-
Je něco špatně v tomto záznamu ?
Papillary renal cell carcinoma with prominent spindle cell stroma - tumor mimicking mixed epithelial and stromal tumor of the kidney: Clinicopathologic, morphologic, immunohistochemical and molecular genetic analysis of 6 cases
J. Rogala, F. Kojima, R. Alaghehbandan, A. Agaimy, P. Martinek, O. Ondic, M. Ulamec, M. Sperga, K. Michalova, K. Pivovarcikova, T. Pitra, M. Hora, I. Ferak, J. Marečková, M. Michal, O. Hes,
Jazyk angličtina Země Spojené státy americké
Typ dokumentu časopisecké články
- MeSH
- buňky stromatu patologie MeSH
- dospělí MeSH
- epitelové buňky patologie MeSH
- imunohistochemie MeSH
- karcinom z renálních buněk metabolismus patologie MeSH
- lidé středního věku MeSH
- lidé MeSH
- nádorové biomarkery metabolismus MeSH
- nádory ledvin metabolismus patologie MeSH
- papilární karcinom metabolismus patologie MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- variabilita počtu kopií segmentů DNA * MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- Publikační typ
- časopisecké články MeSH
Papillary renal cell carcinoma (PRCC) is currently a well-studied type of RCC. In addition to PRCC type 1, there are a number of other subtypes and variants of PRCCs which have been reported. We describe a series of 6 PRCCs with papillary, micropapillary and/or tubulopapillary architecture and prominent spindle cell stroma, resembling stroma in mixed epithelial and stromal tumor of the kidney (MESTK) or sarcomatoid RCC. Clinicopathologic, morphologic, immunohistochemical and molecular features were analyzed. All patients were males with an age range of 44-98 years (mean 65.3, median 65.5 years). Tumor size ranged from 2.4-11.4 cm (mean 5.8, median 4.5 cm). Follow-up data were available for 4 patients, ranging from 3 to 96 months (mean 42.75, median 36 months). Epithelial cells were mostly cylindrical with eosinophilic cytoplasm, showing nuclear grade 2 and 3 (ISUP/WHO). In all cases, loose to compact prominent stroma composed of spindle cells, without malignant mesenchymal heterologous elements was detected. No atypical mitoses were found, while typical mitoses were rare in both epithelial and stromal components. Epithelial cells were positive for CK7, AMACR, and vimentin in all cases, while negative for TFE3, HMB45, desmin, CD34, and actin. The stroma was positive for vimentin, actin and focally for CD34, while negative for CK7, AMACR, TFE3, HMB45, and desmin. Estrogen and progesterone receptors were completely negative. FH and SDHB expression was retained in all analyzable cases. Proliferative index was barely detectable in stromal component and low in epithelial component, ranging 0 to 5% positive stained cells/high power field. Copy number variation was variable with no distinct pattern. No mutations in CDKN2A, BAP1, MET were detected. PRCC with MESTK-like features is a distinct variant of PRCC mimicking MESTK. Our findings add to the body of literature on ever expanding variants of PRCCs. Both epithelial and stromal components lacked true Müllerian features, which was also proven by immunohistochemistry.
Department of Human Pathology Wakayama Medical University Wakayama Japan
Department of Pathology Agel Laboratory Novy Jicin Czech Republic
Department of Pathology Regional Specialist Hospital Wroclaw Poland
Department of Pathology Riga Stradin's University Riga Latvia
Department of Pathology University of Erlangen Erlangen Germany
Citace poskytuje Crossref.org
- 000
- 00000naa a2200000 a 4500
- 001
- bmc20028536
- 003
- CZ-PrNML
- 005
- 20210114154159.0
- 007
- ta
- 008
- 210105s2020 xxu f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.1016/j.anndiagpath.2019.151441 $2 doi
- 035 __
- $a (PubMed)31862520
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a xxu
- 100 1_
- $a Rogala, Joanna $u Department of Pathology, Charles University, Medical Faculty and Charles University Hospital Plzen, Czech Republic; Department of Pathology, Regional Specialist Hospital Wroclaw, Poland.
- 245 10
- $a Papillary renal cell carcinoma with prominent spindle cell stroma - tumor mimicking mixed epithelial and stromal tumor of the kidney: Clinicopathologic, morphologic, immunohistochemical and molecular genetic analysis of 6 cases / $c J. Rogala, F. Kojima, R. Alaghehbandan, A. Agaimy, P. Martinek, O. Ondic, M. Ulamec, M. Sperga, K. Michalova, K. Pivovarcikova, T. Pitra, M. Hora, I. Ferak, J. Marečková, M. Michal, O. Hes,
- 520 9_
- $a Papillary renal cell carcinoma (PRCC) is currently a well-studied type of RCC. In addition to PRCC type 1, there are a number of other subtypes and variants of PRCCs which have been reported. We describe a series of 6 PRCCs with papillary, micropapillary and/or tubulopapillary architecture and prominent spindle cell stroma, resembling stroma in mixed epithelial and stromal tumor of the kidney (MESTK) or sarcomatoid RCC. Clinicopathologic, morphologic, immunohistochemical and molecular features were analyzed. All patients were males with an age range of 44-98 years (mean 65.3, median 65.5 years). Tumor size ranged from 2.4-11.4 cm (mean 5.8, median 4.5 cm). Follow-up data were available for 4 patients, ranging from 3 to 96 months (mean 42.75, median 36 months). Epithelial cells were mostly cylindrical with eosinophilic cytoplasm, showing nuclear grade 2 and 3 (ISUP/WHO). In all cases, loose to compact prominent stroma composed of spindle cells, without malignant mesenchymal heterologous elements was detected. No atypical mitoses were found, while typical mitoses were rare in both epithelial and stromal components. Epithelial cells were positive for CK7, AMACR, and vimentin in all cases, while negative for TFE3, HMB45, desmin, CD34, and actin. The stroma was positive for vimentin, actin and focally for CD34, while negative for CK7, AMACR, TFE3, HMB45, and desmin. Estrogen and progesterone receptors were completely negative. FH and SDHB expression was retained in all analyzable cases. Proliferative index was barely detectable in stromal component and low in epithelial component, ranging 0 to 5% positive stained cells/high power field. Copy number variation was variable with no distinct pattern. No mutations in CDKN2A, BAP1, MET were detected. PRCC with MESTK-like features is a distinct variant of PRCC mimicking MESTK. Our findings add to the body of literature on ever expanding variants of PRCCs. Both epithelial and stromal components lacked true Müllerian features, which was also proven by immunohistochemistry.
