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BIOPHYSICAL SIMULATION TOOL PARTRAC: MODELLING PROTON BEAMS AT THERAPY-RELEVANT ENERGIES
W. Friedland, P. Kundrát, J. Becker, M. Eidemüller,
Language English Country Great Britain
Document type Journal Article
PubMed
31808536
DOI
10.1093/rpd/ncz197
Knihovny.cz E-resources
- MeSH
- Algorithms MeSH
- DNA radiation effects MeSH
- DNA Breaks, Double-Stranded radiation effects MeSH
- Linear Energy Transfer MeSH
- Monte Carlo Method MeSH
- Computer Simulation * MeSH
- DNA Damage MeSH
- Proton Therapy MeSH
- Protons MeSH
- Relative Biological Effectiveness MeSH
- Software MeSH
- Water MeSH
- Computational Biology MeSH
- Publication type
- Journal Article MeSH
The biophysical simulation tool PARTRAC has been primarily developed to model radiation physics, chemistry and biology on nanometre to micrometre scales. However, the tool can be applied in simulating radiation effects in an event-by-event manner over macroscopic volumes as well. Benchmark simulations are reported showing that PARTRAC does reproduce the macroscopic Bragg peaks of proton beams, although the penetration depths are underestimated by a few per cent for high-energy beams. PARTRAC also quantifies the increase in DNA damage and its complexity along the beam penetration depth. Enhanced biological effectiveness is predicted in particular within distal Bragg peak parts of therapeutic proton beams.
References provided by Crossref.org
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