• Something wrong with this record ?

High frequency oscillations in epileptic and non-epileptic human hippocampus during a cognitive task

M. Pail, J. Cimbálník, R. Roman, P. Daniel, DJ. Shaw, J. Chrastina, M. Brázdil

. 2020 ; 10 (1) : 18147. [pub] 20201023

Language English Country Great Britain

Document type Journal Article, Observational Study, Research Support, Non-U.S. Gov't

Persistent link   https://www.medvik.cz/link/bmc21011997

Hippocampal high-frequency electrographic activity (HFOs) represents one of the major discoveries not only in epilepsy research but also in cognitive science over the past few decades. A fundamental challenge, however, has been the fact that physiological HFOs associated with normal brain function overlap in frequency with pathological HFOs. We investigated the impact of a cognitive task on HFOs with the aim of improving differentiation between epileptic and non-epileptic hippocampi in humans. Hippocampal activity was recorded with depth electrodes in 15 patients with focal epilepsy during a resting period and subsequently during a cognitive task. HFOs in ripple and fast ripple frequency ranges were evaluated in both conditions, and their rate, spectral entropy, relative amplitude and duration were compared in epileptic and non-epileptic hippocampi. The similarity of HFOs properties recorded at rest in epileptic and non-epileptic hippocampi suggests that they cannot be used alone to distinguish between hippocampi. However, both ripples and fast ripples were observed with higher rates, higher relative amplitudes and longer durations at rest as well as during a cognitive task in epileptic compared with non-epileptic hippocampi. Moreover, during a cognitive task, significant reductions of HFOs rates were found in epileptic hippocampi. These reductions were not observed in non-epileptic hippocampi. Our results indicate that although both hippocampi generate HFOs with similar features that probably reflect non-pathological phenomena, it is possible to differentiate between epileptic and non-epileptic hippocampi using a simple odd-ball task.

References provided by Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc21011997
003      
CZ-PrNML
005      
20210924104222.0
007      
ta
008      
210420s2020 xxk f 000 0|eng||
009      
AR
024    7_
$a 10.1038/s41598-020-74306-3 $2 doi
035    __
$a (PubMed)33097749
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xxk
100    1_
$a Pail, Martin $u First Department of Neurology, Brno Epilepsy Center (Full member of the ERN EpiCARE), St. Anne's University Hospital and Medical Faculty of Masaryk University, Pekařská 53, Brno, 65691, Czech Republic. martin.pail@fnusa.cz $7 xx0264305
245    10
$a High frequency oscillations in epileptic and non-epileptic human hippocampus during a cognitive task / $c M. Pail, J. Cimbálník, R. Roman, P. Daniel, DJ. Shaw, J. Chrastina, M. Brázdil
520    9_
$a Hippocampal high-frequency electrographic activity (HFOs) represents one of the major discoveries not only in epilepsy research but also in cognitive science over the past few decades. A fundamental challenge, however, has been the fact that physiological HFOs associated with normal brain function overlap in frequency with pathological HFOs. We investigated the impact of a cognitive task on HFOs with the aim of improving differentiation between epileptic and non-epileptic hippocampi in humans. Hippocampal activity was recorded with depth electrodes in 15 patients with focal epilepsy during a resting period and subsequently during a cognitive task. HFOs in ripple and fast ripple frequency ranges were evaluated in both conditions, and their rate, spectral entropy, relative amplitude and duration were compared in epileptic and non-epileptic hippocampi. The similarity of HFOs properties recorded at rest in epileptic and non-epileptic hippocampi suggests that they cannot be used alone to distinguish between hippocampi. However, both ripples and fast ripples were observed with higher rates, higher relative amplitudes and longer durations at rest as well as during a cognitive task in epileptic compared with non-epileptic hippocampi. Moreover, during a cognitive task, significant reductions of HFOs rates were found in epileptic hippocampi. These reductions were not observed in non-epileptic hippocampi. Our results indicate that although both hippocampi generate HFOs with similar features that probably reflect non-pathological phenomena, it is possible to differentiate between epileptic and non-epileptic hippocampi using a simple odd-ball task.
650    _2
$a dospělí $7 D000328
650    _2
$a mozkové vlny $x fyziologie $7 D058256
650    _2
$a kognice $x fyziologie $7 D003071
650    _2
$a refrakterní epilepsie $x diagnóza $x patofyziologie $x terapie $7 D000069279
650    _2
$a implantované elektrody $7 D004567
650    _2
$a elektroencefalografie $x přístrojové vybavení $7 D004569
650    _2
$a epilepsie temporálního laloku $x diagnóza $x patofyziologie $x terapie $7 D004833
650    _2
$a ženské pohlaví $7 D005260
650    _2
$a hipokampus $x patofyziologie $7 D006624
650    _2
$a lidé $7 D006801
650    _2
$a mužské pohlaví $7 D008297
650    _2
$a lidé středního věku $7 D008875
650    _2
$a neuropsychologické testy $7 D009483
650    _2
$a mladý dospělý $7 D055815
655    _2
$a časopisecké články $7 D016428
655    _2
$a pozorovací studie $7 D064888
655    _2
$a práce podpořená grantem $7 D013485
700    1_
$a Cimbálník, Jan $u International Clinical Research Center, St. Anne's University Hospital, Brno, Czech Republic
700    1_
$a Roman, Robert $u First Department of Neurology, Brno Epilepsy Center (Full member of the ERN EpiCARE), St. Anne's University Hospital and Medical Faculty of Masaryk University, Pekařská 53, Brno, 65691, Czech Republic $u CEITEC - Central European Institute of Technology, Masaryk University, Brno, Czech Republic
700    1_
$a Daniel, Pavel $u First Department of Neurology, Brno Epilepsy Center (Full member of the ERN EpiCARE), St. Anne's University Hospital and Medical Faculty of Masaryk University, Pekařská 53, Brno, 65691, Czech Republic $u CEITEC - Central European Institute of Technology, Masaryk University, Brno, Czech Republic
700    1_
$a Shaw, Daniel J $u CEITEC - Central European Institute of Technology, Masaryk University, Brno, Czech Republic $u School of Life and Health Sciences, Aston University, Birmingham, UK
700    1_
$a Chrastina, Jan $u Department of Neurosurgery, Brno Epilepsy Center, St. Anne's University Hospital and Medical Faculty of Masaryk University, Brno, Czech Republic
700    1_
$a Brázdil, Milan $u First Department of Neurology, Brno Epilepsy Center (Full member of the ERN EpiCARE), St. Anne's University Hospital and Medical Faculty of Masaryk University, Pekařská 53, Brno, 65691, Czech Republic $u CEITEC - Central European Institute of Technology, Masaryk University, Brno, Czech Republic
773    0_
$w MED00182195 $t Scientific reports $x 2045-2322 $g Roč. 10, č. 1 (2020), s. 18147
856    41
$u https://pubmed.ncbi.nlm.nih.gov/33097749 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y p $z 0
990    __
$a 20210420 $b ABA008
991    __
$a 20210924104220 $b ABA008
999    __
$a ok $b bmc $g 1650388 $s 1132376
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2020 $b 10 $c 1 $d 18147 $e 20201023 $i 2045-2322 $m Scientific reports $n Sci Rep $x MED00182195
LZP    __
$a Pubmed-20210420

Find record

Citation metrics

Archiving options