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Iron Complexes of Flavonoids-Antioxidant Capacity and Beyond

Z. Kejík, R. Kaplánek, M. Masařík, P. Babula, A. Matkowski, P. Filipenský, K. Veselá, J. Gburek, D. Sýkora, P. Martásek, M. Jakubek

. 2021 ; 22 (2) : . [pub] 20210111

Jazyk angličtina Země Švýcarsko

Typ dokumentu časopisecké články, přehledy

Perzistentní odkaz   https://www.medvik.cz/link/bmc21019459

Grantová podpora
BIOCEV-FAR Ministry of Education, Youth and Sports of the Czech Republic
LQ1604 Ministry of Education, Youth and Sports of the Czech Republic
LM2018133 Ministry of Education, Youth and Sports of the Czech Republic
SVV260521 Charles University in Prague
UNCE 204064 Charles University in Prague
Progress Q26/LF1 Charles University in Prague
Q27/LF1 Charles University in Prague
RVO-VFN-64165/2012 Ministry of Health of the Czech Republic
FV20572 Ministry of Industry and Trade of Czech Republic
TN01000013 Technology Agency of the Czech Republic
FW02020128 Technology Agency of the Czech Republic
CZ.02.1.01/0.0/0.0/16_019/0000785 Operational Programme Research, Development and Education

Flavonoids are common plant natural products able to suppress ROS-related damage and alleviate oxidative stress. One of key mechanisms, involved in this phenomenon is chelation of transition metal ions. From a physiological perspective, iron is the most significant transition metal, because of its abundance in living organisms and ubiquitous involvement in redox processes. The chemical, pharmaceutical, and biological properties of flavonoids can be significantly affected by their interaction with transition metal ions, mainly iron. In this review, we explain the interaction of various flavonoid structures with Fe(II) and Fe(III) ions and critically discuss the influence of chelated ions on the flavonoid biochemical properties. In addition, specific biological effects of their iron metallocomplexes, such as the inhibition of iron-containing enzymes, have been included in this review.

Citace poskytuje Crossref.org

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