Detail
Článek
FT
Medvik - BMČ
  • Je něco špatně v tomto záznamu ?

Experimental infections and co-infections with Leishmania braziliensis and Leishmania infantum in two sand fly species, Lutzomyia migonei and Lutzomyia longipalpis

J. Alexandre, J. Sadlova, T. Lestinova, B. Vojtkova, M. Jancarova, L. Podesvova, V. Yurchenko, F. Dantas-Torres, SP. Brandão-Filho, P. Volf,

. 2020 ; 10 (1) : 3566. [pub] 20200227

Jazyk angličtina Země Velká Británie

Typ dokumentu časopisecké články, práce podpořená grantem

Perzistentní odkaz   https://www.medvik.cz/link/bmc20028474

Leishmaniases are neglected tropical diseases and Leishmania (Leishmania) infantum and Leishmania (Viannia) braziliensis are the most important causative agents of leishmaniases in the New World. These two parasite species may co-circulate in a given endemic area but their interactions in the vector have not been studied yet. We conducted experimental infections using both single infections and co-infections to compare the development of L. (L.) infantum (OGVL/mCherry) and L. (V.) braziliensis (XB29/GFP) in Lutzomyia longipalpis and Lutzomyia migonei. Parasite labelling by different fluorescein proteins enabled studying interspecific competition and localization of different parasite species during co-infections. Both Leishmania species completed their life cycle, producing infective forms in both sand fly species studied. The same happens in the co infections, demonstrating that the two parasites conclude their development and do not compete with each other. However, infections produced by L. (L.) infantum reached higher rates and grew more vigorously, as compared to L. (V.) braziliensis. In late-stage infections, L. (L.) infantum was present in all midgut regions, showing typical suprapylarian type of development, whereas L. (V.) braziliensis was concentrated in the hindgut and the abdominal midgut (peripylarian development). We concluded that both Lu. migonei and Lu. longipalpis are equally susceptible vectors for L. (L.) infantum, in laboratory colonies. In relation to L. (V.) braziliensis, Lu. migonei appears to be more susceptible to this parasite than Lu. longipalpis.

000      
00000naa a2200000 a 4500
001      
bmc20028474
003      
CZ-PrNML
005      
20210114154000.0
007      
ta
008      
210105s2020 xxk f 000 0|eng||
009      
AR
024    7_
$a 10.1038/s41598-020-60600-7 $2 doi
035    __
$a (PubMed)32108151
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xxk
100    1_
$a Alexandre, Joanna $u Department of Immunology, Aggeu Magalhães Institute, Fiocruz, Pernambuco, Brazil.
245    10
$a Experimental infections and co-infections with Leishmania braziliensis and Leishmania infantum in two sand fly species, Lutzomyia migonei and Lutzomyia longipalpis / $c J. Alexandre, J. Sadlova, T. Lestinova, B. Vojtkova, M. Jancarova, L. Podesvova, V. Yurchenko, F. Dantas-Torres, SP. Brandão-Filho, P. Volf,
520    9_
$a Leishmaniases are neglected tropical diseases and Leishmania (Leishmania) infantum and Leishmania (Viannia) braziliensis are the most important causative agents of leishmaniases in the New World. These two parasite species may co-circulate in a given endemic area but their interactions in the vector have not been studied yet. We conducted experimental infections using both single infections and co-infections to compare the development of L. (L.) infantum (OGVL/mCherry) and L. (V.) braziliensis (XB29/GFP) in Lutzomyia longipalpis and Lutzomyia migonei. Parasite labelling by different fluorescein proteins enabled studying interspecific competition and localization of different parasite species during co-infections. Both Leishmania species completed their life cycle, producing infective forms in both sand fly species studied. The same happens in the co infections, demonstrating that the two parasites conclude their development and do not compete with each other. However, infections produced by L. (L.) infantum reached higher rates and grew more vigorously, as compared to L. (V.) braziliensis. In late-stage infections, L. (L.) infantum was present in all midgut regions, showing typical suprapylarian type of development, whereas L. (V.) braziliensis was concentrated in the hindgut and the abdominal midgut (peripylarian development). We concluded that both Lu. migonei and Lu. longipalpis are equally susceptible vectors for L. (L.) infantum, in laboratory colonies. In relation to L. (V.) braziliensis, Lu. migonei appears to be more susceptible to this parasite than Lu. longipalpis.
650    _2
$a zvířata $7 D000818
650    _2
$a trávicí systém $x parazitologie $7 D004064
650    _2
$a ženské pohlaví $7 D005260
650    _2
$a hmyz - vektory $x parazitologie $7 D007303
650    _2
$a Leishmania braziliensis $x růst a vývoj $x fyziologie $7 D007892
650    _2
$a Leishmania infantum $x růst a vývoj $x fyziologie $7 D018314
650    _2
$a stadia vývoje $7 D008018
650    _2
$a Psychodidae $x parazitologie $7 D011576
655    _2
$a časopisecké články $7 D016428
655    _2
$a práce podpořená grantem $7 D013485
700    1_
$a Sadlova, Jovana $u Department of Parasitology, Faculty of Science, Charles University, Prague, Czech Republic.
700    1_
$a Lestinova, Tereza $u Department of Parasitology, Faculty of Science, Charles University, Prague, Czech Republic.
700    1_
$a Vojtkova, Barbora $u Department of Parasitology, Faculty of Science, Charles University, Prague, Czech Republic.
700    1_
$a Jancarova, Magda $u Department of Parasitology, Faculty of Science, Charles University, Prague, Czech Republic.
700    1_
$a Podesvova, Lucie $u Life Science Research Centre, Faculty of Science, University of Ostrava, Ostrava, Czech Republic.
700    1_
$a Yurchenko, Vyacheslav $u Life Science Research Centre, Faculty of Science, University of Ostrava, Ostrava, Czech Republic. Martsinovsky Institute of Medical Parasitology, Tropical and Vector Borne Diseases, Sechenov University, Moscow, Russia.
700    1_
$a Dantas-Torres, Filipe $u Department of Immunology, Aggeu Magalhães Institute, Fiocruz, Pernambuco, Brazil.
700    1_
$a Brandão-Filho, Sinval P $u Department of Immunology, Aggeu Magalhães Institute, Fiocruz, Pernambuco, Brazil. sinval@cpqam.fiocruz.br.
700    1_
$a Volf, Petr $u Department of Parasitology, Faculty of Science, Charles University, Prague, Czech Republic.
773    0_
$w MED00182195 $t Scientific reports $x 2045-2322 $g Roč. 10, č. 1 (2020), s. 3566
856    41
$u https://pubmed.ncbi.nlm.nih.gov/32108151 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y a $z 0
990    __
$a 20210105 $b ABA008
991    __
$a 20210114153957 $b ABA008
999    __
$a ok $b bmc $g 1608809 $s 1119654
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2020 $b 10 $c 1 $d 3566 $e 20200227 $i 2045-2322 $m Scientific reports $n Sci Rep $x MED00182195
LZP    __
$a Pubmed-20210105

Najít záznam

Citační ukazatele

Možnosti archivace