Medical School, Hannover, Germany.
- 700 1_
- $a Dwek, Miriam $u Department of Biomedical Sciences, Faculty of Science and Technology, University of Westminster, London, UK.
- 700 1_
- $a Eccles, Diana M $u Cancer Sciences Academic Unit, Faculty of Medicine, University of Southampton, Southampton, UK.
- 700 1_
- $a Ekici, Arif B $u Institute of Human Genetics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center ER-EMN, Erlangen, Germany.
- 700 1_
- $a Evans, D Gareth $u Manchester Centre for Genomic Medicine, St Mary's Hospital, Manchester NIHR Biomedical Research Centre, Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK. Division of Evolution and Genomic Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.
- 700 1_
- $a Fasching, Peter A $u Department of Gynecology and Obstetrics, Comprehensive Cancer Center ER-EMN, University Hospital Erlangen, Friedrich-Alexander University of Erlangen-Nuremberg, Erlangen, Germany. David Geffen School of Medicine, Department of Medicine, Division of Hematology and Oncology, University of California, Los Angeles, Los Angeles, CA, USA.
- 700 1_
- $a Figueroa, Jonine $u Usher Institute of Population Health Sciences and Informatics, University of Edinburgh Medical School, Edinburgh, UK.
- 700 1_
- $a Foretova, Lenka $u Department of Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute, Brno, Czech Republic.
- 700 1_
- $a Fostira, Florentia $u Molecular Diagnostics Laboratory, INRASTES, National Centre for Scientific Research 'Demokritos', Athens, Greece.
- 700 1_
- $a Friedman, Eitan $u The Susanne Levy Gertner Oncogenetics Unit, Chaim Sheba Medical Center, Ramat Gan, Israel.
- 700 1_
- $a Frost, Debra $u Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, UK.
- 700 1_
- $a Gago-Dominguez, Manuela $u Genomic Medicine Group, Galician Foundation of Genomic Medicine, IDIS, Complejo Hospitalario Universitario de Santiago, SERGAS, Santiago de Compostela, Spain. Moores Cancer Center, University of California, San Diego, La Jolla, CA, USA.
- 700 1_
- $a Gapstur, Susan M $u Behavioral and Epidemiology Research Group, American Cancer Society, Atlanta, GA, USA.
- 700 1_
- $a Garber, Judy $u Cancer Risk and Prevention Clinic, Dana-Farber Cancer Institute, Boston, MA, USA.
- 700 1_
- $a García-Sáenz, José A $u Medical Oncology Department, Hospital Clínico San Carlos, Instituto de Investigación Sanitaria San Carlos (IdISSC), Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, Spain.
- 700 1_
- $a Gaudet, Mia M $u Behavioral and Epidemiology Research Group, American Cancer Society, Atlanta, GA, USA.
- 700 1_
- $a Gayther, Simon A $u Center for Bioinformatics and Functional Genomics and the Cedars-Sinai Genomics Core, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
- 700 1_
- $a Giles, Graham G $u Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, Victoria, Australia. Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Victoria, Australia. Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Melbourne, Victoria, Australia.
- 700 1_
- $a Godwin, Andrew K $u Department of Pathology and Laboratory Medicine, Kansas University Medical Center, Kansas City, KS, USA.
- 700 1_
- $a Goldberg, Mark S $u Department of Medicine, McGill University, Montréal, Québec, Canada. Division of Clinical Epidemiology, Royal Victoria Hospital, McGill University, Montréal, Québec, Canada. Breast Cancer Research Unit, Cancer Research Institute, University Malaya Medical Centre, Kuala Lumpur, Malaysia.
- 700 1_
- $a Goldgar, David E $u Department of Dermatology, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT, USA.
- 700 1_
- $a González-Neira, Anna $u Human Cancer Genetics Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.
- 700 1_
- $a Greene, Mark H $u Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
- 700 1_
- $a Gronwald, Jacek $u Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.
- 700 1_
- $a Guénel, Pascal $u Cancer and Environment Group, Center for Research in Epidemiology and Population Health (CESP), INSERM, University Paris-Sud, University of Paris-Saclay, Paris, France.
