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Giant cell aortitis
P. Handlos, M. Uvíra, M. Dokoupil, O. Klabal, K. Handlosová
Jazyk angličtina Země Spojené státy americké
Typ dokumentu kazuistiky, časopisecké články
Grantová podpora
RVO - FNOs/2017.
Ministerstvo Zdravotnictví Ceské Republiky - International
- MeSH
- aneurysma hrudní aorty patologie MeSH
- aorta patologie MeSH
- aortální insuficience patologie MeSH
- aterosklerotický plát patologie MeSH
- dospělí MeSH
- dysfunkce levé srdeční komory etiologie MeSH
- fibróza patologie MeSH
- hyperplazie MeSH
- lidé MeSH
- makrofágy patologie MeSH
- myokard patologie MeSH
- nemoci koronárních tepen patologie MeSH
- obrovskobuněčná arteritida patologie MeSH
- tunica media patologie MeSH
- Check Tag
- dospělí MeSH
- lidé MeSH
- mužské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- kazuistiky MeSH
Inflammatory aortic diseases are broadly classified into three categories according to the degree of inflammation: atherosclerosis, atherosclerosis with excessive inflammation, and aortitis/periaortitis. This paper presents a case of a 39-year old man with aneurysmal dilatation of thoracic aorta and aortic valve insufficiency. The aortic wall showed thickening and wrinkled "tree bark" appearance as well as apparent scarring of the intima. Histological examination revealed intimal hyperplasia, a granulomatous/giant cell pattern in the inner tunica media, a few epithelioid macrophages, abundant chronic lymphoplasmacytic and histiocytic inflammation and discrete fibrinoid necrosis. The histological findings were indicative of Horton's disease, but no typical clinical features were present. The case illustrates the difficulties involved in diagnosing inflammatory aortic diseases where it may be challenging to arrive at a specific diagnosis despite the knowledge of medical history, and available macroscopic and histological findings.
Citace poskytuje Crossref.org
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- $a Handlos, Petr $u Department of Forensic Medicine, University Hospital Ostrava, CZ-708 52, Ostrava, Czech Republic ; Department of Intensive Medicine and Forensic Studies, Faculty of Medicine, Ostrava University, CZ-703 00, Ostrava, Czech Republic
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- $a Giant cell aortitis / $c P. Handlos, M. Uvíra, M. Dokoupil, O. Klabal, K. Handlosová
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- $a Inflammatory aortic diseases are broadly classified into three categories according to the degree of inflammation: atherosclerosis, atherosclerosis with excessive inflammation, and aortitis/periaortitis. This paper presents a case of a 39-year old man with aneurysmal dilatation of thoracic aorta and aortic valve insufficiency. The aortic wall showed thickening and wrinkled "tree bark" appearance as well as apparent scarring of the intima. Histological examination revealed intimal hyperplasia, a granulomatous/giant cell pattern in the inner tunica media, a few epithelioid macrophages, abundant chronic lymphoplasmacytic and histiocytic inflammation and discrete fibrinoid necrosis. The histological findings were indicative of Horton's disease, but no typical clinical features were present. The case illustrates the difficulties involved in diagnosing inflammatory aortic diseases where it may be challenging to arrive at a specific diagnosis despite the knowledge of medical history, and available macroscopic and histological findings.
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- $a Uvíra, Matěj $u Department of Forensic Medicine, University Hospital Ostrava, CZ-708 52, Ostrava, Czech Republic ; The Fingerland Department of Pathology, Faculty of Medicine in Hradec Kralove, Charles University, CZ-500 03, Hradec Kralove, Czech Republic
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