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Insulin resistance is associated with verbal memory impairment in bipolar disorders
V. Salvi, G. Di Salvo, J. Korčáková, S. Torriero, E. Aragno, M. Kolenič, M. Ungrmanová, G. Maina, C. Mencacci, T. Hajek
Jazyk angličtina Země Nizozemsko
Typ dokumentu časopisecké články, práce podpořená grantem
Grantová podpora
142,255
CIHR - Canada
- MeSH
- bipolární porucha * komplikace MeSH
- inzulinová rezistence * MeSH
- lidé MeSH
- neuropsychologické testy MeSH
- paměť MeSH
- poruchy paměti MeSH
- průřezové studie MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
BACKGROUND: Cognitive impairment contributes to deterioration in social, family and work functioning in Bipolar Disorder (BD). Cognitive deficits are present not only during, but also outside of mood episodes. Insulin resistance (IR) impairs cognitive functioning and is frequent in participants with BD. Thus, we hypothesized that IR might contribute to cognitive deficits in remitted BD participants. METHODS: We acquired biochemical (fasting insulin, glucose, lipids) cognitive (California Verbal Learning Test, Digit Span) measures from 100 euthymic participants with BD type I or II. IR was diagnosed using HOMA-IR. RESULTS: BD participants with IR displayed worse composite verbal memory score (-0.38 vs 0.17; F(1, 8.23)=17.90; p = 0.003), while composite working memory scores were comparable in patients with or without IR (-0.20 vs 0.07; F(1, 6.05)=1.64; p = 0.25). Insulin resistance remained significantly associated with composite verbal memory scores (F(1, 47.99)=9.82, p = 0.003) even when we controlled for levels of lipids. The association between IR and verbal memory was not confounded by exposure to antipsychotics, which were not associated with worse cognitive performance (F(1, 2.07)=5.95, p = 0.13). LIMITATIONS: The main limitation is the cross-sectional design, which does not allow us to rule out reverse causation. CONCLUSIONS: We demonstrated that among remitted BD participants without diabetes mellitus, IR was significantly associated with verbal memory performance, even when we controlled for other relevant metabolic or treatment variables. These findings raise the possibility that early detection and treatment of IR, which is reversible, could possibly improve cognitive functioning in at least some BD participants.
3rd School of Medicine Charles University Prague Czech Republic
Department of Neuroscience ASST Fatebenefratelli Sacco Milan Italy
Department of Neuroscience University of Turin Turin Italy
Department of Psychiatry Dalhousie University Halifax NS Canada
Citace poskytuje Crossref.org
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- $a BACKGROUND: Cognitive impairment contributes to deterioration in social, family and work functioning in Bipolar Disorder (BD). Cognitive deficits are present not only during, but also outside of mood episodes. Insulin resistance (IR) impairs cognitive functioning and is frequent in participants with BD. Thus, we hypothesized that IR might contribute to cognitive deficits in remitted BD participants. METHODS: We acquired biochemical (fasting insulin, glucose, lipids) cognitive (California Verbal Learning Test, Digit Span) measures from 100 euthymic participants with BD type I or II. IR was diagnosed using HOMA-IR. RESULTS: BD participants with IR displayed worse composite verbal memory score (-0.38 vs 0.17; F(1, 8.23)=17.90; p = 0.003), while composite working memory scores were comparable in patients with or without IR (-0.20 vs 0.07; F(1, 6.05)=1.64; p = 0.25). Insulin resistance remained significantly associated with composite verbal memory scores (F(1, 47.99)=9.82, p = 0.003) even when we controlled for levels of lipids. The association between IR and verbal memory was not confounded by exposure to antipsychotics, which were not associated with worse cognitive performance (F(1, 2.07)=5.95, p = 0.13). LIMITATIONS: The main limitation is the cross-sectional design, which does not allow us to rule out reverse causation. CONCLUSIONS: We demonstrated that among remitted BD participants without diabetes mellitus, IR was significantly associated with verbal memory performance, even when we controlled for other relevant metabolic or treatment variables. These findings raise the possibility that early detection and treatment of IR, which is reversible, could possibly improve cognitive functioning in at least some BD participants.
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- $a Di Salvo, Gabriele $u Department of Neuroscience, University of Turin, Turin, Italy
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- $a Kolenič, Marian $u National Institute of Mental Health, Klecany, Czech Republic; 3rd School of Medicine, Charles University, Prague, Czech Republic
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- $a Hajek, Tomas $u National Institute of Mental Health, Klecany, Czech Republic; Department of Psychiatry, Dalhousie University, Halifax, NS, Canada. Electronic address: tomas.hajek@dal.ca
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