• Je něco špatně v tomto záznamu ?

High immune cytolytic activity in tumor-free tongue tissue confers better prognosis in patients with squamous cell carcinoma of the oral tongue

X. Gu, L. Boldrup, PJ. Coates, R. Fahraeus, L. Wang, T. Wilms, L. Norberg-Spaak, N. Sgaramella, K. Nylander,

. 2019 ; 5 (4) : 240-247. [pub] 20190719

Jazyk angličtina Země Velká Británie

Typ dokumentu časopisecké články, práce podpořená grantem

Perzistentní odkaz   https://www.medvik.cz/link/bmc20025621

Immune cells and cytolytic activity within the tumor microenvironment are being intensively studied. Through transcriptome profiling, immune cell enumeration using the xCell tool and cytolytic activity quantification according to granzyme A (GZMA) and perforin (PRF1) mRNA levels, we investigated immunoreactivity in tumor and/or tumor-free tongue tissue samples from 31 patients with squamous cell carcinoma of the oral tongue and 14 healthy individuals (control tongue tissues). We found significantly altered immune cell compositions (p < 0.001) and elevated cytolytic activity (p < 0.001) in tumor compared to tumor-free samples, and altered infiltration of a subset of immune cells (e.g. CD8+ T cells, p < 0.01) as well as increased cytolytic activity (p < 0.001) in tumor-free compared to control samples. Controlling for patient age at diagnosis and tumor stage, Cox regression analysis showed that high cytolytic activity in tumor-free samples associated with improved disease-free survival (hazard ratio= 4.20, 95% CI = 1.09-16.20, p = 0.037). However, the degree of cytolytic activity in tumor samples did not provide prognostic information. Taken together, our results show the presence of cancer-related immune responses in clinically tumor-free tongue in patients with squamous cell carcinoma of the oral tongue. Measuring cytolytic activity in tumor-free tongue samples contralateral to tumor might thus be an effective approach to predict clinical outcome.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc20025621
003      
CZ-PrNML
005      
20201222154012.0
007      
ta
008      
201125s2019 xxk f 000 0|eng||
009      
AR
024    7_
$a 10.1002/cjp2.138 $2 doi
035    __
$a (PubMed)31237113
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xxk
100    1_
$a Gu, Xiaolian $u Department of Medical Biosciences/Pathology, Umeå University, Umeå, Sweden.
245    10
$a High immune cytolytic activity in tumor-free tongue tissue confers better prognosis in patients with squamous cell carcinoma of the oral tongue / $c X. Gu, L. Boldrup, PJ. Coates, R. Fahraeus, L. Wang, T. Wilms, L. Norberg-Spaak, N. Sgaramella, K. Nylander,
520    9_
$a Immune cells and cytolytic activity within the tumor microenvironment are being intensively studied. Through transcriptome profiling, immune cell enumeration using the xCell tool and cytolytic activity quantification according to granzyme A (GZMA) and perforin (PRF1) mRNA levels, we investigated immunoreactivity in tumor and/or tumor-free tongue tissue samples from 31 patients with squamous cell carcinoma of the oral tongue and 14 healthy individuals (control tongue tissues). We found significantly altered immune cell compositions (p < 0.001) and elevated cytolytic activity (p < 0.001) in tumor compared to tumor-free samples, and altered infiltration of a subset of immune cells (e.g. CD8+ T cells, p < 0.01) as well as increased cytolytic activity (p < 0.001) in tumor-free compared to control samples. Controlling for patient age at diagnosis and tumor stage, Cox regression analysis showed that high cytolytic activity in tumor-free samples associated with improved disease-free survival (hazard ratio= 4.20, 95% CI = 1.09-16.20, p = 0.037). However, the degree of cytolytic activity in tumor samples did not provide prognostic information. Taken together, our results show the presence of cancer-related immune responses in clinically tumor-free tongue in patients with squamous cell carcinoma of the oral tongue. Measuring cytolytic activity in tumor-free tongue samples contralateral to tumor might thus be an effective approach to predict clinical outcome.
650    _2
$a dospělí $7 D000328
650    _2
$a senioři $7 D000368
650    _2
$a senioři nad 80 let $7 D000369
650    _2
$a cytotoxicita imunologická $7 D003602
650    _2
$a přežití po terapii bez příznaků nemoci $7 D018572
650    _2
$a ženské pohlaví $7 D005260
650    _2
$a lidé $7 D006801
650    _2
$a mužské pohlaví $7 D008297
650    _2
$a lidé středního věku $7 D008875
650    _2
$a prognóza $7 D011379
650    _2
$a retrospektivní studie $7 D012189
650    _2
$a dlaždicobuněčné karcinomy hlavy a krku $x imunologie $x mortalita $7 D000077195
650    _2
$a nádory jazyka $x imunologie $x mortalita $x patologie $7 D014062
650    _2
$a nádorové mikroprostředí $x imunologie $7 D059016
650    _2
$a mladý dospělý $7 D055815
655    _2
$a časopisecké články $7 D016428
655    _2
$a práce podpořená grantem $7 D013485
700    1_
$a Boldrup, Linda $u Department of Medical Biosciences/Pathology, Umeå University, Umeå, Sweden.
700    1_
$a Coates, Philip J $u Regional Centre for Applied Molecular Oncology (RECAMO), Masaryk Memorial Cancer Institute, Brno, Czech Republic.
700    1_
$a Fahraeus, Robin $u Department of Medical Biosciences/Pathology, Umeå University, Umeå, Sweden. Regional Centre for Applied Molecular Oncology (RECAMO), Masaryk Memorial Cancer Institute, Brno, Czech Republic. Institute of Molecular Genetics, University Paris 7, St. Louis Hospital, Paris, France.
700    1_
$a Wang, Lixiao $u Department of Medical Biosciences/Pathology, Umeå University, Umeå, Sweden.
700    1_
$a Wilms, Torben $u Department of Clinical Sciences/ENT, Umeå University, Umeå, Sweden.
700    1_
$a Norberg-Spaak, Lena $u Department of Clinical Sciences/ENT, Umeå University, Umeå, Sweden.
700    1_
$a Sgaramella, Nicola $u Department of Medical Biosciences/Pathology, Umeå University, Umeå, Sweden.
700    1_
$a Nylander, Karin $u Department of Medical Biosciences/Pathology, Umeå University, Umeå, Sweden.
773    0_
$w MED00205747 $t The journal of pathology. Clinical research $x 2056-4538 $g Roč. 5, č. 4 (2019), s. 240-247
856    41
$u https://pubmed.ncbi.nlm.nih.gov/31237113 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y a $z 0
990    __
$a 20201125 $b ABA008
991    __
$a 20201222154008 $b ABA008
999    __
$a ok $b bmc $g 1599766 $s 1116307
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2019 $b 5 $c 4 $d 240-247 $e 20190719 $i 2056-4538 $m The journal of pathology. Clinical research $n J Pathol Clin Res $x MED00205747
LZP    __
$a Pubmed-20201125

Najít záznam

Citační ukazatele

Možnosti archivace