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Cumulative Burden of Colorectal Cancer-Associated Genetic Variants Is More Strongly Associated With Early-Onset vs Late-Onset Cancer
AN. Archambault, YR. Su, J. Jeon, M. Thomas, Y. Lin, DV. Conti, AK. Win, LC. Sakoda, I. Lansdorp-Vogelaar, EFP. Peterse, AG. Zauber, D. Duggan, AN. Holowatyj, JR. Huyghe, H. Brenner, M. Cotterchio, S. Bézieau, SL. Schmit, CK. Edlund, MC. Southey,...
Language English Country United States
Document type Journal Article, Multicenter Study, Observational Study, Research Support, N.I.H., Extramural, Research Support, N.I.H., Intramural, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.
Grant support
R01 CA067941
NCI NIH HHS - United States
U01 HG004446
NHGRI NIH HHS - United States
K05 CA154337
NCI NIH HHS - United States
S10 OD020069
NIH HHS - United States
U01 CA067941
NCI NIH HHS - United States
HHSN268201100001I
NHLBI NIH HHS - United States
R01 CA197350
NCI NIH HHS - United States
R01 CA076366
NCI NIH HHS - United States
R35 CA197735
NCI NIH HHS - United States
RC2 AG036607
NIA NIH HHS - United States
T32 HS026120
AHRQ HHS - United States
U01 HG004438
NHGRI NIH HHS - United States
U01 CA074799
NCI NIH HHS - United States
U10 CA037429
NCI NIH HHS - United States
U01 CA182883
NCI NIH HHS - United States
P01 CA087969
NCI NIH HHS - United States
HHSN261201000035C
NCI NIH HHS - United States
HHSN261201000006C
NCI NIH HHS - United States
P30 CA015704
NCI NIH HHS - United States
HHSN268201100004I
NHLBI NIH HHS - United States
U24 CA074783
NCI NIH HHS - United States
R01 CA206279
NCI NIH HHS - United States
P01 CA055075
NCI NIH HHS - United States
N01 CN067009
NCI NIH HHS - United States
R01 CA151993
NCI NIH HHS - United States
HHSN268201100046C
NHLBI NIH HHS - United States
P30 DK034987
NIDDK NIH HHS - United States
R01 CA048998
NCI NIH HHS - United States
UM1 CA182934
NCI NIH HHS - United States
R01 CA189184
NCI NIH HHS - United States
U01 CA167552
NCI NIH HHS - United States
HHSN268201100003C
WHI NIH HHS - United States
Z01 CP010200
Intramural NIH HHS - United States
U24 CA074794
NCI NIH HHS - United States
U01 CA164930
NCI NIH HHS - United States
N01PC35137
NCI NIH HHS - United States
R01 CA066635
NCI NIH HHS - United States
U24 CA074806
NCI NIH HHS - United States
U01 CA206110
NCI NIH HHS - United States
R01 CA137178
NCI NIH HHS - United States
U24 CA097735
NCI NIH HHS - United States
U01 CA074794
NCI NIH HHS - United States
P30 CA008748
NCI NIH HHS - United States
U01 CA167551
NCI NIH HHS - United States
HHSN261201300011C
CCR NIH HHS - United States
HHSN261201300012I
NCI NIH HHS - United States
P30 CA076292
NCI NIH HHS - United States
P30 CA014089
NCI NIH HHS - United States
R01 CA081488
NCI NIH HHS - United States
N01PC35142
NCI NIH HHS - United States
HHSN271201100004C
NIA NIH HHS - United States
R01 CA201407
NCI NIH HHS - United States
R01 CA063464
NCI NIH HHS - United States
P01 CA033619
NCI NIH HHS - United States
P20 CA233216
NCI NIH HHS - United States
UM1 CA186107
NCI NIH HHS - United States
HHSN268201100002C
WHI NIH HHS - United States
R01 CA207371
NCI NIH HHS - United States
HHSN261201300021C
NCI NIH HHS - United States
HHSN261201000035I
NCI NIH HHS - United States
R01 CA042182
NCI NIH HHS - United States
U01 CA063464
NCI NIH HHS - United States
R01 CA060987
NCI NIH HHS - United States
U01 CA097735
NCI NIH HHS - United States
T32 ES013678
NIEHS NIH HHS - United States
R01 CA136726
NCI NIH HHS - United States
P30 CA016058
NCI NIH HHS - United States
R03 CA215775
NCI NIH HHS - United States
UM1 CA167552
NCI NIH HHS - United States
N01RC37004
CCR NIH HHS - United States
U01 CA122839
NCI NIH HHS - United States
HHSN268201100002I
NHLBI NIH HHS - United States
U01 CA074783
NCI NIH HHS - United States
N01 CN045165
NCI NIH HHS - United States
