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European consensus-based interdisciplinary guideline for melanoma. Part 1: Diagnostics - Update 2019
C. Garbe, T. Amaral, K. Peris, A. Hauschild, P. Arenberger, L. Bastholt, V. Bataille, V. Del Marmol, B. Dréno, MC. Fargnoli, JJ. Grob, C. Höller, R. Kaufmann, A. Lallas, C. Lebbé, J. Malvehy, M. Middleton, D. Moreno-Ramirez, G. Pellacani, P....
Language English Country Great Britain
Document type Journal Article
- MeSH
- Diagnostic Imaging standards MeSH
- European Union MeSH
- Combined Modality Therapy MeSH
- Consensus MeSH
- Humans MeSH
- Melanoma classification diagnosis therapy MeSH
- Interdisciplinary Communication * MeSH
- Practice Guidelines as Topic standards MeSH
- Neoplasm Staging MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
Cutaneous melanoma (CM) is potentially the most dangerous form of skin tumor and causes 90% of skin cancer mortality. A unique collaboration of multidisciplinary experts from the European Dermatology Forum (EDF), the European Association of Dermato-Oncology (EADO), and the European Organization of Research and Treatment of Cancer (EORTC) was formed to make recommendations on CM diagnosis and treatment, based on systematic literature reviews and the experts' experience. The diagnosis of melanoma can be made clinically and shall always be confirmed through dermatoscopy. If a melanoma is suspected, a histopathological examination is required. Sequential digital dermatoscopy and full-body photography can be used in risk persons to detect the development of melanomas at an earlier stage. Where available, confocal reflectance microscopy can improve clinical diagnosis in special cases. Melanoma shall be classified according to the 8th version of the AJCC classification. Thin melanomas up to 0.8 mm tumor thickness does not require further imaging diagnostics. From stage IB onwards, examinations with lymph node sonography are recommended, but no further imaging examinations. From stage IIC whole-body examinations with CT or PET-CT in combination with brain MRI are recommended. From stage III and higher, mutation testing is recommended, particularly for BRAF V600 mutation. It is important to provide a structured follow-up to detect relapses and secondary primary melanomas as early as possible. There is no evidence to support the frequency and extent of examinations. A stage-based follow-up scheme is proposed, which, according to the experience of the guideline group, covers the minimum requirements; further studies may be considered. This guideline is valid until the end of 2021.
1st Department of Dermatology Aristotle University Thessaloniki Greece
Center for Dermatooncology Department of Dermatology Eberhard Karls University Tuebingen Germany
Department of Dermatology Erasme Hospital Université Libre de Bruxelles Brussels Belgium
Department of Dermatology Medical University of Vienna Austria
Department of Dermatology University Hospital Schleswig Holstein Campus Kiel Kiel Germany
Department of Dermatology University of L'Aquila Italy
Department of Dermatology Venerology and Allergology Frankfurt University Hospital Frankfurt Germany
Department of Oncology Odense University Hospital Denmark
Dermatology Clinic Maggiore Hospital University of Trieste Trieste Italy
Dermatology Department CHU Nantes CIC 1413 CRCINA University Nantes Nantes France
Dermatology Unit University of Modena and Reggio Emilia Modena Italy
Fondazione Policlinico Universitario A Gemelli IRCCS Rome Italy
Institute of Dermatology Università Cattolica Rome Italy
Medical and Surgical Dermatology Service Hospital Universitario Virgen Macarena Sevilla Spain
Melanoma Unit Department of Dermatology Hospital Clinic IDIBAPS Barcelona Spain
NIHR Biomedical Research Center University of Oxford UK
Portuguese Air Force Health Care Direction Lisbon Portugal
Princess Máxima Center 3584 CS Utrecht the Netherlands
References provided by Crossref.org
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