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Chitosan-glucan complex hollow fibers reinforced collagen wound dressing embedded with aloe vera. II. Multifunctional properties to promote cutaneous wound healing
AM. Abdel-Mohsen, J. Frankova, RM. Abdel-Rahman, AA. Salem, NM. Sahffie, I. Kubena, J. Jancar
Jazyk angličtina Země Nizozemsko
Typ dokumentu srovnávací studie, časopisecké články
- MeSH
- Aloe * chemie MeSH
- antibakteriální látky chemie izolace a purifikace farmakologie MeSH
- Bacteria účinky léků růst a vývoj MeSH
- chitosan chemie izolace a purifikace farmakologie MeSH
- fibrilární kolageny chemie izolace a purifikace farmakologie MeSH
- glukany chemie izolace a purifikace farmakologie MeSH
- hojení ran účinky léků MeSH
- kultivované buňky MeSH
- kůže účinky léků zranění patologie MeSH
- lidé MeSH
- modely nemocí na zvířatech MeSH
- mycelium * chemie MeSH
- obvazy * MeSH
- potkani Wistar MeSH
- rány a poranění farmakoterapie patologie MeSH
- rostlinné extrakty chemie izolace a purifikace farmakologie MeSH
- Schizophyllum * chemie MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- mužské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- srovnávací studie MeSH
This study presents an innovative multifunctional system in fabricating new functional wound dressing (FWD) products that could be used for skin regeneration, especially in cases of infected chronic wounds and ulcers. The innovation is based on the extraction, characterization, and application of collagen (CO)/chitosan-glucan complex hollow fibers (CSGC)/aloe vera (AV) as a novel FWS. For the first time, specific hollow fibers were extracted with controlled inner (500-900 nm)/outer (2-3 µm) diameters from mycelium of Schizophyllum commune. Further on, research and evaluation of morphology, hydrolytic stability, and swelling characteristics of CO/CSGC@AV were carried out. The obtained FWS showed high hydrolytic stability with enhanced swelling characteristics compared to native collagen. The hemostatic effect of FWS increased significantly in the presence of CSGC, compared to native CO and displayed excellent biocompatibility which was tested by using normal human dermal fibroblast (NHDF). The FWS showed high antibacterial activity against different types of bacteria (positive/negative grams). From in vivo measurements, the novel FWS increased the percentage of wound closure after one week of treatment. All these results imply that the new CO/CSGC@AV-FWD has the potential for clinical skin regeneration and applying for controlled drug release.
Pathology Department National Research Centre 33 EL Buhouth St Dokki Giza 12622 Egypt
Pharmacology Department National Research Centre 33 EL Buhouth St Dokki Giza 12622 Egypt
Citace poskytuje Crossref.org
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- $a Abdel-Mohsen, A M $u CEITEC-Central European Institute of Technology, Brno University of Technology, Purkyňova 656/123, Brno 612 00, Czechia; SCITEG, a.s., Brno, Czechia; Pretreatment and Finishing of Cellulosic based Textiles Department, Textile Industries Research Division, National Research Centre, 33 EL Buhouth St., Dokki, Giza 12622, Egypt. Electronic address: abdel-mohsen@ceitec.vutbr.cz
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