- 700 1_
- $a Häberle, Lothar $u Department of Gynaecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center ER-EMN, Erlangen, Germany.
- 700 1_
- $a Hahnen, Eric $u Center for Familial Breast and Ovarian Cancer, Center for Integrated Oncology (CIO), Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
- 700 1_
- $a Haiman, Christopher A $u Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
- 700 1_
- $a Hake, Christopher R $u Waukesha Memorial Hospital Pro Health Care, Waukesha, WI, USA.
- 700 1_
- $a Hall, Per $u Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. Department of Oncology, Södersjukhuset, Stockholm, Sweden.
- 700 1_
- $a Hamann, Ute $u Molecular Genetics of Breast Cancer, DKFZ, Heidelberg, Germany.
- 700 1_
- $a Harkness, Elaine F $u Division of Informatics, Imaging and Data Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK. Nightingale Breast Screening Centre, Wythenshawe Hospital, Manchester University NHS Foundation Trust, Manchester, UK.
- 700 1_
- $a Heemskerk-Gerritsen, Bernadette A M $u Department of Medical Oncology, Family Cancer Clinic, Erasmus MC Cancer Institute, Rotterdam, the Netherlands.
- 700 1_
- $a Hillemanns, Peter $u Gynaecology Research Unit, Hannover Medical School, Hannover, Germany.
- 700 1_
- $a Hogervorst, Frans B L $u Family Cancer Clinic, The Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Amsterdam, the Netherlands.
- 700 1_
- $a Holleczek, Bernd $u Saarland Cancer Registry, Saarbrücken, Germany.
- 700 1_
- $a Hollestelle, Antoinette $u Department of Medical Oncology, Family Cancer Clinic, Erasmus MC Cancer Institute, Rotterdam, the Netherlands.
- 700 1_
- $a Hooning, Maartje J $u Department of Medical Oncology, Family Cancer Clinic, Erasmus MC Cancer Institute, Rotterdam, the Netherlands.
- 700 1_
- $a Hoover, Robert N $u Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health (NIH), Department of Health and Human Services, Bethesda, MD, USA.
- 700 1_
- $a Hopper, John L $u Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Victoria, Australia.
- 700 1_
- $a Howell, Anthony $u Division of Cancer Sciences, University of Manchester, Manchester, UK.
- 700 1_
- $a Huebner, Hanna $u Department of Gynecology and Obstetrics, Comprehensive Cancer Center ER-EMN, University Hospital Erlangen, Friedrich-Alexander University of Erlangen-Nuremberg, Erlangen, Germany.
- 700 1_
- $a Hulick, Peter J $u Center for Medical Genetics, NorthShore University HealthSystem, Evanston, IL, USA.
- 700 1_
- $a Imyanitov, Evgeny N $u N.N. Petrov Institute of Oncology, St. Petersburg, Russia.
- 700 1_
- $a Isaacs, Claudine $u Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA.
- 700 1_
- $a Izatt, Louise $u Clinical Genetics, Guy's and St. Thomas' NHS Foundation Trust, London, UK.
- 700 1_
- $a Jager, Agnes $u Department of Medical Oncology, Family Cancer Clinic, Erasmus MC Cancer Institute, Rotterdam, the Netherlands.
- 700 1_
- $a Jakimovska, Milena $u Research Centre for Genetic Engineering and Biotechnology 'Georgi D. Efremov', Macedonian Academy of Sciences and Arts, Skopje, Republic of Macedonia.
- 700 1_
- $a Jakubowska, Anna $u Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland. Independent Laboratory of Molecular Biology and Genetic Diagnostics, Pomeranian Medical University, Szczecin, Poland.
- 700 1_
- $a James, Paul $u Parkville Familial Cancer Centre, Peter MacCallum Cancer Center, Melbourne, Victoria, Australia.
- 700 1_
- $a Janavicius, Ramunas $u Hematology, Oncology and Transfusion Medicine Center, Department of Molecular and Regenerative Medicine, Vilnius University Hospital Santariskiu Clinics, Vilnius, Lithuania. State Research Institute Center for Innovative Medicine, Vilnius, Lithuania.