- 650 _2
- $a dospělí $7 D000328
- 650 _2
- $a senioři $7 D000368
- 650 _2
- $a senioři nad 80 let $7 D000369
- 650 _2
- $a nádorové biomarkery $x metabolismus $7 D014408
- 650 _2
- $a papilární karcinom $x metabolismus $x patologie $7 D002291
- 650 _2
- $a karcinom z renálních buněk $x metabolismus $x patologie $7 D002292
- 650 12
- $a variabilita počtu kopií segmentů DNA $7 D056915
- 650 _2
- $a epitelové buňky $x patologie $7 D004847
- 650 _2
- $a lidé $7 D006801
- 650 _2
- $a imunohistochemie $7 D007150
- 650 _2
- $a nádory ledvin $x metabolismus $x patologie $7 D007680
- 650 _2
- $a mužské pohlaví $7 D008297
- 650 _2
- $a lidé středního věku $7 D008875
- 650 _2
- $a buňky stromatu $x patologie $7 D017154
- 655 _2
- $a časopisecké články $7 D016428
- 700 1_
- $a Kojima, Fumiyoshi $u Department of Human Pathology, Wakayama Medical University, Wakayama, Japan.
- 700 1_
- $a Alaghehbandan, Reza $u Department of Pathology, Faculty of Medicine, University of British Columbia, Royal Columbian Hospital, Vancouver, BC, Canada.
- 700 1_
- $a Agaimy, Abbas $u Department of Pathology, University of Erlangen, Erlangen, Germany.
- 700 1_
- $a Martinek, Petr $u Department of Pathology, Charles University, Medical Faculty and Charles University Hospital Plzen, Czech Republic.
- 700 1_
- $a Ondic, Ondrej $u Department of Pathology, Charles University, Medical Faculty and Charles University Hospital Plzen, Czech Republic.
- 700 1_
- $a Ulamec, Monika $u "Ljudevit Jurak" Pathology Department, Clinical Hospital Center "Sestre milosrdnice", Pathology Department, Medical University, Medical Faculty Zagreb, Croatia.
- 700 1_
- $a Sperga, Maris $u Department of Pathology, Riga Stradin's University, Riga, Latvia.
- 700 1_
- $a Michalova, Kvetoslava $u Department of Pathology, Charles University, Medical Faculty and Charles University Hospital Plzen, Czech Republic.
- 700 1_
- $a Pivovarcikova, Kristyna $u Department of Pathology, Charles University, Medical Faculty and Charles University Hospital Plzen, Czech Republic.
- 700 1_
- $a Pitra, Tomáš $u Department of Urology, Charles University, Medical Faculty and Charles University Hospital Plzen, Czech Republic.
- 700 1_
- $a Hora, Milan $u Department of Urology, Charles University, Medical Faculty and Charles University Hospital Plzen, Czech Republic.
- 700 1_
- $a Ferak, Ivan $u Department of Pathology, Agel Laboratory, Novy Jicin, Czech Republic.
- 700 1_
- $a Marečková, Jana $u Department of Pathology, Charles University, Medical Faculty and Charles University Hospital Plzen, Czech Republic.
- 700 1_
- $a Michal, Michal $u Department of Pathology, Charles University, Medical Faculty and Charles University Hospital Plzen, Czech Republic.
- 700 1_
- $a Hes, Ondrej $u Department of Pathology, Charles University, Medical Faculty and Charles University Hospital Plzen, Czech Republic. Electronic address: hes@medima.cz.
- 773 0_
- $w MED00166541 $t Annals of diagnostic pathology $x 1532-8198 $g Roč. 44, č. - (2020), s. 151441
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/31862520 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y a $z 0
- 990 __
- $a 20210105 $b ABA008
- 991 __
- $a 20210114154155 $b ABA008
- 999 __
- $a ok $b bmc $g 1608871 $s 1119716
- BAS __
- $a 3
- BAS __
- $a PreBMC
- BMC __
- $a 2020 $b 44 $c - $d 151441 $e 20191213 $i 1532-8198 $m Annals of diagnostic pathology $n Ann. diagn. pathol. $x MED00166541
- LZP __
- $a Pubmed-20210105
