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The Association Between Familial Risk and Brain Abnormalities Is Disease Specific: An ENIGMA-Relatives Study of Schizophrenia and Bipolar Disorder
SMC. de Zwarte, RM. Brouwer, I. Agartz, M. Alda, A. Aleman, KI. Alpert, CE. Bearden, A. Bertolino, C. Bois, A. Bonvino, E. Bramon, EEL. Buimer, W. Cahn, DM. Cannon, TD. Cannon, X. Caseras, J. Castro-Fornieles, Q. Chen, Y. Chung, E. De la Serna,...
Jazyk angličtina Země Spojené státy americké
Typ dokumentu časopisecké články, metaanalýza, Research Support, N.I.H., Extramural, Research Support, N.I.H., Intramural, práce podpořená grantem, Research Support, U.S. Gov't, Non-P.H.S., studie na dvojčatech
Grantová podpora
P41 EB015922
NIBIB NIH HHS - United States
T32 MH073526
NIMH NIH HHS - United States
341717
CIHR - Canada
R01 MH084803
NIMH NIH HHS - United States
R01 MH085667
NIMH NIH HHS - United States
G0901310
Medical Research Council - United Kingdom
R03 MH105808
NIMH NIH HHS - United States
106469
CIHR - Canada
R01 MH113619
NIMH NIH HHS - United States
085475/B/08/Z
Wellcome Trust - United Kingdom
R01 MH111671
NIMH NIH HHS - United States
R01 MH116147
NIMH NIH HHS - United States
R01 MH080912
NIMH NIH HHS - United States
103703
CIHR - Canada
T32 AG058507
NIA NIH HHS - United States
U54 EB020403
NIBIB NIH HHS - United States
R01 MH117601
NIMH NIH HHS - United States
R01 MH052857
NIMH NIH HHS - United States
R01 EB020062
NIBIB NIH HHS - United States
U01 MH097435
NIMH NIH HHS - United States
064971
Wellcome Trust - United Kingdom
PDA/02/06/016
Department of Health - United Kingdom
MR/L010305/1
Medical Research Council - United Kingdom
- MeSH
- bipolární porucha * genetika patologie MeSH
- dospělí MeSH
- genetická predispozice k nemoci * MeSH
- kohortové studie MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladý dospělý MeSH
- mozek patologie MeSH
- schizofrenie * genetika patologie MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladý dospělý MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- metaanalýza MeSH
- práce podpořená grantem MeSH
- Research Support, N.I.H., Extramural MeSH
- Research Support, N.I.H., Intramural MeSH
- Research Support, U.S. Gov't, Non-P.H.S. MeSH
- studie na dvojčatech MeSH
BACKGROUND: Schizophrenia and bipolar disorder share genetic liability, and some structural brain abnormalities are common to both conditions. First-degree relatives of patients with schizophrenia (FDRs-SZ) show similar brain abnormalities to patients, albeit with smaller effect sizes. Imaging findings in first-degree relatives of patients with bipolar disorder (FDRs-BD) have been inconsistent in the past, but recent studies report regionally greater volumes compared with control subjects. METHODS: We performed a meta-analysis of global and subcortical brain measures of 6008 individuals (1228 FDRs-SZ, 852 FDRs-BD, 2246 control subjects, 1016 patients with schizophrenia, 666 patients with bipolar disorder) from 34 schizophrenia and/or bipolar disorder family cohorts with standardized methods. Analyses were repeated with a correction for intracranial volume (ICV) and for the presence of any psychopathology in the relatives and control subjects. RESULTS: FDRs-BD had significantly larger ICV (d = +0.16, q < .05 corrected), whereas FDRs-SZ showed smaller thalamic volumes than control subjects (d = -0.12, q < .05 corrected). ICV explained the enlargements in the brain measures in FDRs-BD. In FDRs-SZ, after correction for ICV, total brain, cortical gray matter, cerebral white matter, cerebellar gray and white matter, and thalamus volumes were significantly smaller; the cortex was thinner (d < -0.09, q < .05 corrected); and third ventricle was larger (d = +0.15, q < .05 corrected). The findings were not explained by psychopathology in the relatives or control subjects. CONCLUSIONS: Despite shared genetic liability, FDRs-SZ and FDRs-BD show a differential pattern of structural brain abnormalities, specifically a divergent effect in ICV. This may imply that the neurodevelopmental trajectories leading to brain anomalies in schizophrenia or bipolar disorder are distinct.