- 700 1_
- $a Janni, Wolfgang $u Department of Gynaecology and Obstetrics, University Hospital Ulm, Ulm, Germany.
- 700 1_
- $a John, Esther M $u Department of Medicine, Division of Oncology, Stanford Cancer Institute, School of Medicine, Stanford University, Stanford, CA, USA.
- 700 1_
- $a Jones, Michael E $u Division of Genetics and Epidemiology, The Institute of Cancer Research, London, UK.
- 700 1_
- $a Jung, Audrey $u Division of Cancer Epidemiology, DKFZ, Heidelberg, Germany.
- 700 1_
- $a Kaaks, Rudolf $u Division of Cancer Epidemiology, DKFZ, Heidelberg, Germany.
- 700 1_
- $a Kapoor, Pooja Middha $u Division of Cancer Epidemiology, DKFZ, Heidelberg, Germany. Faculty of Medicine, University of Heidelberg, Heidelberg, Germany.
- 700 1_
- $a Karlan, Beth Y $u David Geffen School of Medicine, Department of Obstetrics and Gynecology, University of California, Los Angeles, Los Angeles, CA, USA.
- 700 1_
- $a Keeman, Renske $u Division of Molecular Pathology, The Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Amsterdam, the Netherlands.
- 700 1_
- $a Khan, Sofia $u Department of Obstetrics and Gynecology, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.
- 700 1_
- $a Khusnutdinova, Elza $u Institute of Biochemistry and Genetics, Ufa Federal Research Centre of the Russian Academy of Sciences, Ufa, Russia. Department of Genetics and Fundamental Medicine, Bashkir State Medical University, Ufa, Russia.
- 700 1_
- $a Kitahara, Cari M $u Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
- 700 1_
- $a Ko, Yon-Dschun $u Department of Internal Medicine, Evangelische Kliniken Bonn, Johanniter Krankenhaus, Bonn, Germany.
- 700 1_
- $a Konstantopoulou, Irene $u Molecular Diagnostics Laboratory, INRASTES, National Centre for Scientific Research 'Demokritos', Athens, Greece.
- 700 1_
- $a Koppert, Linetta B $u Department of Surgical Oncology, Family Cancer Clinic, Erasmus MC Cancer Institute, Rotterdam, the Netherlands.
- 700 1_
- $a Koutros, Stella $u Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health (NIH), Department of Health and Human Services, Bethesda, MD, USA.
- 700 1_
- $a Kristensen, Vessela N $u Department of Cancer Genetics, Institute for Cancer Research, Oslo University Hospital-Radiumhospitalet, Oslo, Norway. Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.
- 700 1_
- $a Laenkholm, Anne-Vibeke $u Department of Surgical Pathology, Zealand University Hospital, Slagelse, Denmark.
- 700 1_
- $a Lambrechts, Diether $u VIB Center for Cancer Biology, VIB, Leuven, Belgium. Laboratory of Translational Genetics, Department of Human Genetics, University of Leuven, Leuven, Belgium.
- 700 1_
- $a Larsson, Susanna C $u Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden. Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.
- 700 1_
- $a Laurent-Puig, Pierre $u Université Paris Sorbonne Cité, INSERM UMR-S1147, Paris, France.
- 700 1_
- $a Lazaro, Conxi $u Molecular Diagnostic Unit, Hereditary Cancer Program, Bellvitge Biomedical Research Institute (IDIBELL), Catalan Institute of Oncology (ICO), CIBERONC, Barcelona, Spain.
- 700 1_
- $a Lazarova, Emilija $u Ss. Cyril and Methodius University in Skopje, Medical Faculty, University Clinic of Radiotherapy and Oncology, Skopje, Republic of North Macedonia.
- 700 1_
- $a Lejbkowicz, Flavio $u Clalit National Cancer Control Center, Carmel Medical Center and Technion Faculty of Medicine, Haifa, Israel.
- 700 1_
- $a Leslie, Goska $u Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
- 700 1_
- $a Lesueur, Fabienne $u Genetic Epidemiology of Cancer Team, INSERM U900, Paris, France.
- 700 1_
- $a Lindblom, Annika $u Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden. Department of Clinical Genetics, Karolinska University Hospital, Stockholm, Sweden.