U24 CA074799
NCI NIH HHS - United States
P01 CA196569
NCI NIH HHS - United States
U01 CA074806
NCI NIH HHS - United States
U24 CA074800
NCI NIH HHS - United States
P50 CA127003
NCI NIH HHS - United States
UM1 CA182883
NCI NIH HHS - United States
K07 CA190673
NCI NIH HHS - United States
P30 CA071789
NCI NIH HHS - United States
HHSN261201000121C
NCI NIH HHS - United States
MR/L01629X/1
Medical Research Council - United Kingdom
R37 CA054281
NCI NIH HHS - United States
U01 CA074800
NCI NIH HHS - United States
HHSN268201100001C
WHI NIH HHS - United States
HHSN268201100004C
WHI NIH HHS - United States
P30 CA042014
NCI NIH HHS - United States
U19 CA148107
NCI NIH HHS - United States
10124
Cancer Research UK - United Kingdom
NV15-27580A
MZ0
CEP Register
- MeSH
- Medical History Taking MeSH
- Genome-Wide Association Study MeSH
- Datasets as Topic MeSH
- Genetic Predisposition to Disease * MeSH
- Genotyping Techniques MeSH
- Polymorphism, Single Nucleotide MeSH
- Cohort Studies MeSH
- Colorectal Neoplasms genetics MeSH
- Middle Aged MeSH
- Humans MeSH
- DNA Mutational Analysis MeSH
- Mutation Rate MeSH
- Risk Factors MeSH
- Whole Genome Sequencing MeSH
- Case-Control Studies MeSH
- Age of Onset MeSH
- Life Style MeSH
- Check Tag
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Multicenter Study MeSH
- Observational Study MeSH
- Research Support, Non-U.S. Gov't MeSH
- Research Support, N.I.H., Extramural MeSH
- Research Support, N.I.H., Intramural MeSH
- Research Support, U.S. Gov't, P.H.S. MeSH
BACKGROUND & AIMS: Early-onset colorectal cancer (CRC, in persons younger than 50 years old) is increasing in incidence; yet, in the absence of a family history of CRC, this population lacks harmonized recommendations for prevention. We aimed to determine whether a polygenic risk score (PRS) developed from 95 CRC-associated common genetic risk variants was associated with risk for early-onset CRC. METHODS: We studied risk for CRC associated with a weighted PRS in 12,197 participants younger than 50 years old vs 95,865 participants 50 years or older. PRS was calculated based on single nucleotide polymorphisms associated with CRC in a large-scale genome-wide association study as of January 2019. Participants were pooled from 3 large consortia that provided clinical and genotyping data: the Colon Cancer Family Registry, the Colorectal Transdisciplinary Study, and the Genetics and Epidemiology of Colorectal Cancer Consortium and were all of genetically defined European descent. Findings were replicated in an independent cohort of 72,573 participants. RESULTS: Overall associations with CRC per standard deviation of PRS were significant for early-onset cancer, and were stronger compared with late-onset cancer (P for interaction = .01); when we compared the highest PRS quartile with the lowest, risk increased 3.7-fold for early-onset CRC (95% CI 3.28-4.24) vs 2.9-fold for late-onset CRC (95% CI 2.80-3.04). This association was strongest for participants without a first-degree family history of CRC (P for interaction = 5.61 × 10-5). When we compared the highest with the lowest quartiles in this group, risk increased 4.3-fold for early-onset CRC (95% CI 3.61-5.01) vs 2.9-fold for late-onset CRC (95% CI 2.70-3.00). Sensitivity analyses were consistent with these findings. CONCLUSIONS: In an analysis of associations with CRC per standard deviation of PRS, we found the cumulative burden of CRC-associated common genetic variants to associate with early-onset cancer, and to be more strongly associated with early-onset than late-onset cancer, particularly in the absence of CRC family history. Analyses of PRS, along with environmental and lifestyle risk factors, might identify younger individuals who would benefit from preventive measures.
