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Long-term intake of 9-PAHPA or 9-OAHPA modulates favorably the basal metabolism and exerts an insulin sensitizing effect in obesogenic diet-fed mice
M. Benlebna, L. Balas, B. Bonafos, L. Pessemesse, G. Fouret, C. Vigor, S. Gaillet, J. Grober, F. Bernex, JF. Landrier, O. Kuda, T. Durand, C. Coudray, F. Casas, C. Feillet-Coudray
Language English Country Germany
Document type Journal Article
NLK
ProQuest Central
from 1999-01-01 to 1 year ago
CINAHL Plus with Full Text (EBSCOhost)
from 2006-02-01 to 1 year ago
Medline Complete (EBSCOhost)
from 1999-02-01 to 1 year ago
Nursing & Allied Health Database (ProQuest)
from 1999-01-01 to 1 year ago
Health & Medicine (ProQuest)
from 1999-01-01 to 1 year ago
Family Health Database (ProQuest)
from 1999-01-01 to 1 year ago
Public Health Database (ProQuest)
from 1999-01-01 to 1 year ago
- MeSH
- Basal Metabolism MeSH
- Diabetes Mellitus, Experimental * metabolism MeSH
- Insulin metabolism MeSH
- Insulin Resistance * MeSH
- Liver metabolism MeSH
- Lipid Metabolism MeSH
- Mice, Inbred C57BL MeSH
- Mice MeSH
- Animals MeSH
- Check Tag
- Mice MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
PURPOSE: Fatty acid esters of hydroxy fatty acids (FAHFAs) are a large family of endogenous bioactive lipids. To date, most of the studied FAHFAs are branched regioisomers of Palmitic Acid Hydroxyl Stearic Acid (PAHSA) that were reported to possess anti-diabetic and anti-inflammatory activity in humans and rodents. Recently, we have demonstrated that 9-PAHPA or 9-OAHPA intake increased basal metabolism and enhanced insulin sensitivity in healthy control diet-fed mice but induced liver damage in some mice. The present work aims to explore whether a long-term intake of 9-PAHPA or 9-OAHPA may have similar effects in obesogenic diet-fed mice. METHODS: C57Bl6 mice were fed with a control or high fat-high sugar (HFHS) diets for 12 weeks. The HFHS diet was supplemented or not with 9-PAHPA or 9-OAHPA. Whole-body metabolism was explored. Glucose and lipid metabolism as well as mitochondrial activity and oxidative stress status were analyzed. RESULTS: As expected, the intake of HFHS diet led to obesity and lower insulin sensitivity with minor effects on liver parameters. The long-term intake of 9-PAHPA or 9-OAHPA modulated favorably the basal metabolism and improved insulin sensitivity as measured by insulin tolerance test. On the contrary to what we have reported previously in healthy mice, no marked effect for these FAHFAs was observed on liver metabolism of obese diabetic mice. CONCLUSION: This study indicates that both 9-PAHPA and 9-OAHPA may have interesting insulin-sensitizing effects in obese mice with lower insulin sensitivity.
Aix Marseille Univ INSERM INRAE C2VN Marseille France
DMEM INRAE Univ Montpellier Montpellier France
INSERM U1194 Network of Experimental Histology BioCampus CNRS UMS3426 Montpellier France
Institut Des Biomolécules Max Mousseron Université de Montpellier CNRS ENSCM Montpellier France
LNC UMR1231 INSERM Univ Bourgogne Franche Comté Agrosup Dijon LipSTIC LabEx Dijon France
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