-
Something wrong with this record ?
Biological Evaluation of Polyvinyl Alcohol Hydrogels Enriched by Hyaluronic Acid and Hydroxyapatite
P. Chocholata, V. Kulda, J. Dvorakova, J. Kolaja Dobra, V. Babuska
Language English Country Switzerland
Document type Journal Article
Grant support
CZ.02.1.01/0.0/0.0/16_019/0000787
Ministerstvo Školství, Mládeže a Tělovýchovy
NLK
Free Medical Journals
from 2000
Freely Accessible Science Journals
from 2000
PubMed Central
from 2007
Europe PubMed Central
from 2007
ProQuest Central
from 2000-03-01
Open Access Digital Library
from 2000-01-01
Open Access Digital Library
from 2007-01-01
Health & Medicine (ProQuest)
from 2000-03-01
ROAD: Directory of Open Access Scholarly Resources
from 2000
PubMed
32784986
DOI
10.3390/ijms21165719
Knihovny.cz E-resources
- MeSH
- Biocompatible Materials metabolism pharmacology MeSH
- Cell Adhesion drug effects MeSH
- Hydrogels chemistry MeSH
- Durapatite metabolism pharmacology MeSH
- Hyaluronic Acid metabolism pharmacology MeSH
- Humans MeSH
- Cell Line, Tumor MeSH
- Osteoblasts metabolism MeSH
- Polyvinyl Alcohol metabolism pharmacology MeSH
- Cell Proliferation drug effects MeSH
- Materials Testing methods MeSH
- Tissue Engineering methods MeSH
- Tissue Scaffolds chemistry MeSH
- Cell Survival drug effects MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
This study aimed to develop polyvinyl alcohol (PVA) -based scaffold enriched with hyaluronic acid (HA) and hydroxyapatite (HAp) using physical crosslinking by freezing-thawing method. We accomplished biological evaluation of scaffolds, swelling degree, bioactivity assessment, and hemolytic test. The results showed that all types of scaffolds should be safe for use in the human body. The culturing of human osteoblast-like cells MG-63 and their proliferation showed better adhesion of cells due to the presence of HA and confirmed better proliferation depending on the amount of HAp. This paper gives the optimal composition of the scaffold and the optimal amount of the particular components of the scaffold. Based on our results we concluded that the best PVA/HA/HAp combination is in the ratio 3:1:2.
References provided by Crossref.org
- 000
- 00000naa a2200000 a 4500
- 001
- bmc21012275
- 003
- CZ-PrNML
- 005
- 20210507102646.0
- 007
- ta
- 008
- 210420s2020 sz f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.3390/ijms21165719 $2 doi
- 035 __
- $a (PubMed)32784986
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a sz
- 100 1_
- $a Chocholata, Petra $u Department of Medical Chemistry and Biochemistry, Faculty of Medicine in Pilsen, Charles University, Karlovarska 48, 301 66 Plzen, Czech Republic
- 245 10
- $a Biological Evaluation of Polyvinyl Alcohol Hydrogels Enriched by Hyaluronic Acid and Hydroxyapatite / $c P. Chocholata, V. Kulda, J. Dvorakova, J. Kolaja Dobra, V. Babuska
- 520 9_
- $a This study aimed to develop polyvinyl alcohol (PVA) -based scaffold enriched with hyaluronic acid (HA) and hydroxyapatite (HAp) using physical crosslinking by freezing-thawing method. We accomplished biological evaluation of scaffolds, swelling degree, bioactivity assessment, and hemolytic test. The results showed that all types of scaffolds should be safe for use in the human body. The culturing of human osteoblast-like cells MG-63 and their proliferation showed better adhesion of cells due to the presence of HA and confirmed better proliferation depending on the amount of HAp. This paper gives the optimal composition of the scaffold and the optimal amount of the particular components of the scaffold. Based on our results we concluded that the best PVA/HA/HAp combination is in the ratio 3:1:2.
- 650 _2
- $a biokompatibilní materiály $x metabolismus $x farmakologie $7 D001672
- 650 _2
- $a buněčná adheze $x účinky léků $7 D002448
- 650 _2
- $a nádorové buněčné linie $7 D045744
- 650 _2
- $a proliferace buněk $x účinky léků $7 D049109
- 650 _2
- $a viabilita buněk $x účinky léků $7 D002470
- 650 _2
- $a hydroxyapatit $x metabolismus $x farmakologie $7 D017886
- 650 _2
- $a lidé $7 D006801
- 650 _2
- $a kyselina hyaluronová $x metabolismus $x farmakologie $7 D006820
- 650 _2
- $a hydrogely $x chemie $7 D020100
- 650 _2
- $a testování materiálů $x metody $7 D008422
- 650 _2
- $a osteoblasty $x metabolismus $7 D010006
- 650 _2
- $a polyvinylalkohol $x metabolismus $x farmakologie $7 D011142
- 650 _2
- $a tkáňové inženýrství $x metody $7 D023822
- 650 _2
- $a tkáňové podpůrné struktury $x chemie $7 D054457
- 655 _2
- $a časopisecké články $7 D016428
- 700 1_
- $a Kulda, Vlastimil $u Department of Medical Chemistry and Biochemistry, Faculty of Medicine in Pilsen, Charles University, Karlovarska 48, 301 66 Plzen, Czech Republic
- 700 1_
- $a Dvorakova, Jana $u Department of Medical Chemistry and Biochemistry, Faculty of Medicine in Pilsen, Charles University, Karlovarska 48, 301 66 Plzen, Czech Republic
- 700 1_
- $a Kolaja Dobra, Jana $u Department of Medical Chemistry and Biochemistry, Faculty of Medicine in Pilsen, Charles University, Karlovarska 48, 301 66 Plzen, Czech Republic
- 700 1_
- $a Babuska, Vaclav $u Department of Medical Chemistry and Biochemistry, Faculty of Medicine in Pilsen, Charles University, Karlovarska 48, 301 66 Plzen, Czech Republic
- 773 0_
- $w MED00176142 $t International journal of molecular sciences $x 1422-0067 $g Roč. 21, č. 16 (2020)
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/32784986 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y p $z 0
- 990 __
- $a 20210420 $b ABA008
- 991 __
- $a 20210507102646 $b ABA008
- 999 __
- $a ok $b bmc $g 1650609 $s 1132654
- BAS __
- $a 3
- BAS __
- $a PreBMC
- BMC __
- $a 2020 $b 21 $c 16 $e 20200810 $i 1422-0067 $m International journal of molecular sciences $n Int J Mol Sci $x MED00176142
- GRA __
- $a CZ.02.1.01/0.0/0.0/16_019/0000787 $p Ministerstvo Školství, Mládeže a Tělovýchovy
- LZP __
- $a Pubmed-20210420