Behavioral and Epidemiology Research Group American Cancer Society Atlanta Georgia
Biomedicine Institute University of León León Spain
Broad Institute of Harvard and MIT Cambridge Massachusetts
Cancer Epidemiology and Intelligence Division Cancer Council Victoria Melbourne Victoria Australia
Center for Public Health Genomics University of Virginia Charlottesville Virginia
CIBER in Epidemiology and Public Health Madrid Spain
Clalit National Cancer Control Center Haifa Israel
Department of Biostatistics University of Washington Seattle Washington
Department of Cancer Epidemiology H Lee Moffitt Cancer Center and Research Institute Tampa Florida
Department of Clinical Genetics Karolinska University Hospital Stockholm Sweden
Department of Clinical Sciences Faculty of Medicine University of Barcelona Barcelona Spain
Department of Community Medicine and Epidemiology Lady Davis Carmel Medical Center Haifa Israel
Department of Epidemiology Geisel School of Medicine at Dartmouth Lebanon New Hampshire
Department of Epidemiology Johns Hopkins Bloomberg School of Public Health Baltimore Maryland
Department of Epidemiology Regional Health Council IMIB Arrixaca Murcia University Murcia Spain
Department of Epidemiology University of Michigan Ann Arbor Michigan
Department of Epidemiology University of Washington School of Public Health Seattle Washington
Department of Family Medicine University of Virginia Charlottesville Virginia
Department of Health Science Research Mayo Clinic Scottsdale Arizona
Department of Internal Medicine University of Utah Salt Lake City Utah
Department of Medicine 1 University Hospital Dresden Technische Universität Dresden Dresden Germany
Department of Medicine New York University School of Medicine New York New York
Department of Medicine University of North Carolina School of Medicine Chapel Hill North Carolina
Department of Medicine Weill Cornell Medical College New York New York
Department of Molecular Medicine and Surgery Karolinska Institutet Stockholm Sweden
Department of Public Health and Primary Care University of Cambridge Cambridge UK
Department of Public Health Erasmus MC University Medical Center Rotterdam The Netherlands
Department of Public Health Solutions National Institute for Health and Welfare Helsinki Finland
Department of Radiation Sciences Oncology Unit Umeå University Umeå Sweden
Division of Cancer Control and Population Sciences National Cancer Institute Bethesda Maryland
Division of Cancer Epidemiology German Cancer Research Center Heidelberg Germany
Division of Human Nutrition and Health Wageningen University and Research Wageningen The Netherlands
Division of Preventive Oncology German Cancer Research Center Heidelberg Germany
Division of Research Kaiser Permanente Northern California Oakland California
Epidemiology Program University of Hawaii Cancer Center Honolulu Hawaii
Escuela Andaluza de Salud Pública CIBER de Epidemiología y Salud Pública Granada Spain
Faculty of Medicine and Biomedical Center in Pilsen Charles University Pilsen Czech Republic
Genentech Inc Basel Switzerland
Genomic Medicine and Family Cancer Clinic The Royal Melbourne Hospital Parkville Victoria Australia
German Cancer Consortium Heidelberg Germany
Hellenic Health Foundation Athens Greece
Institute for Health Research Kaiser Permanente Colorado Aurora Colorado
Institute of Cancer Research Department of Medicine 1 Medical University of Vienna Vienna Austria
Institute of Environmental Medicine Karolinska Institute Stockholm Sweden
Leeds Institute of Cancer and Pathology University of Leeds Leeds UK
Medical Faculty University of Heidelberg Heidelberg Germany
Memorial University of Newfoundland Discipline of Genetics St John's Newfoundland Canada
Menzies Institute for Medical Research University of Tasmania Hobart Tasmania Australia
Moores Cancer Center University of California San Diego La Jolla California
Nuffield Department of Population Health University of Oxford Oxford UK
Ontario Institute for Cancer Research Toronto Ontario Canada
Population Health and Prevention Cancer Care Ontario Toronto Ontario Canada
Public Health Sciences Division Fred Hutchinson Cancer Research Center Seattle Washington
Radiotherapy Department Complejo Hospitalario Universitario de Vigo SERGAS Vigo Spain
Ruth and Bruce Rappaport Faculty of Medicine Technion Israel Institute of Technology Haifa Israel
School of Public Health Imperial College London London UK
School of Public Health University of Washington Seattle Washington
Section of Nutrition and Metabolism International Agency for Research on Cancer Lyon France
Service de Génétique Médicale Centre Hospitalier Universitaire Nantes Nantes France
SWOG Statistical Center Fred Hutchinson Cancer Research Center Seattle Washington
The Clinical Epidemiology Unit Memorial University Medical School St John's Newfoundland Canada
Translational Genomics Research Institute An Affiliate of City of Hope Phoenix Arizona
University Medical Centre Hamburg Eppendorf University Cancer Centre Hamburg Hamburg Germany
Wallenberg Centre for Molecular Medicine Umeå University Umeå Sweden
References provided by Crossref.org
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- 700 1_
- $a Castellví-Bel, Sergi $u Gastroenterology Department, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), University of Barcelona, Barcelona, Spain.
