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Factors affecting the function of the mitochondrial membrane permeability transition pore and their role in evaluation of calcium retention capacity values

Z. Drahota, R. Endlicher, O. Kučera, D. Rychtrmoc, Z. Červinková

. 2020 ; 69 (3) : 491-499. [pub] 20200529

Jazyk angličtina Země Česko

Typ dokumentu hodnotící studie, časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc21015646

Values of the calcium retention capacity (CRC) of rat liver mitochondria are highly dependent on the experimental conditions used. When increasing amounts of added calcium chloride are used (1.25-10 nmol), the values of the CRC increase 3-fold. When calcium is added in 75 s intervals, the CRC values increase by 30 % compared with 150 s interval additions. CRC values are not dependent on the calcium/protein ratio in the measured sample in our experimental design. We also show that a more detailed evaluation of the fluorescence curves can provide new information about mitochondrial permeability transition pore opening after calcium is added.

Citace poskytuje Crossref.org

Bibliografie atd.

Literatura

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