• Je něco špatně v tomto záznamu ?

A frog with three sex chromosomes that co-mingle together in nature: Xenopus tropicalis has a degenerate W and a Y that evolved from a Z chromosome

BLS. Furman, CMS. Cauret, M. Knytl, XY. Song, T. Premachandra, C. Ofori-Boateng, DC. Jordan, ME. Horb, BJ. Evans

. 2020 ; 16 (11) : e1009121. [pub] 20201109

Jazyk angličtina Země Spojené státy americké

Typ dokumentu časopisecké články, Research Support, N.I.H., Extramural, práce podpořená grantem

Perzistentní odkaz   https://www.medvik.cz/link/bmc21011896

Grantová podpora
R01 HD084409 NICHD NIH HHS - United States
P40 OD010997 NIH HHS - United States

In many species, sexual differentiation is a vital prelude to reproduction, and disruption of this process can have severe fitness effects, including sterility. It is thus interesting that genetic systems governing sexual differentiation vary among-and even within-species. To understand these systems more, we investigated a rare example of a frog with three sex chromosomes: the Western clawed frog, Xenopus tropicalis. We demonstrate that natural populations from the western and eastern edges of Ghana have a young Y chromosome, and that a male-determining factor on this Y chromosome is in a very similar genomic location as a previously known female-determining factor on the W chromosome. Nucleotide polymorphism of expressed transcripts suggests genetic degeneration on the W chromosome, emergence of a new Y chromosome from an ancestral Z chromosome, and natural co-mingling of the W, Z, and Y chromosomes in the same population. Compared to the rest of the genome, a small sex-associated portion of the sex chromosomes has a 50-fold enrichment of transcripts with male-biased expression during early gonadal differentiation. Additionally, X. tropicalis has sex-differences in the rates and genomic locations of recombination events during gametogenesis that are similar to at least two other Xenopus species, which suggests that sex differences in recombination are genus-wide. These findings are consistent with theoretical expectations associated with recombination suppression on sex chromosomes, demonstrate that several characteristics of old and established sex chromosomes (e.g., nucleotide divergence, sex biased expression) can arise well before sex chromosomes become cytogenetically distinguished, and show how these characteristics can have lingering consequences that are carried forward through sex chromosome turnovers.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc21011896
003      
CZ-PrNML
005      
20210507104153.0
007      
ta
008      
210420s2020 xxu f 000 0|eng||
009      
AR
024    7_
$a 10.1371/journal.pgen.1009121 $2 doi
035    __
$a (PubMed)33166278
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xxu
100    1_
$a Furman, Benjamin L S $u Department of Biology, McMaster University, 1280 Main Street West, Hamilton, Ontario, L8S 4K1, Canada $u Department of Zoology, University of British Columbia, 6270 University Blvd Vancouver, British Columbia, V6T 1Z4 Canada
245    12
$a A frog with three sex chromosomes that co-mingle together in nature: Xenopus tropicalis has a degenerate W and a Y that evolved from a Z chromosome / $c BLS. Furman, CMS. Cauret, M. Knytl, XY. Song, T. Premachandra, C. Ofori-Boateng, DC. Jordan, ME. Horb, BJ. Evans
520    9_