- 700 1_
- $a Moreira, Leticia $u Gastroenterology Department, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), University of Barcelona, Barcelona, Spain.
- 700 1_
- $a Vodicka, Pavel $u Department of Molecular Biology of Cancer, Institute of Experimental Medicine of the Czech Academy of Sciences, Prague, Czech Republic; Institute of Biology and Medical Genetics, First Faculty of Medicine, Charles University, Prague, Czech Republic; Faculty of Medicine and Biomedical Center in Pilsen, Charles University, Pilsen, Czech Republic.
- 700 1_
- $a Kampman, Ellen $u Division of Human Nutrition and Health, Wageningen University & Research, Wageningen, The Netherlands.
- 700 1_
- $a Giles, Graham G $u Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia; Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.
- 700 1_
- $a Albanes, Demetrius $u Department of Epidemiology, University of Washington School of Public Health, Seattle, Washington.
- 700 1_
- $a Baron, John A $u Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, North Carolina.
- 700 1_
- $a Berndt, Sonja I $u Department of Epidemiology, University of Washington School of Public Health, Seattle, Washington.
- 700 1_
- $a Brezina, Stefanie $u Institute of Cancer Research, Department of Medicine I, Medical University of Vienna, Vienna, Austria.
- 700 1_
- $a Buch, Stephan $u Huntsman Cancer Institute and Department of Population Health Sciences, University of Utah, Salt Lake City, Utah.
- 700 1_
- $a Buchanan, Daniel D $u Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia; Colorectal Oncogenomics Group, Department of Clinical Pathology, The University of Melbourne, Parkville, Victoria, Australia; Genomic Medicine and Family Cancer Clinic, The Royal Melbourne Hospital, Parkville, Victoria, Australia; University of Melbourne Centre for Cancer Research, Victorian Comprehensive Cancer Centre, Parkville, Victoria, Australia.
- 700 1_
- $a Trichopoulou, Antonia $u Hellenic Health Foundation, Athens, Greece.
- 700 1_
- $a Severi, Gianluca $u Centre de Recherche en Épidémiologie et Santé des Populations (CESP, Inserm U1018), Facultés de Médecine, Université Paris-Saclay, Gustave Roussy, Villejuif, France.
- 700 1_
- $a Chirlaque, María-Dolores $u CIBER in Epidemiology and Public Health (CIBERESP), Madrid, Spain; Department of Epidemiology, Regional Health Council, IMIB-Arrixaca, Murcia University, Murcia, Spain.
- 700 1_
- $a Sánchez, Maria-José $u Escuela Andaluza de Salud Pública, CIBER de Epidemiología y Salud Pública, Granada, Spain.
- 700 1_
- $a Palli, Domenico $u Cancer Risk Factors and Life-Style Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network - ISPRO, Florence, Italy.
- 700 1_
- $a Kühn, Tilman $u Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
- 700 1_
- $a Murphy, Neil $u Section of Nutrition and Metabolism, International Agency for Research on Cancer, Lyon, France.
- 700 1_
- $a Cross, Amanda J $u School of Public Health, Imperial College London, London, UK.
- 700 1_
- $a Burnett-Hartman, Andrea N $u Institute for Health Research, Kaiser Permanente Colorado, Aurora, Colorado.
- 700 1_
- $a Chanock, Stephen J $u Department of Epidemiology, University of Washington School of Public Health, Seattle, Washington.
