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Molecular Assessment of Kidney Allografts: Are We Closer to a Daily Routine
A. Trailin, P. Hruba, O. Viklicky
Language English Country Czech Republic
Document type Journal Article, Review
NLK
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Free Medical Journals
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PubMed Central
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ProQuest Central
from 2005-01-01
Medline Complete (EBSCOhost)
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Nursing & Allied Health Database (ProQuest)
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- MeSH
- Allografts metabolism MeSH
- Molecular Diagnostic Techniques methods trends MeSH
- Humans MeSH
- Graft Survival physiology MeSH
- Graft Rejection diagnosis genetics metabolism MeSH
- Transcriptome physiology MeSH
- Kidney Transplantation adverse effects trends MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Review MeSH
Kidney allograft pathology assessment has been traditionally based on clinical and histological criteria. Despite improvements in Banff histological classification, the diagnostics in particular cases is problematic reflecting a complex pathogenesis of graft injuries. With the advent of molecular techniques, polymerase-chain reaction, oligo- and microarray technologies allowed to study molecular phenotypes of graft injuries, especially acute and chronic rejections. Moreover, development of the molecular microscope diagnostic system (MMDx) to assess kidney graft biopsies, represents the first clinical application of a microarray-based method in transplantation. Whether MMDx may replace conventional pathology is the subject of ongoing research, however this platform is particularly useful in complex histological findings and may help clinicians to guide the therapy.
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Literatura
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