-
Something wrong with this record ?
Evaluation of antifungal effect and toxicity of xanthyletin and two bacterial metabolites against Thai isolates of Pythium insidiosum
K. Wittayapipath, C. Yenjai, C. Prariyachatigul, P. Hamal,
Language English Country Great Britain
Document type Journal Article, Research Support, Non-U.S. Gov't
NLK
Directory of Open Access Journals
from 2011
Free Medical Journals
from 2011
Nature Open Access
from 2011-12-01
PubMed Central
from 2011
Europe PubMed Central
from 2011
ProQuest Central
from 2011-01-01
Open Access Digital Library
from 2011-01-01
Open Access Digital Library
from 2011-01-01
Health & Medicine (ProQuest)
from 2011-01-01
ROAD: Directory of Open Access Scholarly Resources
from 2011
Springer Nature OA/Free Journals
from 2011-12-01
- MeSH
- Antifungal Agents pharmacology MeSH
- Antiparasitic Agents pharmacology MeSH
- Bacteria chemistry metabolism MeSH
- Cell Line MeSH
- Fibroblasts drug effects MeSH
- Hyphae drug effects ultrastructure MeSH
- Complex Mixtures MeSH
- Coumarins pharmacology MeSH
- Humans MeSH
- Microbial Sensitivity Tests MeSH
- Pythium drug effects MeSH
- Cell Survival drug effects MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
Pythiosis is a harmful disease caused by Pythium insidiosum, an aquatic oomycete. Therapeutic protocols based on antifungal drugs are often ineffective because the cytoplasmic membrane of P. insidiosum does not contain ergosterol. Therefore, the treatment of pythiosis is still challenging, particularly making use of natural products and secondary metabolites from bacteria. In this study, xanthyletin and substances obtained from Pseudomonas stutzeri ST1302 and Klebsiella pneumoniae ST2501 exhibited anti-P. insidiosum activity and, moreover, xanthyletin was non-toxic against human cell lines. The hyphae of P. insidiosum treated with these three substances exhibited lysis holes on a rough surface and release of anamorphic material. Therefore, xanthyletin could be considered a promising alternative agent for treating cutaneous pythiosis in the near future.
References provided by Crossref.org
- 000
- 00000naa a2200000 a 4500
- 001
- bmc20028387
- 003
- CZ-PrNML
- 005
- 20210114153718.0
- 007
- ta
- 008
- 210105s2020 xxk f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.1038/s41598-020-61271-0 $2 doi
- 035 __
- $a (PubMed)32161276
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a xxk
- 100 1_
- $a Wittayapipath, Kittiya $u Medical Science Program, Graduate School, Faculty of Associated Medical Sciences, Centre for Research and Development of Medical Diagnosis Laboratories, Khon Kaen University, Khon Kaen, Thailand.
- 245 10
- $a Evaluation of antifungal effect and toxicity of xanthyletin and two bacterial metabolites against Thai isolates of Pythium insidiosum / $c K. Wittayapipath, C. Yenjai, C. Prariyachatigul, P. Hamal,
- 520 9_
- $a Pythiosis is a harmful disease caused by Pythium insidiosum, an aquatic oomycete. Therapeutic protocols based on antifungal drugs are often ineffective because the cytoplasmic membrane of P. insidiosum does not contain ergosterol. Therefore, the treatment of pythiosis is still challenging, particularly making use of natural products and secondary metabolites from bacteria. In this study, xanthyletin and substances obtained from Pseudomonas stutzeri ST1302 and Klebsiella pneumoniae ST2501 exhibited anti-P. insidiosum activity and, moreover, xanthyletin was non-toxic against human cell lines. The hyphae of P. insidiosum treated with these three substances exhibited lysis holes on a rough surface and release of anamorphic material. Therefore, xanthyletin could be considered a promising alternative agent for treating cutaneous pythiosis in the near future.
- 650 _2
- $a antifungální látky $x farmakologie $7 D000935
- 650 _2
- $a antiparazitární látky $x farmakologie $7 D000977
- 650 _2
- $a Bacteria $x chemie $x metabolismus $7 D001419
- 650 _2
- $a buněčné linie $7 D002460
- 650 _2
- $a viabilita buněk $x účinky léků $7 D002470
- 650 _2
- $a komplexní směsi $7 D045424
- 650 _2
- $a kumariny $x farmakologie $7 D003374
- 650 _2
- $a fibroblasty $x účinky léků $7 D005347
- 650 _2
- $a lidé $7 D006801
- 650 _2
- $a hyfy $x účinky léků $x ultrastruktura $7 D025301
- 650 _2
- $a mikrobiální testy citlivosti $7 D008826
- 650 _2
- $a Pythium $x účinky léků $7 D011775
- 655 _2
- $a časopisecké články $7 D016428
- 655 _2
- $a práce podpořená grantem $7 D013485
- 700 1_
- $a Yenjai, Chavi $u Department of Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen, Thailand.
- 700 1_
- $a Prariyachatigul, Chularut $u Department of Clinical Microbiology, Faculty of Associated Medical Sciences, Centre for Research and Development of Medical Diagnosis Laboratories, Khon Kaen University, Khon Kaen, Thailand.
- 700 1_
- $a Hamal, Petr $u Department of Microbiology, Faculty of Medicine and Dentistry, Palacky University Olomouc, Hnevotinska 3, 77515, Olomouc, Czech Republic. petr.hamal@fnol.cz.
- 773 0_
- $w MED00182195 $t Scientific reports $x 2045-2322 $g Roč. 10, č. 1 (2020), s. 4495
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/32161276 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y a $z 0
- 990 __
- $a 20210105 $b ABA008
- 991 __
- $a 20210114153715 $b ABA008
- 999 __
- $a ok $b bmc $g 1608722 $s 1119567
- BAS __
- $a 3
- BAS __
- $a PreBMC
- BMC __
- $a 2020 $b 10 $c 1 $d 4495 $e 20200311 $i 2045-2322 $m Scientific reports $n Sci Rep $x MED00182195
- LZP __
- $a Pubmed-20210105
