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Strong correlation between the rates of intrinsically antibiotic-resistant species and the rates of acquired resistance in Gram-negative species causing bacteraemia, EU/EEA, 2016
V. Jarlier, L. Diaz Högberg, OE. Heuer, J. Campos, T. Eckmanns, CG. Giske, H. Grundmann, AP. Johnson, G. Kahlmeter, J. Monen, A. Pantosti, GM. Rossolini, N. van de Sande-Bruinsma, A. Vatopoulos, D. Żabicka, H. Žemličková, DL. Monnet, GS....
Language English Country Sweden
Document type Journal Article
Grant support
001
World Health Organization - International
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- MeSH
- Acinetobacter drug effects MeSH
- Anti-Bacterial Agents pharmacology MeSH
- Drug Resistance, Bacterial drug effects MeSH
- Bacteremia drug therapy epidemiology MeSH
- Cephalosporins pharmacology MeSH
- Escherichia coli drug effects MeSH
- European Union MeSH
- Fluoroquinolones pharmacology MeSH
- Gram-Negative Bacterial Infections drug therapy epidemiology MeSH
- Gram-Negative Bacteria drug effects MeSH
- Carbapenems pharmacology MeSH
- Klebsiella pneumoniae drug effects MeSH
- Humans MeSH
- Microbial Sensitivity Tests MeSH
- Pseudomonas aeruginosa drug effects MeSH
- Sentinel Surveillance MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Geographicals
- Europe MeSH
BackgroundAntibiotic resistance, either intrinsic or acquired, is a major obstacle for treating bacterial infections.AimOur objective was to compare the country-specific species distribution of the four Gram-negative species Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa and Acinetobacter species and the proportions of selected acquired resistance traits within these species.MethodWe used data reported for 2016 to the European Antimicrobial Resistance Surveillance Network (EARS-Net) by 30 countries in the European Union and European Economic Area.ResultsThe country-specific species distribution varied considerably. While E. coli accounted for 31.9% to 81.0% (median: 69.0%) of all reported isolates, the two most common intrinsically resistant species P. aeruginosa and Acinetobacter spp. combined (PSEACI) accounted for 5.5% to 39.2% of isolates (median: 10.1%). Similarly, large national differences were noted for the percentages of acquired non-susceptibility to third-generation cephalosporins, carbapenems and fluoroquinolones. There was a strong positive rank correlation between the country-specific percentages of PSEACI and the percentages of non-susceptibility to the above antibiotics in all four species (rho > 0.75 for 10 of the 11 pairs of variables tested).ConclusionCountries with the highest proportion of P. aeruginosa and Acinetobacter spp. were also those where the rates of acquired non-susceptibility in all four studied species were highest. The differences are probably related to national differences in antibiotic consumption and infection prevention and control routines.
Clinical Microbiology Central Hospital Växjö Sweden
Department of Epidemiology and Clinical Microbiology National Medicines Institute Warsaw Poland
Department of Infectious Diseases Istituto Superiore di Sanità Rome Italy
Department of Public Health Policy School of Public Health University of West Attica Athens Greece
European Centre for Disease Prevention and Control Solna Sweden
National Infection Service Public Health England London United Kingdom
National Institute for Public Health and the Environment Bilthoven the Netherlands
Pan American Health Organization World Health Organization Washington DC United States
Robert Koch Institute Department for Infectious Disease Epidemiology Berlin Germany
References provided by Crossref.org
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- $a Jarlier, Vincent $u Assistance Publique - Hôpitaux de Paris, Pitié-Salpêtrière hospital, Laboratoire de Bactériologie-Hygiène, Paris, France. Sorbonne Universités (Paris 06) Inserm Centre d'Immunologie et des Maladies Infectieuses (CIMI), UMR 1135, Paris, France.
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- $a Strong correlation between the rates of intrinsically antibiotic-resistant species and the rates of acquired resistance in Gram-negative species causing bacteraemia, EU/EEA, 2016 / $c V. Jarlier, L. Diaz Högberg, OE. Heuer, J. Campos, T. Eckmanns, CG. Giske, H. Grundmann, AP. Johnson, G. Kahlmeter, J. Monen, A. Pantosti, GM. Rossolini, N. van de Sande-Bruinsma, A. Vatopoulos, D. Żabicka, H. Žemličková, DL. Monnet, GS. Simonsen, Ears-Net Participants,
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- $a BackgroundAntibiotic resistance, either intrinsic or acquired, is a major obstacle for treating bacterial infections.AimOur objective was to compare the country-specific species distribution of the four Gram-negative species Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa and Acinetobacter species and the proportions of selected acquired resistance traits within these species.MethodWe used data reported for 2016 to the European Antimicrobial Resistance Surveillance Network (EARS-Net) by 30 countries in the European Union and European Economic Area.ResultsThe country-specific species distribution varied considerably. While E. coli accounted for 31.9% to 81.0% (median: 69.0%) of all reported isolates, the two most common intrinsically resistant species P. aeruginosa and Acinetobacter spp. combined (PSEACI) accounted for 5.5% to 39.2% of isolates (median: 10.1%). Similarly, large national differences were noted for the percentages of acquired non-susceptibility to third-generation cephalosporins, carbapenems and fluoroquinolones. There was a strong positive rank correlation between the country-specific percentages of PSEACI and the percentages of non-susceptibility to the above antibiotics in all four species (rho > 0.75 for 10 of the 11 pairs of variables tested).ConclusionCountries with the highest proportion of P. aeruginosa and Acinetobacter spp. were also those where the rates of acquired non-susceptibility in all four studied species were highest. The differences are probably related to national differences in antibiotic consumption and infection prevention and control routines.
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- $a Eckmanns, Tim $u Robert Koch Institute, Department for Infectious Disease Epidemiology, Berlin, Germany.
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- $a Giske, Christian G $u Department of Clinical Microbiology, Karolinska University Hospital, Stockholm, Sweden. Department of Laboratory Medicine, Karolinska Institute, Stockholm, Sweden.
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- $a Grundmann, Hajo $u Medical Center - University of Freiburg, Department for Infection Prevention and Hospital Epidemiology, Freiburg, Germany.
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- $a Rossolini, Gian Maria $u Microbiology and Virology Unit, Florence Careggi University Hospital, Florence, Italy. Department of Experimental and Clinical Medicine, University of Florence, Italy.
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