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The Role of TLRs in Anti-cancer Immunity and Tumor Rejection

Z. Urban-Wojciuk, MM. Khan, BL. Oyler, R. Fåhraeus, N. Marek-Trzonkowska, A. Nita-Lazar, TR. Hupp, DR. Goodlett,

. 2019 ; 10 (-) : 2388. [pub] 20191022

Jazyk angličtina Země Švýcarsko

Typ dokumentu časopisecké články, Research Support, N.I.H., Extramural, práce podpořená grantem, přehledy

Perzistentní odkaz   https://www.medvik.cz/link/bmc20028784

Grantová podpora
1R01AI123820-01 NIAID NIH HHS - United States

In recent years, a lot of scientific interest has focused on cancer immunotherapy. Although chronic inflammation has been described as one of the hallmarks of cancer, acute inflammation can actually trigger the immune system to fight diseases, including cancer. Toll-like receptor (TLR) ligands have long been used as adjuvants for traditional vaccines and it seems they may also play a role enhancing efficiency of tumor immunotherapy. The aim of this perspective is to discuss the effects of TLR stimulation in cancer, expression of various TLRs in different types of tumors, and finally the role of TLRs in anti-cancer immunity and tumor rejection.

Citace poskytuje Crossref.org

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$a Khan, Mohd M $u Laboratory of Immune System Biology (LISB), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, United States. University of Maryland School of Medicine, Baltimore, MD, United States.
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