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In vivo testing of a bioresorbable phosphate-based optical fiber

O. Podrazký, P. Peterka, I. Kašík, S. Vytykáčová, J. Proboštová, J. Mrázek, M. Kuneš, V. Závalová, V. Radochová, O. Lyutakov, E. Ceci-Ginistrelli, D. Pugliese, NG. Boetti, D. Janner, D. Milanese,

. 2019 ; 12 (7) : e201800397. [pub] 20190401

Language English Country Germany

Document type Journal Article, Research Support, Non-U.S. Gov't

Persistent link   https://www.medvik.cz/link/bmc20025802

Grant support
MP1401 European Cooperation in Science and Technology - International
15-33459A Ministerstvo Zdravotnictví Ceské Republiky - International
Interdepartmental Centre "PhotoNext" Politecnico di Torino - International

Optical fibers have recently attracted a noticeable interest for biomedical applications because they provide a minimally invasive method for in vivo sensing, imaging techniques, deep-tissue photodynamic therapy or optogenetics. The silica optical fibers are the most commonly used because they offer excellent optical properties, and they are readily available at a reasonable price. The fused silica is a biocompatible material, but it is not bioresorbable so it does not decompose in the body and the fibers must be ex-planted after in vivo use and their fragments can present a considerable risk to the patient when the fiber breaks. In contrast, optical fibers made of phosphate glasses can bring many benefits because such glasses exhibit good transparency in ultraviolet-visible and near-infrared regions, and their solubility in water can be tailored by changing the chemical composition. The bioresorbability and toxicity of phosphate glass-based optical fibers were tested in vivo on male laboratory rats for the first time. The fiber was spliced together with a standard graded-index multi-mode fiber pigtail and an optical probe for in vitro pH measurement was prepared by the immobilization of a fluorescent dye on the fiber tip by a sol-gel method to demonstrate applicability and compatibility of the fiber with common fiber optics.

References provided by Crossref.org

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