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Giant cell aortitis
P. Handlos, M. Uvíra, M. Dokoupil, O. Klabal, K. Handlosová
Language English Country United States
Document type Case Reports, Journal Article
Grant support
RVO - FNOs/2017.
Ministerstvo Zdravotnictví Ceské Republiky - International
- MeSH
- Aortic Aneurysm, Thoracic pathology MeSH
- Aorta pathology MeSH
- Aortic Valve Insufficiency pathology MeSH
- Plaque, Atherosclerotic pathology MeSH
- Adult MeSH
- Ventricular Dysfunction, Left etiology MeSH
- Fibrosis pathology MeSH
- Hyperplasia MeSH
- Humans MeSH
- Macrophages pathology MeSH
- Myocardium pathology MeSH
- Coronary Artery Disease pathology MeSH
- Giant Cell Arteritis pathology MeSH
- Tunica Media pathology MeSH
- Check Tag
- Adult MeSH
- Humans MeSH
- Male MeSH
- Publication type
- Journal Article MeSH
- Case Reports MeSH
Inflammatory aortic diseases are broadly classified into three categories according to the degree of inflammation: atherosclerosis, atherosclerosis with excessive inflammation, and aortitis/periaortitis. This paper presents a case of a 39-year old man with aneurysmal dilatation of thoracic aorta and aortic valve insufficiency. The aortic wall showed thickening and wrinkled "tree bark" appearance as well as apparent scarring of the intima. Histological examination revealed intimal hyperplasia, a granulomatous/giant cell pattern in the inner tunica media, a few epithelioid macrophages, abundant chronic lymphoplasmacytic and histiocytic inflammation and discrete fibrinoid necrosis. The histological findings were indicative of Horton's disease, but no typical clinical features were present. The case illustrates the difficulties involved in diagnosing inflammatory aortic diseases where it may be challenging to arrive at a specific diagnosis despite the knowledge of medical history, and available macroscopic and histological findings.
References provided by Crossref.org
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- $a Handlos, Petr $u Department of Forensic Medicine, University Hospital Ostrava, CZ-708 52, Ostrava, Czech Republic ; Department of Intensive Medicine and Forensic Studies, Faculty of Medicine, Ostrava University, CZ-703 00, Ostrava, Czech Republic
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- $a Giant cell aortitis / $c P. Handlos, M. Uvíra, M. Dokoupil, O. Klabal, K. Handlosová
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- $a Inflammatory aortic diseases are broadly classified into three categories according to the degree of inflammation: atherosclerosis, atherosclerosis with excessive inflammation, and aortitis/periaortitis. This paper presents a case of a 39-year old man with aneurysmal dilatation of thoracic aorta and aortic valve insufficiency. The aortic wall showed thickening and wrinkled "tree bark" appearance as well as apparent scarring of the intima. Histological examination revealed intimal hyperplasia, a granulomatous/giant cell pattern in the inner tunica media, a few epithelioid macrophages, abundant chronic lymphoplasmacytic and histiocytic inflammation and discrete fibrinoid necrosis. The histological findings were indicative of Horton's disease, but no typical clinical features were present. The case illustrates the difficulties involved in diagnosing inflammatory aortic diseases where it may be challenging to arrive at a specific diagnosis despite the knowledge of medical history, and available macroscopic and histological findings.
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- $a Uvíra, Matěj $u Department of Forensic Medicine, University Hospital Ostrava, CZ-708 52, Ostrava, Czech Republic ; The Fingerland Department of Pathology, Faculty of Medicine in Hradec Kralove, Charles University, CZ-500 03, Hradec Kralove, Czech Republic
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- $a Dokoupil, Marek $u Department of Forensic Medicine, University Hospital Ostrava, CZ-708 52, Ostrava, Czech Republic ; Department of Epidemiology and Public Health, Faculty of Medicine, Ostrava University, CZ-703 00, Ostrava, Czech Republic
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- $a Handlosová, Klára $u Department of Forensic Medicine, University Hospital Ostrava, CZ-708 52, Ostrava, Czech Republic. marecova.klara@seznam.cz $7 xx0263805
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