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The ω-3 Polyunsaturated Fatty Acids and Oxidative Stress in Long-Term Parenteral Nutrition Dependent Adult Patients: Functional Lipidomics Approach

V. Kosek, M. Heczkova, F. Novak, E. Meisnerova, O. Novákova, J. Zelenka, K. Bechynska, N. Vrzacova, J. Suttnar, A. Hlavackova, H. Dankova, M. Bratova, N. Daskova, H. Malinska, O. Oliyarnyk, P. Wohl, H. Bastova, J. Hajslova, M. Cahova

. 2020 ; 12 (8) : . [pub] 20200806

Jazyk angličtina Země Švýcarsko

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc21012282

Grantová podpora
15 28745A Ministerstvo Zdravotnictví Ceské Republiky
MH CZ-DRO ("Institute for Clinical and Experimental Medicine IKEM, IN 00023001) Ministerstvo Zdravotnictví Ceské Republiky
AIIHHP: CZ.02.1.01/0.0/0.0/16_025/0007428, OP RDE Ministerstvo Školství, Mládeže a Tělovýchovy

Omega-3 polyunsaturated fatty acids (ω-3PUFAs) are introduced into parenteral nutrition (PN) as hepatoprotective but may be susceptible to the lipid peroxidation while olive oil (OO) is declared more peroxidation resistant. We aimed to estimate how the lipid composition of PN mixture affects plasma and erythrocyte lipidome and the propensity of oxidative stress. A cross-sectional comparative study was performed in a cohort of adult patients who were long-term parenterally administered ω-3 PUFAs without (FO/-, n = 9) or with (FO/OO, n = 13) olive oil and healthy age- and sex-matched controls, (n = 30). Lipoperoxidation assessed as plasma and erythrocyte malondialdehyde content was increased in both FO/- and FO/OO groups but protein oxidative stress (protein carbonyls in plasma) and low redox status (GSH/GSSG in erythrocytes) was detected only in the FO/- subcohort. The lipidome of all subjects receiving ω-3 PUFAs was enriched with lipid species containing ω-3 PUFAs (FO/-˃FO/OO). Common characteristic of all PN-dependent patients was high content of fatty acyl-esters of hydroxy-fatty acids (FAHFAs) in plasma while acylcarnitines and ceramides were enriched in erythrocytes. Plasma and erythrocyte concentrations of plasmanyls and plasmalogens (endogenous antioxidants) were decreased in both patient groups with a significantly more pronounced effect in FO/-. We confirmed the protective effect of OO in PN mixtures containing ω-3 PUFAs.

Citace poskytuje Crossref.org

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