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The Interplay between CD27dull and CD27bright B Cells Ensures the Flexibility, Stability, and Resilience of Human B Cell Memory
O. Grimsholm, E. Piano Mortari, AN. Davydov, M. Shugay, AS. Obraztsova, C. Bocci, E. Marasco, V. Marcellini, A. Aranburu, C. Farroni, DA. Silvestris, C. Cristofoletti, E. Giorda, M. Scarsella, S. Cascioli, S. Barresi, V. Lougaris, A. Plebani, C....
Jazyk angličtina Země Spojené státy americké
Typ dokumentu časopisecké články, práce podpořená grantem
NLK
Cell Press Free Archives
od 2012
Directory of Open Access Journals
od 2012
Free Medical Journals
od 2012
Freely Accessible Science Journals
od 2012-01-26
Open Access Digital Library
od 2012-01-26
Open Access Digital Library
od 2012-01-01
- MeSH
- antigeny CD27 metabolismus MeSH
- B-lymfocyty imunologie MeSH
- dárci tkání MeSH
- dítě MeSH
- dospělí MeSH
- genetická transkripce MeSH
- imunologická paměť * genetika MeSH
- kojenec MeSH
- lidé středního věku MeSH
- lidé MeSH
- modely imunologické MeSH
- novorozenec MeSH
- předškolní dítě MeSH
- přesmyk imunoglobulinových tříd genetika MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- somatická hypermutace imunoglobulinových genů genetika MeSH
- stanovení celkové genové exprese MeSH
- těhotenství MeSH
- variabilní oblast imunoglobulinu genetika MeSH
- Check Tag
- dítě MeSH
- dospělí MeSH
- kojenec MeSH
- lidé středního věku MeSH
- lidé MeSH
- novorozenec MeSH
- předškolní dítě MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- těhotenství MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
Memory B cells (MBCs) epitomize the adaptation of the immune system to the environment. We identify two MBC subsets in peripheral blood, CD27dull and CD27bright MBCs, whose frequency changes with age. Heavy chain variable region (VH) usage, somatic mutation frequency replacement-to-silent ratio, and CDR3 property changes, reflecting consecutive selection of highly antigen-specific, low cross-reactive antibody variants, all demonstrate that CD27dull and CD27bright MBCs represent sequential MBC developmental stages, and stringent antigen-driven pressure selects CD27dull into the CD27bright MBC pool. Dynamics of human MBCs are exploited in pregnancy, when 50% of maternal MBCs are lost and CD27dull MBCs transit to the more differentiated CD27bright stage. In the postpartum period, the maternal MBC pool is replenished by the expansion of persistent CD27dull clones. Thus, the stability and flexibility of human B cell memory is ensured by CD27dull MBCs that expand and differentiate in response to change.
Center of Life Sciences Skolkovo Institute of Science and Technology 101000 Moscow Russia
Central European Institute of Technology 625 00 Brno Czech Republic
Department of Experimental and Clinical Sciences University of Brescia 25121 Brescia Italy
Department of Pediatrics Sapienza University of Rome 00161 Rome Italy
Division of Rheumatology Bambino Gesù Children's Hospital IRCCS 00146 Roma Italy
Genetics and Rare Diseases Research Division Bambino Gesù Children's Hospital 00146 Rome Italy
Istituto Dermopatico dell'Immacolata IRCCS 00167 Rome Italy
Oncohaematology Department Bambino Gesù Children's Hospital IRCCS 00146 Rome Italy
Otorhinolaryngology Unit Bambino Gesù Children's Hospital IRCSS 00146 Rome Italy
Pediatric and Infectious Disease Unit Bambino Gesù Children's Hospital IRCCS 00146 Rome Italy
Pediatric Immunology Unit Policlinico Tor Vergata University of Rome Tor Vergata 00133 Rome Italy
School of Medicine University of Tor Vergata 00133 Rome Italy
Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry 117997 Moscow Russia
Citace poskytuje Crossref.org
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