-
Something wrong with this record ?
COVID-19 and the immune system
J. Paces, Z. Strizova, D. Smrz, J. Cerny
Language English Country Czech Republic
Document type Journal Article, Review
NLK
Directory of Open Access Journals
from 1991
Free Medical Journals
from 1998
PubMed Central
from 2020
ProQuest Central
from 2005-01-01
Medline Complete (EBSCOhost)
from 2006-01-01
Nursing & Allied Health Database (ProQuest)
from 2005-01-01
Health & Medicine (ProQuest)
from 2005-01-01
ROAD: Directory of Open Access Scholarly Resources
from 1998
- MeSH
- Adaptive Immunity MeSH
- Betacoronavirus immunology MeSH
- COVID-19 MeSH
- Host-Pathogen Interactions immunology MeSH
- Coronavirus Infections immunology prevention & control MeSH
- Humans MeSH
- Pandemics MeSH
- Immunity, Innate MeSH
- SARS-CoV-2 MeSH
- COVID-19 Vaccines MeSH
- Pneumonia, Viral immunology MeSH
- Viral Vaccines MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Review MeSH
A close interaction between the virus SARS-CoV-2 and the immune system of an individual results in a diverse clinical manifestation of the COVID-19 disease. While adaptive immune responses are essential for SARS-CoV-2 virus clearance, the innate immune cells, such as macrophages, may contribute, in some cases, to the disease progression. Macrophages have shown a significant production of IL-6, suggesting they may contribute to the excessive inflammation in COVID-19 disease. Macrophage Activation Syndrome may further explain the high serum levels of CRP, which are normally lacking in viral infections. In adaptive immune responses, it has been revealed that cytotoxic CD8+ T cells exhibit functional exhaustion patterns, such as the expression of NKG2A, PD-1, and TIM-3. Since SARS-CoV-2 restrains antigen presentation by downregulating MHC class I and II molecules and, therefore, inhibits the T cell-mediated immune responses, humoral immune responses also play a substantial role. Specific IgA response appears to be stronger and more persistent than the IgM response. Moreover, IgM and IgG antibodies show similar dynamics in COVID-19 disease.
References provided by Crossref.org
Literatura
- 000
- 00000naa a2200000 a 4500
- 001
- bmc21015655
- 003
- CZ-PrNML
- 005
- 20210618141658.0
- 007
- ta
- 008
- 210604s2020 xr f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.33549/physiolres.934492 $2 doi
- 035 __
- $a (PubMed)32469225
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a xr
- 100 1_
- $a Pačes, Jan, $d 1967- $7 jo2005274207 $u Laboratory of Cell Immunology, Faculty of Science, Charles University, Prague, Czech Republic
- 245 10
- $a COVID-19 and the immune system / $c J. Paces, Z. Strizova, D. Smrz, J. Cerny
- 504 __
- $a Literatura
- 520 9_
- $a A close interaction between the virus SARS-CoV-2 and the immune system of an individual results in a diverse clinical manifestation of the COVID-19 disease. While adaptive immune responses are essential for SARS-CoV-2 virus clearance, the innate immune cells, such as macrophages, may contribute, in some cases, to the disease progression. Macrophages have shown a significant production of IL-6, suggesting they may contribute to the excessive inflammation in COVID-19 disease. Macrophage Activation Syndrome may further explain the high serum levels of CRP, which are normally lacking in viral infections. In adaptive immune responses, it has been revealed that cytotoxic CD8+ T cells exhibit functional exhaustion patterns, such as the expression of NKG2A, PD-1, and TIM-3. Since SARS-CoV-2 restrains antigen presentation by downregulating MHC class I and II molecules and, therefore, inhibits the T cell-mediated immune responses, humoral immune responses also play a substantial role. Specific IgA response appears to be stronger and more persistent than the IgM response. Moreover, IgM and IgG antibodies show similar dynamics in COVID-19 disease.
- 650 _2
- $a adaptivní imunita $7 D056704
- 650 _2
- $a Betacoronavirus $x imunologie $7 D000073640
- 650 _2
- $a COVID-19 $7 D000086382
- 650 _2
- $a vakcíny proti COVID-19 $7 D000086663
- 650 _2
- $a koronavirové infekce $x imunologie $x prevence a kontrola $7 D018352
- 650 _2
- $a interakce hostitele a patogenu $x imunologie $7 D054884
- 650 _2
- $a lidé $7 D006801
- 650 _2
- $a přirozená imunita $7 D007113
- 650 _2
- $a pandemie $7 D058873
- 650 _2
- $a virová pneumonie $x imunologie $7 D011024
- 650 _2
- $a SARS-CoV-2 $7 D000086402
- 650 _2
- $a virové vakcíny $7 D014765
- 655 _2
- $a časopisecké články $7 D016428
- 655 _2
- $a přehledy $7 D016454
- 700 1_
- $a Střížová, Zuzana, $d 1991- $7 hka20191025149 $u Department of Immunology, Second Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic
- 700 1_
- $a Smrž, Daniel, $d 1975- $7 uk2007350347 $u Department of Immunology, Second Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic
- 700 1_
- $a Černý, Jan, $d 1970- $7 jn19981002627 $u Laboratory of Cell Immunology, Faculty of Science, Charles University, Prague, Czech Republic
- 773 0_
- $w MED00003824 $t Physiological research $x 1802-9973 $g Roč. 69, č. 3 (2020), s. 379-388
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/32469225 $y Pubmed
- 910 __
- $a ABA008 $b A 4120 $c 266 $y p $z 0
- 990 __
- $a 20210604 $b ABA008
- 991 __
- $a 20210611185821 $b ABA008
- 999 __
- $a ok $b bmc $g 1664036 $s 1136063
- BAS __
- $a 3
- BAS __
- $a PreBMC
- BMC __
- $a 2020 $b 69 $c 3 $d 379-388 $e 20200529 $i 1802-9973 $m Physiological research $n Physiol. Res. (Print) $x MED00003824
- LZP __
- $b NLK118 $a Pubmed-20210604
