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A Systematic Review and International Web-Based Survey of Randomized Controlled Trials in the Perioperative and Critical Care Setting: Interventions Increasing Mortality
C. Sartini, V. Lomivorotov, A. Pisano, H. Riha, M. Baiardo Redaelli, JC. Lopez-Delgado, M. Pieri, L. Hajjar, E. Fominskiy, V. Likhvantsev, L. Cabrini, N. Bradic, D. Avancini, CY. Wang, R. Lembo, M. Novikov, G. Paternoster, G. Gazivoda, G. Alvaro,...
Jazyk angličtina Země Spojené státy americké
Typ dokumentu časopisecké články, systematický přehled
- MeSH
- internet MeSH
- kardiochirurgické výkony škodlivé účinky mortalita MeSH
- kritický stav mortalita terapie MeSH
- lékaři * MeSH
- lidé MeSH
- mortalita trendy MeSH
- péče o pacienty v kritickém stavu metody MeSH
- perioperační péče metody MeSH
- průzkumy a dotazníky * MeSH
- randomizované kontrolované studie jako téma metody MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- systematický přehled MeSH
OBJECTIVE: Reducing mortality is a key target in critical care and perioperative medicine. The authors aimed to identify all nonsurgical interventions (drugs, techniques, strategies) shown by randomized trials to increase mortality in these clinical settings. DESIGN: A systematic review of the literature followed by a consensus-based voting process. SETTING: A web-based international consensus conference. PARTICIPANTS: Two hundred fifty-one physicians from 46 countries. INTERVENTIONS: The authors performed a systematic literature search and identified all randomized controlled trials (RCTs) showing a significant increase in unadjusted landmark mortality among surgical or critically ill patients. The authors reviewed such studies during a meeting by a core group of experts. Studies selected after such review advanced to web-based voting by clinicians in relation to agreement, clinical practice, and willingness to include each intervention in international guidelines. MEASUREMENTS AND MAIN RESULTS: The authors selected 12 RCTs dealing with 12 interventions increasing mortality: diaspirin-crosslinked hemoglobin (92% of agreement among web voters), overfeeding, nitric oxide synthase inhibitor in septic shock, human growth hormone, thyroxin in acute kidney injury, intravenous salbutamol in acute respiratory distress syndrome, plasma-derived protein C concentrate, aprotinin in high-risk cardiac surgery, cysteine prodrug, hypothermia in meningitis, methylprednisolone in traumatic brain injury, and albumin in traumatic brain injury (72% of agreement). Overall, a high consistency (ranging from 80% to 90%) between agreement and clinical practice was observed. CONCLUSION: The authors identified 12 clinical interventions showing increased mortality supported by randomized controlled trials with nonconflicting evidence, and wide agreement upon clinicians on a global scale.
Anaesthesia and Intensive Care Hospital Pulau Pinang Georgetown Malaysia
Anaesthesia and Intensive Care San Carlo Hospital Potenza Italy
Anaesthesia and Intensive Care University of Malaya Kuala Lumpur Malaysia
Anesthesia and Intensive Care A O U Città della salute e della Scienza Turin Italy
Anesthesia and Intensive Care Azienda Ospedaliera San Camillo Forlanini Rome Italy
AOU Mater Domini Germaneto Catanzaro Italy
Australian and New Zealand Intensive Care Research Centre Melbourne Australia
Center for Anesthesiology Beijing Anzhen Hospital Capital Medical University Beijing China
Department of Anaesthesia and Intensive Care Ospedale Cardinal Massaia di Asti Asti Italy
Department of Anesthesia and Intensive Care A O U Cittàdella Salute e della Scienza Turin Italy
Department of Anesthesia and Intensive Care IRCCS San Raffaele Scientific Institute Milan Italy
Department of Anesthesia and Intensive Care Unit Policlinico Duilio Casula AOU Cagliari Italy
Department of Medical Sciences and Public Health University of Cagliari Monserrato Italy
Division of Cardiac Anesthesia and Intensive Care Unit AORN dei Colli Monaldi Hospital Naples Italy
E Meshalkin National Medical Research Center Novosibirsk Russia
E O Ospedali Galliera Genova Italy and Università degli Studi di Pisa Italy
Hospital Santa Chiara Pisa Italy
Hospital Universitari de Bellvitge Barcelona Spain
Institute for Clinical and Experimental Medicine Prague Czech Republic
Institute of Cardiovascular Diseases Dedinje Belgrade Serbia
Instituto do Coracao do Hospital das Clinicas Sao Paulo Brazil
IRCCS Istituto Giannina Gaslini Ospedale Pediatrico Genoa Italy
S Antonio Hospital Padova Italy
Saint Petersburg State University Saint Petersburg Russia
San Raffaele Telethon Institute for Gene Therapy IRCCS San Raffaele Scientific Institute Milan Italy
Citace poskytuje Crossref.org
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- $a A Systematic Review and International Web-Based Survey of Randomized Controlled Trials in the Perioperative and Critical Care Setting: Interventions Increasing Mortality / $c C. Sartini, V. Lomivorotov, A. Pisano, H. Riha, M. Baiardo Redaelli, JC. Lopez-Delgado, M. Pieri, L. Hajjar, E. Fominskiy, V. Likhvantsev, L. Cabrini, N. Bradic, D. Avancini, CY. Wang, R. Lembo, M. Novikov, G. Paternoster, G. Gazivoda, G. Alvaro, A. Roasio, C. Wang, L. Severi, L. Pasin, P. Mura, M. Musu, S. Silvetti, CD. Votta, A. Belletti, F. Corradi, C. Brusasco, S. Tamà, L. Ruggeri, CY. Yong, D. Pasero, G. Mancino, S. Spadaro, M. Conte, R. Lobreglio, D. Di Fraja, E. Saporito, A. D'Amico, S. Sardo, A. Ortalda, A. Yavorovskiy, C. Riefolo, F. Monaco, R. Bellomo, A. Zangrillo, G. Landoni,
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