- 700 1_
- $a Lissowska, Jolanta $u Department of Cancer Epidemiology and Prevention, M. Sklodowska-Curie Cancer Center, Oncology Institute, Warsaw, Poland.
- 700 1_
- $a Lo, Wing-Yee $u Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany. University of Tübingen, Tübingen, Germany.
- 700 1_
- $a Loud, Jennifer T $u Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
- 700 1_
- $a Lubinski, Jan $u Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.
- 700 1_
- $a Lukomska, Alicja $u Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.
- 700 1_
- $a MacInnis, Robert J $u Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, Victoria, Australia. Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Victoria, Australia.
- 700 1_
- $a Mannermaa, Arto $u Translational Cancer Research Area, University of Eastern Finland, Kuopio, Finland. Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Kuopio, Finland. Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, Kuopio, Finland.
- 700 1_
- $a Manoochehri, Mehdi $u Molecular Genetics of Breast Cancer, DKFZ, Heidelberg, Germany.
- 700 1_
- $a Manoukian, Siranoush $u Unit of Medical Genetics, Department of Medical Oncology and Hematology, Fondazione IRCCS Istituto Nazionale dei Tumori (INT), Milan, Italy.
- 700 1_
- $a Margolin, Sara $u Department of Oncology, Södersjukhuset, Stockholm, Sweden. Department of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, Stockholm, Sweden.
- 700 1_
- $a Martinez, Maria Elena $u Moores Cancer Center, University of California, San Diego, La Jolla, CA, USA. Department of Family Medicine and Public Health, University of California, San Diego, La Jolla, CA, USA.
- 700 1_
- $a Matricardi, Laura $u Immunology and Molecular Oncology Unit, Veneto Institute of Oncology (IOV)-IRCCS, Padua, Italy.
- 700 1_
- $a McGuffog, Lesley $u Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
- 700 1_
- $a McLean, Catriona $u Department of Anatomical Pathology, The Alfred Hospital, Melbourne, Victoria, Australia.
- 700 1_
- $a Mebirouk, Noura $u Genetic Epidemiology of Cancer Team, INSERM U900, Institut Curie, PSL University, Mines ParisTech, Paris, France.
- 700 1_
- $a Meindl, Alfons $u Department of Gynecology and Obstetrics, Ludwig Maximilian University of Munich, Munich, Germany.
- 700 1_
- $a Menon, Usha $u MRC Clinical Trials Unit at UCL, Institute of Clinical Trials and Methodology, University College London, London, UK.
- 700 1_
- $a Miller, Austin $u NRG Oncology, Statistics and Data Management Center, Roswell Park Cancer Institute, Buffalo, NY, USA.
- 700 1_
- $a Mingazheva, Elvira $u Department of Genetics and Fundamental Medicine, Bashkir State Medical University, Ufa, Russia.
- 700 1_
- $a Montagna, Marco $u Immunology and Molecular Oncology Unit, Veneto Institute of Oncology (IOV)-IRCCS, Padua, Italy.
- 700 1_
- $a Mulligan, Anna Marie $u Laboratory Medicine Program, University Health Network, Toronto, Ontario, Canada. Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.
- 700 1_
- $a Mulot, Claire $u Université Paris Sorbonne Cité, INSERM UMR-S1147, Paris, France.
- 700 1_
- $a Muranen, Taru A $u Department of Obstetrics and Gynecology, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.
- 700 1_
- $a Nathanson, Katherine L $u Department of Medicine, Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
- 700 1_
- $a Neuhausen, Susan L $u Department of Population Sciences, Beckman Research Institute of City of Hope, Duarte, CA, USA.
- 700 1_
- $a Nevanlinna, Heli $u Department of Obstetrics and Gynecology, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.
- 700 1_
- $a Neven, Patrick $u Leuven Multidisciplinary Breast Center, Department of Oncology, Leuven Cancer Institute, University Hospitals Leuven, Leuven, Belgium.
- 700 1_
- $a Newman, William G $u Manchester Centre for Genomic Medicine, St Mary's Hospital, Manchester NIHR Biomedical Research Centre, Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK. Division of Evolution and Genomic Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.