$a In many species, sexual differentiation is a vital prelude to reproduction, and disruption of this process can have severe fitness effects, including sterility. It is thus interesting that genetic systems governing sexual differentiation vary among-and even within-species. To understand these systems more, we investigated a rare example of a frog with three sex chromosomes: the Western clawed frog, Xenopus tropicalis. We demonstrate that natural populations from the western and eastern edges of Ghana have a young Y chromosome, and that a male-determining factor on this Y chromosome is in a very similar genomic location as a previously known female-determining factor on the W chromosome. Nucleotide polymorphism of expressed transcripts suggests genetic degeneration on the W chromosome, emergence of a new Y chromosome from an ancestral Z chromosome, and natural co-mingling of the W, Z, and Y chromosomes in the same population. Compared to the rest of the genome, a small sex-associated portion of the sex chromosomes has a 50-fold enrichment of transcripts with male-biased expression during early gonadal differentiation. Additionally, X. tropicalis has sex-differences in the rates and genomic locations of recombination events during gametogenesis that are similar to at least two other Xenopus species, which suggests that sex differences in recombination are genus-wide. These findings are consistent with theoretical expectations associated with recombination suppression on sex chromosomes, demonstrate that several characteristics of old and established sex chromosomes (e.g., nucleotide divergence, sex biased expression) can arise well before sex chromosomes become cytogenetically distinguished, and show how these characteristics can have lingering consequences that are carried forward through sex chromosome turnovers.
650    _2
$a zvířata $7 D000818
650    _2
$a ženské pohlaví $7 D005260
650    _2
$a genetická zdatnost $7 D056084
650    _2
$a mužské pohlaví $7 D008297
650    _2
$a rekombinace genetická $7 D011995
650    _2
$a pohlavní chromozomy $x genetika $7 D012730
650    _2
$a procesy určující pohlaví $x genetika $7 D019849
650    _2
$a sexuální diferenciace $x genetika $7 D012733
650    _2
$a Xenopus $x genetika $7 D014981
651    _2
$a Ghana $7 D005869
655    _2
$a časopisecké články $7 D016428
655    _2
$a Research Support, N.I.H., Extramural $7 D052061
655    _2
$a práce podpořená grantem $7 D013485
700    1_
$a Cauret, Caroline M S $u Department of Biology, McMaster University, 1280 Main Street West, Hamilton, Ontario, L8S 4K1, Canada
700    1_
$a Knytl, Martin $u Department of Biology, McMaster University, 1280 Main Street West, Hamilton, Ontario, L8S 4K1, Canada $u Department of Cell Biology, Charles University, 7 Vinicna Street, Prague, 12843, Czech Republic
700    1_
$a Song, Xue-Ying $u Department of Biology, McMaster University, 1280 Main Street West, Hamilton, Ontario, L8S 4K1, Canada
700    1_
$a Premachandra, Tharindu $u Department of Biology, McMaster University, 1280 Main Street West, Hamilton, Ontario, L8S 4K1, Canada
700    1_
$a Ofori-Boateng, Caleb $u CSIR-Forestry Research Institute of Ghana, Kumasi, Ghana
700    1_
$a Jordan, Danielle C $u Eugene Bell Center for Regenerative Biology and Tissue Engineering and National Xenopus Resource, Marine Biological Laboratory, 7 MBL St, Woods Hole, MA 02543 USA
700    1_
$a Horb, Marko E $u Eugene Bell Center for Regenerative Biology and Tissue Engineering and National Xenopus Resource, Marine Biological Laboratory, 7 MBL St, Woods Hole, MA 02543 USA
700    1_
$a Evans, Ben J $u Department of Biology, McMaster University, 1280 Main Street West, Hamilton, Ontario, L8S 4K1, Canada
773    0_
$w MED00008920 $t PLoS genetics $x 1553-7404 $g Roč. 16, č. 11 (2020), s. e1009121
856    41
$u https://pubmed.ncbi.nlm.nih.gov/33166278 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y p $z 0
990    __
$a 20210420 $b ABA008
991    __
$a 20210507104151 $b ABA008
999    __
$a ok $b bmc $g 1650304 $s 1132275
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2020 $b 16 $c 11 $d e1009121 $e 20201109 $i 1553-7404 $m PLoS genetics $n PLoS Genet $x MED00008920
GRA    __
$a R01 HD084409 $p NICHD NIH HHS $2 United States
GRA    __
$a P40 OD010997 $p NIH HHS $2 United States
LZP    __
$a Pubmed-20210420

Najít záznam

Citační ukazatele

Možnosti archivace