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Variations in hemoglobin measurement and eligibility criteria across blood donation services are associated with differing low-hemoglobin deferral rates: a BEST Collaborative study
S. Zalpuri, B. Romeijn, E. Allara, M. Goldman, H. Kamel, J. Gorlin, R. Vassallo, Y. Grégoire, N. Goto, P. Flanagan, J. Speedy, A. Buser, JM. Kutner, K. Magnussen, J. Castrén, L. Culler, H. Sussmann, FJ. Prinsze, K. Belanger, V. Compernolle, P....
Language English Country United States
Document type Journal Article
Grant support
RG/13/13/30194
British Heart Foundation - United Kingdom
RG/18/13/33946
British Heart Foundation - United Kingdom
PubMed
32034925
DOI
10.1111/trf.15676
Knihovny.cz E-resources
- MeSH
- Time Factors MeSH
- Blood Donors statistics & numerical data MeSH
- Hematologic Tests MeSH
- Hemoglobins metabolism MeSH
- Blood Transfusion methods MeSH
- Humans MeSH
- Surveys and Questionnaires MeSH
- Donor Selection MeSH
- Iron metabolism MeSH
- Check Tag
- Humans MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
BACKGROUND: Determination of blood donor hemoglobin (Hb) levels is a pre-requisite to ensure donor safety and blood product quality. We aimed to identify Hb measurement practices across blood donation services and to what extent differences associate with low-Hb deferral rates. METHODS: An online survey was performed among Biomedical Excellence for Safer Transfusion (BEST) Collaborative members, extended with published data. Multivariable negative-binomial regression models were built to estimate adjusted associations of minimum donation intervals, Hb cut-offs (high, ≥13.5 g/dL in men or ≥ 12.5 g/dL in women, vs. lower values), iron monitoring (yes/no), providing or prescribing iron supplementation (yes/no), post-versus pre-donation Hb measurement and geographical location (Asian vs. rest), with low-Hb deferral rates. RESULTS: Data were included from 38 blood services. Low-Hb deferral rates varied from 0.11% to 8.81% among men and 0.84% to 31.85% among women. Services with longer minimum donation intervals had significantly lower deferral rates among both women (rate ratio, RR 0.53, 95%CI 0.33-0.84) and men (RR 0.53, 95%CI 0.31-0.90). In women, iron supplementation was associated with lower Hb deferral rates (RR 0.47, 95%CI 0.23-0.94). Finally, being located in Asia was associated with higher low-Hb deferral rates; RR 9.10 (95%CI 3.89-21.27) for women and 6.76 (95%CI 2.45-18.68) for men. CONCLUSION: Differences in Hb measurement and eligibility criteria, particularly longer donation intervals and iron supplementation in women, are associated with variations in low-Hb deferral rates. These insights could help improve both blood donation service efficiency and donor care.
American Red Cross Washington D C Washington
Australian Red Cross Blood Service Adelaide South Australia Australia
Blood Assurance Inc Chattanooga Tennessee
Blood Centre and Laboratory Medicine Innlandet Hospital Lillehammer Oppland Norway
Carter BloodCare Bedford Texas
Centro Vasco de Transfusion y Tejidos Humanos Galdakao Biscay Spain
Community Blood Center of the Carolinas Charlotte North Carolina
Department of Public Health and Primary Care University of Cambridge Cambridge United Kingdom
Division of Transfusion Medicine Mayo Clinic Rochester New York
Donor Studies Department of Donor Medicine Research Sanquin Research Amsterdam The Netherlands
Établissement Français du Sang Paris Île de France France
Finnish Red Cross Blood Service Helsinki Finland
German Red Cross Springe Lower Saxony Germany
Health Sciences Authority Blood Services Group Singapore Singapore
Hong Kong Red Cross Blood Transfusion Service Kowloon Hong Kong SAR China
Hospital Israelita Albert Einstein Sao Paulo Brazil
Hospital Sirio Libanes Blood Bank São Paulo Brazil
LifeShare Blood Centers Shreveport Louisiana
Medical Affairs and Innovation Héma Québec Quebec City Canada
Medical Services and Innovation Canadian Blood Services Ottawa Ontario Canada
Michigan Blood Saginaw Michigan
Military University Hospital Prague Czech Republic Prague Bohemia
National Institutes of Health Clinical Center Bethesda Maryland
New Zealand Blood Service Auckland New Zealand
Physician Services Innovative Blood Centers St Paul Minnesota
Red Cross Flanders Ghent East Flanders Belgium
Regional Blood Transfusion Service Swiss Red Cross Basel Switzerland
Shepeard Community Blood Center Augusta Georgia
References provided by Crossref.org
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- $a BACKGROUND: Determination of blood donor hemoglobin (Hb) levels is a pre-requisite to ensure donor safety and blood product quality. We aimed to identify Hb measurement practices across blood donation services and to what extent differences associate with low-Hb deferral rates. METHODS: An online survey was performed among Biomedical Excellence for Safer Transfusion (BEST) Collaborative members, extended with published data. Multivariable negative-binomial regression models were built to estimate adjusted associations of minimum donation intervals, Hb cut-offs (high, ≥13.5 g/dL in men or ≥ 12.5 g/dL in women, vs. lower values), iron monitoring (yes/no), providing or prescribing iron supplementation (yes/no), post-versus pre-donation Hb measurement and geographical location (Asian vs. rest), with low-Hb deferral rates. RESULTS: Data were included from 38 blood services. Low-Hb deferral rates varied from 0.11% to 8.81% among men and 0.84% to 31.85% among women. Services with longer minimum donation intervals had significantly lower deferral rates among both women (rate ratio, RR 0.53, 95%CI 0.33-0.84) and men (RR 0.53, 95%CI 0.31-0.90). In women, iron supplementation was associated with lower Hb deferral rates (RR 0.47, 95%CI 0.23-0.94). Finally, being located in Asia was associated with higher low-Hb deferral rates; RR 9.10 (95%CI 3.89-21.27) for women and 6.76 (95%CI 2.45-18.68) for men. CONCLUSION: Differences in Hb measurement and eligibility criteria, particularly longer donation intervals and iron supplementation in women, are associated with variations in low-Hb deferral rates. These insights could help improve both blood donation service efficiency and donor care.
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