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Cerebellar parcellation in schizophrenia and bipolar disorder
C. Laidi, T. Hajek, F. Spaniel, M. Kolenic, MA. d'Albis, S. Sarrazin, JF. Mangin, E. Duchesnay, P. Brambilla, M. Wessa, J. Linke, M. Polosan, P. Favre, AL. Versace, ML. Phillips, JV. Manjon, JE. Romero, F. Hozer, M. Leboyer, P. Coupe, J. Houenou,
Jazyk angličtina Země Spojené státy americké
Typ dokumentu časopisecké články, multicentrická studie, Research Support, N.I.H., Extramural, práce podpořená grantem
Grantová podpora
ANR-11-IDEX-0004
Agence Nationale de la Recherche - International
ANR-11-INBS-006
Agence Nationale de la Recherche - International
ANR-14-CE35-0035
Agence Nationale de la Recherche - International
SFB636/C6 and We3638/3-1
Deutsche Forschungsgemeinschaft - International
NV16-32696A
Ministerstvo Zdravotnictví Ceské Republiky - International
NV16-32791A
Ministerstvo Zdravotnictví Ceské Republiky - International
R01 MH076971
NIMH NIH HHS - United States
159/03
Regione Veneto Italy - International
DGRV n. 4087
Regione Veneto Italy - International
NV16-32791A
MZ0
CEP - Centrální evidence projektů
NV16-32791A
MZ0
CEP - Centrální evidence projektů
Digitální knihovna NLK
Plný text - Článek
Plný text - Článek
NLK
Medline Complete (EBSCOhost)
od 2000-01-01 do Před 1 rokem
PubMed
31418816
DOI
10.1111/acps.13087
Knihovny.cz E-zdroje
- MeSH
- antimanika škodlivé účinky MeSH
- bipolární porucha diagnostické zobrazování farmakoterapie patologie MeSH
- dospělí MeSH
- kůra mozečku diagnostické zobrazování účinky léků patologie MeSH
- lidé středního věku MeSH
- lidé MeSH
- magnetická rezonanční tomografie MeSH
- mladý dospělý MeSH
- schizofrenie diagnostické zobrazování farmakoterapie patologie MeSH
- sloučeniny lithia škodlivé účinky MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladý dospělý MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- multicentrická studie MeSH
- práce podpořená grantem MeSH
- Research Support, N.I.H., Extramural MeSH
OBJECTIVE: The cerebellum is involved in cognitive processing and emotion control. Cerebellar alterations could explain symptoms of schizophrenia spectrum disorder (SZ) and bipolar disorder (BD). In addition, literature suggests that lithium might influence cerebellar anatomy. Our aim was to study cerebellar anatomy in SZ and BD, and investigate the effect of lithium. METHODS: Participants from 7 centers worldwide underwent a 3T MRI. We included 182 patients with SZ, 144 patients with BD, and 322 controls. We automatically segmented the cerebellum using the CERES pipeline. All outputs were visually inspected. RESULTS: Patients with SZ showed a smaller global cerebellar gray matter volume compared to controls, with most of the changes located to the cognitive part of the cerebellum (Crus II and lobule VIIb). This decrease was present in the subgroup of patients with recent-onset SZ. We did not find any alterations in the cerebellum in patients with BD. However, patients medicated with lithium had a larger size of the anterior cerebellum, compared to patients not treated with lithium. CONCLUSION: Our multicenter study supports a distinct pattern of cerebellar alterations in SZ and BD.
Department of Clinical Psychology and Neuropsychology Johannes Gutenberg University Mainz Germany
National Institute of Mental Health Klecany Czech Republic
Citace poskytuje Crossref.org
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