- 700 1_
- $a Nielsen, Finn C $u Center for Genomic Medicine, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
- 700 1_
- $a Nikitina-Zake, Liene $u Latvian Biomedical Research and Study Centre, Riga, Latvia.
- 700 1_
- $a Nodora, Jesse $u Moores Cancer Center, University of California, San Diego, La Jolla, CA, USA. Department of Family Medicine and Public Health, School of Medicine, University of California, San Diego, La Jolla, CA, USA.
- 700 1_
- $a Offit, Kenneth $u Clinical Genetics Research Laboratory, Department of Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
- 700 1_
- $a Olah, Edith $u Department of Molecular Genetics, National Institute of Oncology, Budapest, Hungary.
- 700 1_
- $a Olopade, Olufunmilayo I $u Center for Clinical Cancer Genetics, The University of Chicago, Chicago, IL, USA. Department of Clinical Pathology, University of Melbourne, Melbourne, Victoria, Australia.
- 700 1_
- $a Olsson, Håkan $u Department of Cancer Epidemiology, Clinical Sciences, Lund University, Lund, Sweden. Clinical Genetics Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
- 700 1_
- $a Orr, Nick $u Centre for Cancer Research and Cell Biology, Queen's University Belfast, Belfast, Northern Ireland, UK.
- 700 1_
- $a Papi, Laura $u Unit of Medical Genetics, Department of Biomedical, Experimental and Clinical Sciences, University of Florence, Florence, Italy.
- 700 1_
- $a Papp, Janos $u Department of Molecular Genetics, National Institute of Oncology, Budapest, Hungary.
- 700 1_
- $a Park-Simon, Tjoung-Won $u Gynaecology Research Unit, Hannover Medical School, Hannover, Germany.
- 700 1_
- $a Parsons, Michael T $u Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
- 700 1_
- $a Peissel, Bernard $u Unit of Medical Genetics, Department of Medical Oncology and Hematology, Fondazione IRCCS Istituto Nazionale dei Tumori (INT), Milan, Italy.
- 700 1_
- $a Peixoto, Ana $u Department of Genetics, Portuguese Oncology Institute, Porto, Portugal.
- 700 1_
- $a Peshkin, Beth $u Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA.
- 700 1_
- $a Peterlongo, Paolo $u Genome Diagnostics Program, IFOM, FIRC Institute of Molecular Oncology, Milan, Italy.
- 700 1_
- $a Peto, Julian $u Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK. Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK.
- 700 1_
- $a Phillips, Kelly-Anne $u Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Victoria, Australia. Peter MacCallum Cancer Center, Melbourne, Victoria, Australia. Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia.
- 700 1_
- $a Piedmonte, Marion $u NRG Oncology, Statistics and Data Management Center, Roswell Park Cancer Institute, Buffalo, NY, USA.
- 700 1_
- $a Plaseska-Karanfilska, Dijana $u Research Centre for Genetic Engineering and Biotechnology 'Georgi D. Efremov', Macedonian Academy of Sciences and Arts, Skopje, Republic of Macedonia.
- 700 1_
- $a Prajzendanc, Karolina $u Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.
- 700 1_
- $a Prentice, Ross $u Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
- 700 1_
- $a Prokofyeva, Darya $u Department of Genetics and Fundamental Medicine, Bashkir State Medical University, Ufa, Russia.
- 700 1_
- $a Rack, Brigitte $u Department of Gynaecology and Obstetrics, University Hospital Ulm, Ulm, Germany.
- 700 1_
- $a Radice, Paolo $u Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Research, INT, Milan, Italy.
- 700 1_
- $a Ramus, Susan J $u Adult Cancer Program, Lowy Cancer Research Centre, University of NSW Sydney, Sydney, New South Wales, Australia. School of Women's and Children's Health, Faculty of Medicine, University of NSW Sydney, Sydney, New South Wales, Australia. The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Sydney, New South Wales, Australia.
- 700 1_
- $a Rantala, Johanna $u Clinical Genetics, Karolinska Institutet, Stockholm, Sweden.
