-
Je něco špatně v tomto záznamu ?
Study of the latent phase of radiation-induced lung injury
Anna Lierová, Marcela Jeličová, Jaroslav Pejchal, Zuzana Šinkorová
Jazyk angličtina Země Česko
Typ dokumentu práce podpořená grantem
- MeSH
- cytokiny analýza krev účinky záření MeSH
- lymfocyty účinky záření MeSH
- modely nemocí na zvířatech MeSH
- myši MeSH
- poškození plic * patofyziologie MeSH
- radiační poranění * patofyziologie MeSH
- zvířata MeSH
- Check Tag
- myši MeSH
- zvířata MeSH
- Publikační typ
- práce podpořená grantem MeSH
Early changes after radiation exposure may serve as predictors as well as targets for alleviation of radiation-induced injury in the lung. The aim of our study was to examine alterations on the cell and tissue levels in the lung and blood changes of immunological and cytokines profiles induced by ionizing radiation (IR) during the first month after irradiation in the mice experimental model. Female C57BL/6 mice were total body irradiated (TBI) by 8 Gy. Lung tissue samples and blood and were collected 4, 8 and 24 h, 7, 21 and 30 d after TBI. We measured absolute cell counts, cell populations and cytokines profile in the blood and evaluated histopathological analysis in the lung, immunophenotypization of the main lung cell populations and cytokine profiles. In blood, the acute radiation syndrome developed with recovery being observed at 21-30 d, observed by hematological markers. In the lung tissue, a biphasic response occurred. At first, a significant decreased of lymphocytes, resident tissues macrophages and air/tissue ratio associated with increased neutrophils was observed at 8 - 24 h. Subsequently, increase in infiltrating CD4+ T-lymphocytes, neutrophils and resident tissues macrophages and decreased airiness were measured 21 and 30 d after TBI. In summary, our study describes the mechanisms that lung tissue enables to cope with non-lethal injury.
- 000
- 00000naa a2200000 a 4500
- 001
- bmc21006210
- 003
- CZ-PrNML
- 005
- 20210511155509.0
- 007
- ta
- 008
- 210302s2020 xr d f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.31482/mmsl.2020.015 $2 doi
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a xr
- 100 1_
- $a Lierová, Anna $7 xx0252800 $u Department of Radiobiology, Faculty of Military Health Sciences, University of Defence, Hradec Kralove,Czech Republic
- 245 10
- $a Study of the latent phase of radiation-induced lung injury / $c Anna Lierová, Marcela Jeličová, Jaroslav Pejchal, Zuzana Šinkorová
- 520 9_
- $a Early changes after radiation exposure may serve as predictors as well as targets for alleviation of radiation-induced injury in the lung. The aim of our study was to examine alterations on the cell and tissue levels in the lung and blood changes of immunological and cytokines profiles induced by ionizing radiation (IR) during the first month after irradiation in the mice experimental model. Female C57BL/6 mice were total body irradiated (TBI) by 8 Gy. Lung tissue samples and blood and were collected 4, 8 and 24 h, 7, 21 and 30 d after TBI. We measured absolute cell counts, cell populations and cytokines profile in the blood and evaluated histopathological analysis in the lung, immunophenotypization of the main lung cell populations and cytokine profiles. In blood, the acute radiation syndrome developed with recovery being observed at 21-30 d, observed by hematological markers. In the lung tissue, a biphasic response occurred. At first, a significant decreased of lymphocytes, resident tissues macrophages and air/tissue ratio associated with increased neutrophils was observed at 8 - 24 h. Subsequently, increase in infiltrating CD4+ T-lymphocytes, neutrophils and resident tissues macrophages and decreased airiness were measured 21 and 30 d after TBI. In summary, our study describes the mechanisms that lung tissue enables to cope with non-lethal injury.
- 650 12
- $a radiační poranění $x patofyziologie $7 D011832
- 650 12
- $a poškození plic $x patofyziologie $7 D055370
- 650 _2
- $a lymfocyty $x účinky záření $7 D008214
- 650 _2
- $a cytokiny $x analýza $x krev $x účinky záření $7 D016207
- 650 _2
- $a myši $7 D051379
- 650 _2
- $a zvířata $7 D000818
- 650 _2
- $a modely nemocí na zvířatech $7 D004195
- 655 _2
- $a práce podpořená grantem $7 D013485
- 700 1_
- $a Jeličová, Marcela $7 xx0252799 $u Department of Toxicology and Military Pharmacy, Faculty of Military Health Sciences, University of Defence,Hradec Kralove, Czech Republic
- 700 1_
- $a Pejchal, Jaroslav $7 xx0102560 $u Department of Radiobiology, Faculty of Military Health Sciences, University of Defence, Hradec Kralove,Czech Republic
- 700 1_
- $a Šinkorová, Jana $7 _AN028601 $u Department of Radiobiology, Faculty of Military Health Sciences, University of Defence, Hradec Kralove,Czech Republic
- 773 0_
- $t Vojenské zdravotnické listy $x 0372-7025 $g Roč. 89, č. 4 (2020), s. 190-199 $w MED00011116
- 856 41
- $u https://mmsl.cz/artkey/mms-202004-0002_study-of-the-latent-phase-of-radiation-induced-lung-injury.php $y plný text volně přístupný
- 910 __
- $a ABA008 $b A 3 $c 1073 $y p $z 0
- 990 __
- $a 20210302 $b ABA008
- 991 __
- $a 20210511155507 $b ABA008
- 999 __
- $a ok $b bmc $g 1635009 $s 1126543
- BAS __
- $a 3
- BAS __
- $a PreBMC
- BMC __
- $a 2020 $b 89 $c 4 $d 190-199 $e 20201204 $i 0372-7025 $m Vojenské zdravotnické listy $x MED00011116
- LZP __
- $c NLK109 $d 20210511 $b NLK138 $a Actavia-MED00011116-20210302