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The Role of TLRs in Anti-cancer Immunity and Tumor Rejection

Z. Urban-Wojciuk, MM. Khan, BL. Oyler, R. Fåhraeus, N. Marek-Trzonkowska, A. Nita-Lazar, TR. Hupp, DR. Goodlett,

. 2019 ; 10 (-) : 2388. [pub] 20191022

Language English Country Switzerland

Document type Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Review

Persistent link   https://www.medvik.cz/link/bmc20028784

Grant support
1R01AI123820-01 NIAID NIH HHS - United States

In recent years, a lot of scientific interest has focused on cancer immunotherapy. Although chronic inflammation has been described as one of the hallmarks of cancer, acute inflammation can actually trigger the immune system to fight diseases, including cancer. Toll-like receptor (TLR) ligands have long been used as adjuvants for traditional vaccines and it seems they may also play a role enhancing efficiency of tumor immunotherapy. The aim of this perspective is to discuss the effects of TLR stimulation in cancer, expression of various TLRs in different types of tumors, and finally the role of TLRs in anti-cancer immunity and tumor rejection.

References provided by Crossref.org

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$a Khan, Mohd M $u Laboratory of Immune System Biology (LISB), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, United States. University of Maryland School of Medicine, Baltimore, MD, United States.
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$a Oyler, Benjamin L $u University of Maryland School of Medicine, Baltimore, MD, United States.
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$a Fåhraeus, Robin $u International Centre for Cancer Vaccine Science (ICCVS), University of Gdaǹsk, Gdaǹsk, Poland. Department of Medical Biosciences, Umeå University, Umeå, Sweden. Université Paris 7, INSERM, UMR 1162, Paris, France. Regional Centre for Applied Molecular Oncology, Masaryk Memorial Cancer Institute, Brno, Czechia.
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$a Marek-Trzonkowska, Natalia $u International Centre for Cancer Vaccine Science (ICCVS), University of Gdaǹsk, Gdaǹsk, Poland. Laboratory of Immunoregulation and Cellular Therapies, Department of Family Medicine, Medical University of Gdaǹsk, Gdaǹsk, Poland.
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$a Goodlett, David R $u International Centre for Cancer Vaccine Science (ICCVS), University of Gdaǹsk, Gdaǹsk, Poland. Department of Microbial Pathogenesis, University of Maryland School of Dentistry, Baltimore, MD, United States.
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