- 700 1_
- $a Rashid, Muhammad U $u Molecular Genetics of Breast Cancer, DKFZ, Heidelberg, Germany. Department of Basic Sciences, Shaukat Khanum Memorial Cancer Hospital and Research Centre (SKMCH&RC), Lahore, Pakistan.
- 700 1_
- $a Rennert, Gad $u Clalit National Cancer Control Center, Carmel Medical Center and Technion Faculty of Medicine, Haifa, Israel.
- 700 1_
- $a Rennert, Hedy S $u Clalit National Cancer Control Center, Carmel Medical Center and Technion Faculty of Medicine, Haifa, Israel.
- 700 1_
- $a Risch, Harvey A $u Chronic Disease Epidemiology, Yale School of Public Health, New Haven, CT, USA.
- 700 1_
- $a Romero, Atocha $u Medical Oncology Department, Hospital Universitario Puerta de Hierro, Madrid, Spain. Biomedical Sciences Institute (ICBAS), University of Porto, Porto, Portugal.
- 700 1_
- $a Rookus, Matti A $u Department of Epidemiology, The Netherlands Cancer Institute, Amsterdam, the Netherlands.
- 700 1_
- $a Rübner, Matthias $u Department of Gynaecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center ER-EMN, Erlangen, Germany.
- 700 1_
- $a Rüdiger, Thomas $u Institute of Pathology, Staedtisches Klinikum Karlsruhe, Karlsruhe, Germany.
- 700 1_
- $a Saloustros, Emmanouil $u Department of Oncology, University Hospital of Larissa, Larissa, Greece.
- 700 1_
- $a Sampson, Sarah $u Prevent Breast Cancer Centre and Nightingale Breast Screening Centre, Manchester University NHS Foundation Trust, Manchester, UK.
- 700 1_
- $a Sandler, Dale P $u Epidemiology Branch, National Institute of Environmental Health Sciences, NIH, Durham, NC, USA.
- 700 1_
- $a Sawyer, Elinor J $u Research Oncology, Guy's Hospital, King's College London, London, UK.
- 700 1_
- $a Scheuner, Maren T $u Cancer Genetics and Prevention Program, University of California, San Francisco, San Francisco, CA, USA.
- 700 1_
- $a Schmutzler, Rita K $u Center for Familial Breast and Ovarian Cancer, Center for Integrated Oncology (CIO), Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
- 700 1_
- $a Schneeweiss, Andreas $u Molecular Biology of Breast Cancer, University Women's Clinic Heidelberg, University of Heidelberg, Heidelberg, Germany. NCT, University Hospital and DKFZ, Heidelberg, Germany.
- 700 1_
- $a Schoemaker, Minouk J $u Division of Genetics and Epidemiology, The Institute of Cancer Research, London, UK.
- 700 1_
- $a Schöttker, Ben $u Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.
- 700 1_
- $a Schürmann, Peter $u Gynaecology Research Unit, Hannover Medical School, Hannover, Germany.
- 700 1_
- $a Senter, Leigha $u Clinical Cancer Genetics Program, Division of Human Genetics, Department of Internal Medicine, Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA.
- 700 1_
- $a Sharma, Priyanka $u Department of Internal Medicine, Division of Oncology, University of Kansas Medical Center, Westwood, Kansas City, KS, USA.
- 700 1_
- $a Sherman, Mark E $u Department of Health Sciences Research, Mayo Clinic College of Medicine, Jacksonville, FL, USA.
- 700 1_
- $a Shu, Xiao-Ou $u Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA.
- 700 1_
- $a Singer, Christian F $u Department of Obstetrics and Gynecology and Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria.
- 700 1_
- $a Smichkoska, Snezhana $u Ss. Cyril and Methodius University in Skopje, Medical Faculty, University Clinic of Radiotherapy and Oncology, Skopje, Republic of North Macedonia.
- 700 1_
- $a Soucy, Penny $u Genomics Center, Centre Hospitalier Universitaire de Québec-Université Laval Research Center, Québec City, Québec, Canada.
- 700 1_
- $a Southey, Melissa C $u Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Melbourne, Victoria, Australia.