Cardiff University Brain Research Imaging Centre Cardiff University United Kingdom
Center for Neurobehavioral Genetics University of California Los Angeles Los Angeles California
Center for the Neurobiology of Learning and Memory University of California Irvine Irvine California
Department of Experimental and Clinical Medicine Università Politecnica delle Marche Ancona Italy
Department of Medical Epidemiology and Biostatistics Karolinska Institutet Stockholm Sweden
Department of Neurosciences Health Sciences Institute Dokuz Eylül University Izmir Turkey
Department of Psychiatry 3rd Faculty of Medicine Charles University Prague Czech Republic
Department of Psychiatry and Behavioral Sciences Mercer University School of Medicine Macon Georgia
Department of Psychiatry and Behavioral Sciences University of New Mexico Albuquerque New Mexico
Department of Psychiatry Cigli State Hospital Izmir Turkey
Department of Psychiatry Dalhousie University Halifax Nova Scotia Canada
Department of Psychiatry Diakonhjemmet Hospital Oslo Norway
Department of Psychiatry Faculty of Medicine Izmir Katip Çelebi University Izmir Turkey
Department of Psychiatry Faculty of Medicine Izmir Turkey
Department of Psychiatry Icahn School of Medicine at Mount Sinai New York New York
Department of Psychiatry Yale University School of Medicine New Haven Connecticut
Department of Psychology Bilkent University Ankara Turkey
Department of Psychology Georgia State University Atlanta Georgia
Department of Psychology University of California Los Angeles Los Angeles California
Department of Psychology University of Hong Kong Hong Kong China
Department of Psychology University of Toronto Toronto Ontario Canada
Department of Psychology Yale University New Haven Connecticut United Kingdom
Department of Radiology The Johns Hopkins University School of Medicine Baltimore Maryland
Division of Mental Health and Addiction Oslo University Hospital Oslo Norway
Division of Psychiatry Royal Edinburgh Hospital University of Edinburgh Edinburgh United Kingdom
Early Psychosis Unit Department of Psychiatry Academic Medical Center Amsterdam Netherlands
Graduate Department of Psychological Clinical Science University of Toronto Toronto Ontario Canada
Harvard Medical School Boston Massachusetts
Lieber Institute for Brain Development Baltimore Maryland
MRC Centre for Neuropsychiatric Genetics and Genomics Cardiff University United Kingdom
National Institute of Mental Health Klecany Czech Republic
Neuroscience Institute Georgia State University Atlanta Georgia
Neuroscience Research Australia Sydney Australia
Olin Neuropsychiatry Research Center Institute of Living Hartford Hospital Hartford Connecticut
School of Medical Sciences University of New South Wales Sydney Australia
School of Psychiatry University of New South Wales Sydney Australia
SoCAT LAB Department of Psychiatry School of Medicine Ege University Bornova Izmir Turkey
Citace poskytuje Crossref.org
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- $a de Zwarte, Sonja M C $u Department of Psychiatry, University Medical Center Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands. Electronic address: s.m.c.dezwarte@umcutrecht.nl.
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- $a The Association Between Familial Risk and Brain Abnormalities Is Disease Specific: An ENIGMA-Relatives Study of Schizophrenia and Bipolar Disorder / $c SMC. de Zwarte, RM. Brouwer, I. Agartz, M. Alda, A. Aleman, KI. Alpert, CE. Bearden, A. Bertolino, C. Bois, A. Bonvino, E. Bramon, EEL. Buimer, W. Cahn, DM. Cannon, TD. Cannon, X. Caseras, J. Castro-Fornieles, Q. Chen, Y. Chung, E. De la Serna, A. Di Giorgio, GE. Doucet, MC. Eker, S. Erk, SC. Fears, SF. Foley, S. Frangou, A. Frankland, JM. Fullerton, DC. Glahn, VM. Goghari, AL. Goldman, AS. Gonul, O. Gruber, L. de Haan, T. Hajek, EL. Hawkins, A. Heinz, MHJ. Hillegers, HE. Hulshoff Pol, CM. Hultman, M. Ingvar, V. Johansson, EG. Jönsson, F. Kane, MJ. Kempton, MMG. Koenis, M. Kopecek, L. Krabbendam, B. Krämer, SM. Lawrie, RK. Lenroot, M. Marcelis, JC. Marsman, VS. Mattay, C. McDonald, A. Meyer-Lindenberg, S. Michielse, PB. Mitchell, D. Moreno, RM. Murray, B. Mwangi, P. Najt, E. Neilson, J. Newport, J. van Os, B. Overs, A. Ozerdem, MM. Picchioni, A. Richter, G. Roberts, AS. Aydogan, PR. Schofield, F. Simsek, JC. Soares, G. Sugranyes, T. Toulopoulou, G. Tronchin, H. Walter, L. Wang, DR. Weinberger, HC. Whalley, N. Yalin, OA. Andreassen, CRK. Ching, TGM. van Erp, JA. Turner, N. Jahanshad, PM. Thompson, RS. Kahn, NEM. van Haren,
- 520 9_
- $a BACKGROUND: Schizophrenia and bipolar disorder share genetic liability, and some structural brain abnormalities are common to both conditions. First-degree relatives of patients with schizophrenia (FDRs-SZ) show similar brain abnormalities to patients, albeit with smaller effect sizes. Imaging findings in first-degree relatives of patients with bipolar disorder (FDRs-BD) have been inconsistent in the past, but recent studies report regionally greater volumes compared with control subjects. METHODS: We performed a meta-analysis of global and subcortical brain measures of 6008 individuals (1228 FDRs-SZ, 852 FDRs-BD, 2246 control subjects, 1016 patients with schizophrenia, 666 patients with bipolar disorder) from 34 schizophrenia and/or bipolar disorder family cohorts with standardized methods. Analyses were repeated with a correction for intracranial volume (ICV) and for the presence of any psychopathology in the relatives and control subjects. RESULTS: FDRs-BD had significantly larger ICV (d = +0.16, q < .05 corrected), whereas FDRs-SZ showed smaller thalamic volumes than control subjects (d = -0.12, q < .05 corrected). ICV explained the enlargements in the brain measures in FDRs-BD. In FDRs-SZ, after correction for ICV, total brain, cortical gray matter, cerebral white matter, cerebellar gray and white matter, and thalamus volumes were significantly smaller; the cortex was thinner (d < -0.09, q < .05 corrected); and third ventricle was larger (d = +0.15, q < .05 corrected). The findings were not explained by psychopathology in the relatives or control subjects. CONCLUSIONS: Despite shared genetic liability, FDRs-SZ and FDRs-BD show a differential pattern of structural brain abnormalities, specifically a divergent effect in ICV. This may imply that the neurodevelopmental trajectories leading to brain anomalies in schizophrenia or bipolar disorder are distinct.
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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