- 700 1_
- $a de la Chapelle, Albert $u Department of Cancer Biology and Genetics, Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio.
- 700 1_
- $a Easton, Douglas F $u Department of Medicine, Weill Cornell Medical College, New York, New York.
- 700 1_
- $a Elliott, Faye $u Leeds Institute of Cancer and Pathology, University of Leeds, Leeds, UK.
- 700 1_
- $a English, Dallas R $u Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia; Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.
- 700 1_
- $a Feskens, Edith J M $u Division of Human Nutrition and Health, Wageningen University & Research, Wageningen, The Netherlands.
- 700 1_
- $a FitzGerald, Liesel M $u Cancer Epidemiology and Intelligence Division, Cancer Council Victoria, Melbourne, Victoria, Australia; Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia.
- 700 1_
- $a Goodman, Phyllis J $u SWOG Statistical Center, Fred Hutchinson Cancer Research Center, Seattle, Washington.
- 700 1_
- $a Hopper, John L $u Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia; Department of Epidemiology, School of Public Health and Institute of Health and Environment, Seoul National University, Seoul, South Korea.
- 700 1_
- $a Hudson, Thomas J $u Ontario Institute for Cancer Research, Toronto, Ontario, Canada.
- 700 1_
- $a Hunter, David J $u Department of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, Boston, Massachusetts; Nuffield Department of Population Health, University of Oxford, Oxford, UK.
- 700 1_
- $a Jacobs, Eric J $u Behavioral and Epidemiology Research Group, American Cancer Society, Atlanta, Georgia.
- 700 1_
- $a Joshu, Corinne E $u Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.
- 700 1_
- $a Küry, Sébastien $u Cancer Epidemiology and Intelligence Division, Cancer Council Victoria, Melbourne, Victoria, Australia.
- 700 1_
- $a Markowitz, Sanford D $u Institute of Environmental Medicine, Karolinska Institute, Stockholm, Sweden.
- 700 1_
- $a Milne, Roger L $u Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia; Cancer Epidemiology and Intelligence Division, Cancer Council Victoria, Melbourne, Victoria, Australia.
- 700 1_
- $a Platz, Elizabeth A $u Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.
- 700 1_
- $a Rennert, Gad $u Department of Community Medicine and Epidemiology, Lady Davis Carmel Medical Center, Haifa, Israel; Ruth and Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel; Clalit National Cancer Control Center, Haifa, Israel.
- 700 1_
- $a Rennert, Hedy S $u Department of Community Medicine and Epidemiology, Lady Davis Carmel Medical Center, Haifa, Israel; Ruth and Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel; Clalit National Cancer Control Center, Haifa, Israel.
- 700 1_
- $a Schumacher, Fredrick R $u Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, Ohio.
- 700 1_
- $a Sandler, Robert S $u Center for Gastrointestinal Biology and Disease, University of North Carolina, Chapel Hill, North Carolina.
- 700 1_
- $a Seminara, Daniela $u Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, Maryland.
- 700 1_
- $a Tangen, Catherine M $u SWOG Statistical Center, Fred Hutchinson Cancer Research Center, Seattle, Washington.
- 700 1_
- $a Thibodeau, Stephen N $u Division of Laboratory Genetics, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota.
- 700 1_
- $a Toland, Amanda E $u Department of Cancer Biology and Genetics, Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio.
- 700 1_
- $a van Duijnhoven, Franzel J B $u Division of Human Nutrition and Health, Wageningen University & Research, Wageningen, The Netherlands.
- 700 1_
- $a Visvanathan, Kala $u Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.
- 700 1_
- $a Vodickova, Ludmila $u Department of Molecular Biology of Cancer, Institute of Experimental Medicine of the Czech Academy of Sciences, Prague, Czech Republic; Institute of Biology and Medical Genetics, First Faculty of Medicine, Charles University, Prague, Czech Republic; Faculty of Medicine and Biomedical Center in Pilsen, Charles University, Pilsen, Czech Republic.
- 700 1_
- $a Potter, John D $u Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.
- 700 1_
- $a Männistö, Satu $u Department of Public Health Solutions, National Institute for Health and Welfare, Helsinki, Finland.
- 700 1_
- $a Weigl, Korbinian $u Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany; Medical Faculty, University of Heidelberg, Heidelberg, Germany.