- 700 1_
- $a Spinelli, John J $u Population Oncology, BC Cancer, Vancouver, British Columbia, Canada. School of Population and Public Health, University of British Columbia, Vancouver, British Columbia, Canada.
- 700 1_
- $a Stone, Jennifer $u Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Victoria, Australia. Curtin UWA Centre for Genetic Origins of Health and Disease, Curtin University and University of Western Australia, Perth, Western Australia, Australia.
- 700 1_
- $a Stoppa-Lyonnet, Dominique $u Department of Genetics, INSERM U830, Institut Curie, Paris Descartes Sorbonne-Paris Cité University, Paris, France.
- 700 1_
- $a Swerdlow, Anthony J $u Division of Genetics and Epidemiology, The Institute of Cancer Research, London, UK. Division of Breast Cancer Research, The Institute of Cancer Research, London, UK.
- 700 1_
- $a Szabo, Csilla I $u National Human Genome Research Institute, National Cancer Institute, Bethesda, MD, USA.
- 700 1_
- $a Tamimi, Rulla M $u Program in Genetic Epidemiology and Statistical Genetics, Harvard T.H. Chan School of Public Health, Boston, MA, USA. Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
- 700 1_
- $a Tapper, William J $u Faculty of Medicine, University of Southampton, Southampton, UK.
- 700 1_
- $a Taylor, Jack A $u Epidemiology Branch, National Institute of Environmental Health Sciences, NIH, Durham, NC, USA. Epigenetic and Stem Cell Biology Laboratory, National Institute of Environmental Health Sciences, NIH, Durham, NC, USA.
- 700 1_
- $a Teixeira, Manuel R $u Department of Genetics, Portuguese Oncology Institute, Porto, Portugal. Biomedical Sciences Institute (ICBAS), University of Porto, Porto, Portugal.
- 700 1_
- $a Terry, MaryBeth $u Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA.
- 700 1_
- $a Thomassen, Mads $u Department of Clinical Genetics, Odense University Hospital, Odense, Denmark.
- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
- $a van Veen, Elke M $u Manchester Centre for Genomic Medicine, St Mary's Hospital, Manchester NIHR Biomedical Research Centre, Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK. Division of Evolution and Genomic Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.
- 700 1_
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- 700 1_
- $a Vega, Ana $u Molecular Medicine Unit, Fundación Pública Galega de Medicina Xenómica, Santiago de Compostela, Spain. Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), Complejo Hospitalario Universitario de Santiago, Servicio Galego de Saude (SERGAS), Santiago de Compostela, Spain. CIBERER, Santiago de Compostela, Spain.
- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
- $a Wildiers, Hans $u Leuven Multidisciplinary Breast Center, Department of Oncology, Leuven Cancer Institute, University Hospitals Leuven, Leuven, Belgium.
- 700 1_
- $a Winqvist, Robert $u Laboratory of Cancer Genetics and Tumor Biology, Cancer and Translational Medicine Research Unit, Biocenter Oulu, University of Oulu, Oulu, Finland. Laboratory of Cancer Genetics and Tumor Biology, Northern Finland Laboratory Centre Oulu, Oulu, Finland. Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada. Department of Human Genetics, Leiden University Medical Center, Leiden, the Netherlands.
- 700 1_
- $a Wolk, Alicja $u Independent Laboratory of Molecular Biology and Genetic Diagnostics, Pomeranian Medical University, Szczecin, Poland. Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden. Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.
- 700 1_
- $a Yang, Xiaohong R $u Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health (NIH), Department of Health and Human Services, Bethesda, MD, USA.
- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
- $a Milne, Roger L $u Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, Victoria, Australia. Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Victoria, Australia. Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Melbourne, Victoria, Australia.
- 700 1_
- $a Kraft, Peter $u Program in Genetic Epidemiology and Statistical Genetics, Harvard T.H. Chan School of Public Health, Boston, MA, USA. Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
- $a Antoniou, Antonis C $u Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
- 700 1_
- $a Schmidt, Marjanka K $u Division of Molecular Pathology, The Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Amsterdam, the Netherlands. Division of Psychosocial Research and Epidemiology, The Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Amsterdam, the Netherlands.
- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 710 2_
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