• Something wrong with this record ?

Muscle strength and physical performance, rather than muscle mass, correlate with mortality in end-stage liver disease

SS. Sidhu, K. Saggar, O. Goyal, T. Varshney, H. Kishore, N. Bansal, SS. Sidhu

. 2021 ; 33 (4) : 555-564. [pub] 20210401

Language English Country Great Britain

Document type Journal Article

Persistent link   https://www.medvik.cz/link/bmc21025893

OBJECTIVES: Sarcopenia is characterized by the loss of skeletal muscle mass, strength and performance. The study aimed to provide cut off values of various Sarcopenia parameters [computerized tomography skeletal muscle index (SMI), handgrip strength (HGS), gait velocity and chair stand] to predict mortality in end-stage liver disease (ESLD). METHODS: The inclusion criteria were age 18-75 years, model for end-stage liver disease > 15. All patients with advanced heart, lung, kidney diseases, active malignancy were excluded from the study. Sarcopenia indices were compared between survivors and non-survivors to find cut off value for prediction of mortality in ESLD patients. RESULTS: One hundred sixty-one subjects suffering from ESLD were enrolled. The cutoff value of the SMI to identify high risk of mortality in sarcopenia patients is ≤21.2 cm2/m2, area under the curve (AUC) 0.537 [95% confidence interval (CI) 0.456-0.616]. The cutoff value of the hand grip strength to identify high-risk mortality is ≤25.3 kilogram-force, AUC 0.682 (95% CI 0.604-0.753). The cutoff value of the gait velocity for the same is as ≤0.84 m/s, AUC 0.551 (95% CI 0.459-0.641). The cutoff value of the chair stand is ≥20.9 seconds, AUC 0.956 (95% CI 0.910-0.983). In the multivariate analysis, HGS, gait velocity and chair stand correlated with mortality. CONCLUSION: The current study is a comprehensive Asian study that gives the cut off values of Sarcopenia: muscle mass, strength and performance which identify high risk of mortality in ESLD patients. Muscle strength and performance correlated with mortality.

References provided by Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc21025893
003      
CZ-PrNML
005      
20211026133413.0
007      
ta
008      
211013s2021 xxk f 000 0|eng||
009      
AR
024    7_
$a 10.1097/MEG.0000000000001761 $2 doi
035    __
$a (PubMed)32433422
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xxk
100    1_
$a Sidhu, Sandeep Singh $u Departments of Gastroenterology
245    10
$a Muscle strength and physical performance, rather than muscle mass, correlate with mortality in end-stage liver disease / $c SS. Sidhu, K. Saggar, O. Goyal, T. Varshney, H. Kishore, N. Bansal, SS. Sidhu
520    9_
$a OBJECTIVES: Sarcopenia is characterized by the loss of skeletal muscle mass, strength and performance. The study aimed to provide cut off values of various Sarcopenia parameters [computerized tomography skeletal muscle index (SMI), handgrip strength (HGS), gait velocity and chair stand] to predict mortality in end-stage liver disease (ESLD). METHODS: The inclusion criteria were age 18-75 years, model for end-stage liver disease > 15. All patients with advanced heart, lung, kidney diseases, active malignancy were excluded from the study. Sarcopenia indices were compared between survivors and non-survivors to find cut off value for prediction of mortality in ESLD patients. RESULTS: One hundred sixty-one subjects suffering from ESLD were enrolled. The cutoff value of the SMI to identify high risk of mortality in sarcopenia patients is ≤21.2 cm2/m2, area under the curve (AUC) 0.537 [95% confidence interval (CI) 0.456-0.616]. The cutoff value of the hand grip strength to identify high-risk mortality is ≤25.3 kilogram-force, AUC 0.682 (95% CI 0.604-0.753). The cutoff value of the gait velocity for the same is as ≤0.84 m/s, AUC 0.551 (95% CI 0.459-0.641). The cutoff value of the chair stand is ≥20.9 seconds, AUC 0.956 (95% CI 0.910-0.983). In the multivariate analysis, HGS, gait velocity and chair stand correlated with mortality. CONCLUSION: The current study is a comprehensive Asian study that gives the cut off values of Sarcopenia: muscle mass, strength and performance which identify high risk of mortality in ESLD patients. Muscle strength and performance correlated with mortality.
650    _2
$a mladiství $7 D000293
650    _2
$a dospělí $7 D000328
650    _2
$a senioři $7 D000368
650    _2
$a průřezové studie $7 D003430
650    12
$a konečné stadium selhání jater $x diagnóza $7 D058625
650    _2
$a síla ruky $7 D018737
650    _2
$a lidé $7 D006801
650    _2
$a lidé středního věku $7 D008875
650    _2
$a svalová síla $7 D053580
650    _2
$a kosterní svaly $x diagnostické zobrazování $7 D018482
650    _2
$a tělesná a funkční výkonnost $7 D000076604
650    12
$a sarkopenie $x diagnóza $7 D055948
650    _2
$a stupeň závažnosti nemoci $7 D012720
650    _2
$a mladý dospělý $7 D055815
655    _2
$a časopisecké články $7 D016428
700    1_
$a Saggar, Kavita $u Radiodiagnosis, Dayanand Medical College and Hospital
700    1_
$a Goyal, Omesh $u Departments of Gastroenterology
700    1_
$a Varshney, Tarun $u Departments of Gastroenterology
700    1_
$a Kishore, Harsh $u Departments of Gastroenterology
700    1_
$a Bansal, Namita $u Department of Gastroenterology, Dayanand Medical College and Hospital Ludhiana, India
700    1_
$a Sidhu, Samarth Singh $u First Faculty of Medicine, Charles University, Prague, Czechia
773    0_
$w MED00001618 $t European journal of gastroenterology & hepatology $x 1473-5687 $g Roč. 33, č. 4 (2021), s. 555-564
856    41
$u https://pubmed.ncbi.nlm.nih.gov/32433422 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y p $z 0
990    __
$a 20211013 $b ABA008
991    __
$a 20211026133419 $b ABA008
999    __
$a ok $b bmc $g 1714796 $s 1146400
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2021 $b 33 $c 4 $d 555-564 $e 20210401 $i 1473-5687 $m European journal of gastroenterology & hepatology $n Eur J Gastroenterol Hepatol $x MED00001618
LZP    __
$a Pubmed-20211013
Back

Find record

Citation metrics

Archiving options