- 700 1_
- $a Figueiredo, Jane $u Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California; Department of Medicine, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California.
- 700 1_
- $a Martín, Vicente $u CIBER in Epidemiology and Public Health (CIBERESP), Madrid, Spain; Biomedicine Institute (IBIOMED), University of León, León, Spain.
- 700 1_
- $a Larsson, Susanna C $u Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.
- 700 1_
- $a Parfrey, Patrick S $u The Clinical Epidemiology Unit, Memorial University Medical School, St. John's, Newfoundland, Canada.
- 700 1_
- $a Huang, Wen-Yi $u Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
- 700 1_
- $a Lenz, Heinz-Josef $u Division of Medical Oncology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California.
- 700 1_
- $a Castelao, Jose E $u Instituto de Investigación Sanitaria Galicia Sur (IISGS), Xerencia de Xestion Integrada de Vigo-SERGAS, Oncology and Genetics Unit, Vigo, Spain.
- 700 1_
- $a Gago-Dominguez, Manuela $u Genomic Medicine Group, Galician Foundation of Genomic Medicine, Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), Complejo Hospitalario Universitario de Santiago, SERGAS, Santiago de Compostela, Spain; Moores Cancer Center, University of California San Diego, La Jolla, California.
- 700 1_
- $a Muñoz-Garzón, Victor $u Radiotherapy Department, Complejo Hospitalario Universitario de Vigo, SERGAS, Vigo, Spain.
- 700 1_
- $a Mancao, Christoph $u Genentech, Inc., Basel, Switzerland.
- 700 1_
- $a Haiman, Christopher A $u Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California.
- 700 1_
- $a Wilkens, Lynne R $u Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii.
- 700 1_
- $a Siegel, Erin $u Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.
- 700 1_
- $a Barry, Elizabeth $u Department of Epidemiology, Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire.
- 700 1_
- $a Younghusband, Ban $u Memorial University of Newfoundland, Discipline of Genetics, St. John's, Newfoundland, Canada.
- 700 1_
- $a Van Guelpen, Bethany $u Wallenberg Centre for Molecular Medicine, Umeå University, Umeå, Sweden; Department of Radiation Sciences, Oncology Unit, Umeå University, Umeå, Sweden.
- 700 1_
- $a Harlid, Sophia $u Department of Radiation Sciences, Oncology Unit, Umeå University, Umeå, Sweden.
- 700 1_
- $a Zeleniuch-Jacquotte, Anne $u Division of Epidemiology, Department of Population Health, New York University School of Medicine, New York, New York.
- 700 1_
- $a Liang, Peter S $u Department of Medicine, New York University School of Medicine, New York, New York.
- 700 1_
- $a Du, Mengmeng $u Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York.
- 700 1_
- $a Casey, Graham $u Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia.
- 700 1_
- $a Lindor, Noralane M $u Department of Health Science Research, Mayo Clinic, Scottsdale, Arizona.
- 700 1_
- $a Le Marchand, Loic $u Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii.
- 700 1_
- $a Gallinger, Steven J $u Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada.
- 700 1_
- $a Jenkins, Mark A $u Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia.
- 700 1_
- $a Newcomb, Polly A $u Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington; School of Public Health, University of Washington, Seattle, Washington.
- 700 1_
- $a Gruber, Stephen B $u Center for Precision Medicine & Department of Medical Oncology and Therapeutics Research, City of Hope National Medical Center, Duarte, California.
- 700 1_
- $a Schoen, Robert E $u Department of Medicine and Epidemiology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.
- 700 1_
- $a Hampel, Heather $u Division of Human Genetics, Department of Internal Medicine, The Ohio State University Comprehensive Cancer Center, Columbus, Ohio.
- 700 1_
- $a Corley, Douglas A $u Division of Research, Kaiser Permanente Northern California, Oakland, California.
- 700 1_
- $a Hsu, Li $u Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington; Department of Biostatistics, University of Washington, Seattle, Washington.
- 700 1_
- $a Peters, Ulrike $u Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington; Memorial University of Newfoundland, Discipline of Genetics, St. John's, Newfoundland, Canada. Electronic address: upeters@fredhutch.org.
- 700 1_
- $a Hayes, Richard B $u Division of Epidemiology, Department of Population Health, New York University School of Medicine, New York, New York. Electronic address: richard.b.hayes@nyulangone.org.
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