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Structural Alterations in Deep Brain Structures in Type 1 Diabetes

P. Filip, A. Canna, A. Moheet, P. Bednarik, H. Grohn, X. Li, AF. Kumar, E. Olawsky, LE. Eberly, ER. Seaquist, S. Mangia

. 2020 ; 69 (11) : 2458-2466. [pub] 20200824

Jazyk angličtina Země Spojené státy americké

Typ dokumentu časopisecké články, Research Support, N.I.H., Extramural, práce podpořená grantem

Perzistentní odkaz   https://www.medvik.cz/link/bmc21011917

Grantová podpora
P41 EB015894 NIBIB NIH HHS - United States
UL1 TR002494 NCATS NIH HHS - United States
R01 DK099137 NIDDK NIH HHS - United States
P30 NS076408 NINDS NIH HHS - United States
KL2 TR002492 NCATS NIH HHS - United States
R56 DK099137 NIDDK NIH HHS - United States
T32 DK007203 NIDDK NIH HHS - United States
UL1 TR000114 NCATS NIH HHS - United States
KL2 TR000113 NCATS NIH HHS - United States

Even though well known in type 2 diabetes, the existence of brain changes in type 1 diabetes (T1D) and both their neuroanatomical and clinical features are less well characterized. To fill the void in the current understanding of this disease, we sought to determine the possible neural correlate in long-duration T1D at several levels, including macrostructural, microstructural cerebral damage, and blood flow alterations. In this cross-sectional study, we compared a cohort of 61 patients with T1D with an average disease duration of 21 years with 54 well-matched control subjects without diabetes in a multimodal MRI protocol providing macrostructural metrics (cortical thickness and structural volumes), microstructural measures (T1-weighted/T2-weighted [T1w/T2w] ratio as a marker of myelin content, inflammation, and edema), and cerebral blood flow. Patients with T1D had higher T1w/T2w ratios in the right parahippocampal gyrus, the executive part of both putamina, both thalami, and the cerebellum. These alterations were reflected in lower putaminal and thalamic volume bilaterally. No cerebral blood flow differences between groups were found in any of these structures, suggesting nonvascular etiologies of these changes. Our findings implicate a marked nonvascular disruption in T1D of several essential neural nodes engaged in both cognitive and motor processing.

Citace poskytuje Crossref.org

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$a Filip, Pavel $u Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN ; Department of Neurology, Charles University, First Faculty of Medicine and General University Hospital, Prague, Czech Republic ; First Department of Neurology, Faculty of Medicine, Masaryk University and University Hospital of St. Anne, Brno, Czech Republic
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$a Moheet, Amir $u Department of Medicine, University of Minnesota, Minneapolis, MN
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