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Drug dosing in cancer patients with decreased kidney function: A practical approach

B. Sprangers, G. Sandhu, MH. Rosner, P. Tesarova, WM. Stadler, J. Malyszko

. 2021 ; 93 (-) : 102139. [pub] 20201216

Jazyk angličtina Země Nizozemsko

Typ dokumentu časopisecké články, přehledy

Perzistentní odkaz   https://www.medvik.cz/link/bmc21011519

Correct drug dosing of anticancer agents is essential to obtain optimal outcomes. Overdosing will result in increased toxicity, treatment interruption and possible cessation of anticancer treatment. Underdosing may result in suboptimal anti-cancer effects and may increase the risk of cancer-related mortality. As it is practical nor feasible to perform therapeutic drug monitoring for all anti-cancer drugs, kidney function is used to guide drug dosing for those drugs whose primary mode of excretion is through the kidney. However, it is not well-established what method should be utilized to measure or estimate kidney function and the choice of method does influence treatment decisions regarding eligibility for anti-cancer drugs and their dose. In this review, we will provide an overview regarding the importance of drug dosing, the preferred method to determine kidney function and a practical approach to drug dosing of anticancer drugs.

Citace poskytuje Crossref.org

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$a Sprangers, Ben $u Department of Microbiology, Immunology and Transplantation, Laboratory of Molecular Immunology, Rega Institute for Medical Research, KU Leuven and Division of Nephrology, University Hospitals Leuven, Both in Leuven, Belgium. Electronic address: ben.sprangers@uzleuven.be
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$a Correct drug dosing of anticancer agents is essential to obtain optimal outcomes. Overdosing will result in increased toxicity, treatment interruption and possible cessation of anticancer treatment. Underdosing may result in suboptimal anti-cancer effects and may increase the risk of cancer-related mortality. As it is practical nor feasible to perform therapeutic drug monitoring for all anti-cancer drugs, kidney function is used to guide drug dosing for those drugs whose primary mode of excretion is through the kidney. However, it is not well-established what method should be utilized to measure or estimate kidney function and the choice of method does influence treatment decisions regarding eligibility for anti-cancer drugs and their dose. In this review, we will provide an overview regarding the importance of drug dosing, the preferred method to determine kidney function and a practical approach to drug dosing of anticancer drugs.
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$a Sandhu, Geeta $u eviQ, Cancer Institute NSW, Alexandria NSW, Australia
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$a Rosner, Mitchel H $u Division of Nephrology, University of Virginia Health System, Charlottesville, VA, USA
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$a Tesarova, Petra $u Department of Oncology, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic
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$a Stadler, Walter M $u Section of Hematology/Oncology, University of Chicago, IL, USA
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