• Something wrong with this record ?

Early kinetics of cardiac troponin in suspected acute myocardial infarction

M. Rubini Giménez, K. Wildi, D. Wussler, L. Koechlin, J. Boeddinghaus, T. Nestelberger, P. Badertscher, R. Sedlmayer, C. Puelacher, T. Zimmermann, J. du Fay de Lavallaz, P. Lopez-Ayala, K. Leu, K. Rentsch, Ò. Miró, B. López, FJ. Martín-Sánchez,...

. 2021 ; 74 (6) : 502-509. [pub] 20200522

Language xxx, English Country Spain

Document type Journal Article, Multicenter Study

Persistent link   https://www.medvik.cz/link/bmc21018541

INTRODUCTION AND OBJECTIVES: Release kinetics of high-sensitivity cardiac troponin (hs-cTn) T and I in patients with acute myocardial infarction (AMI) are incompletely understood. We aimed to assess whether hs-cTnT/I release in early AMI is near linear. METHODS: In a prospective diagnostic multicenter study the acute release of hs-cTnT and hs-cTnI within 1 and 2hours from presentation to the emergency department was quantified using 3 hs-cTnT/I assays in patients with suspected AMI. The primary endpoint was correlation between hs-cTn changes from presentation to 1 hour vs changes from presentation to 2hours, among all AMI patients and different prespecified subgroups. The final diagnosis was adjudicated by 2 independent cardiologists, based on serial hs-cTnT from the serial study blood samples and additional locally measured hs-cTn values. RESULTS: Among 2437 patients with complete hs-cTnT data, AMI was the adjudicated diagnosis in 376 patients (15%). For hs-cTnT, the correlation coefficient between 0- to 1-hour change and 0- to 2 hour change was 0.931 (95%CI, 0.916-0.944), P <.001. Similar findings were obtained with hs-cTnI (Architect) with correlation coefficients between 0- to 1-hour change and 0- to 2 hour change of 0.969 and hs-cTnI (Centaur) of 0.934 (P <.001 for both). Findings were consistent among type 1 and type 2 AMI and in the subgroup of patients presenting very early after chest pain onset. CONCLUSIONS: Patients presenting with early AMI showed a near linear release of hs-cTnT and hs-cTnI. This near linearity provides the pathophysiological basis for rapid diagnostic algorithms using 0- to 1-hour changes as surrogates for 0- to 2 hour or 0- to 3 hour changes. Registered at ClinicalTrials.gov (Identifier: NCT00470587).

References provided by Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc21018541
003      
CZ-PrNML
005      
20210830100125.0
007      
ta
008      
210728s2021 sp f 000 0|eng s
009      
AR
024    7_
$a 10.1016/j.rec.2020.04.008 $2 doi
035    __
$a (PubMed)32451223
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng spa
044    __
$a sp
100    1_
$a Rubini Giménez, María $u Department of Cardiology and Cardiovascular Research, Institute Basel (CRIB), University Hospital Basel, Basel, Switzerland; Department of Cardiology, Heart Center Leipzig, Leipzig, Germany
245    10
$a Early kinetics of cardiac troponin in suspected acute myocardial infarction / $c M. Rubini Giménez, K. Wildi, D. Wussler, L. Koechlin, J. Boeddinghaus, T. Nestelberger, P. Badertscher, R. Sedlmayer, C. Puelacher, T. Zimmermann, J. du Fay de Lavallaz, P. Lopez-Ayala, K. Leu, K. Rentsch, Ò. Miró, B. López, FJ. Martín-Sánchez, J. Bustamante, D. Kawecki, J. Parenica, J. Lohrmann, W. Kloos, A. Buser, DI. Keller, T. Reichlin, R. Twerenbold, C. Mueller
520    9_
$a INTRODUCTION AND OBJECTIVES: Release kinetics of high-sensitivity cardiac troponin (hs-cTn) T and I in patients with acute myocardial infarction (AMI) are incompletely understood. We aimed to assess whether hs-cTnT/I release in early AMI is near linear. METHODS: In a prospective diagnostic multicenter study the acute release of hs-cTnT and hs-cTnI within 1 and 2hours from presentation to the emergency department was quantified using 3 hs-cTnT/I assays in patients with suspected AMI. The primary endpoint was correlation between hs-cTn changes from presentation to 1 hour vs changes from presentation to 2hours, among all AMI patients and different prespecified subgroups. The final diagnosis was adjudicated by 2 independent cardiologists, based on serial hs-cTnT from the serial study blood samples and additional locally measured hs-cTn values. RESULTS: Among 2437 patients with complete hs-cTnT data, AMI was the adjudicated diagnosis in 376 patients (15%). For hs-cTnT, the correlation coefficient between 0- to 1-hour change and 0- to 2 hour change was 0.931 (95%CI, 0.916-0.944), P <.001. Similar findings were obtained with hs-cTnI (Architect) with correlation coefficients between 0- to 1-hour change and 0- to 2 hour change of 0.969 and hs-cTnI (Centaur) of 0.934 (P <.001 for both). Findings were consistent among type 1 and type 2 AMI and in the subgroup of patients presenting very early after chest pain onset. CONCLUSIONS: Patients presenting with early AMI showed a near linear release of hs-cTnT and hs-cTnI. This near linearity provides the pathophysiological basis for rapid diagnostic algorithms using 0- to 1-hour changes as surrogates for 0- to 2 hour or 0- to 3 hour changes. Registered at ClinicalTrials.gov (Identifier: NCT00470587).
650    _2
$a biologické markery $7 D015415
650    _2
$a lidé $7 D006801
650    _2
$a kinetika $7 D007700
650    12
$a infarkt myokardu $x diagnóza $7 D009203
650    _2
$a prospektivní studie $7 D011446
650    _2
$a troponin I $7 D019210
650    12
$a troponin T $7 D020107
655    _2
$a časopisecké články $7 D016428
655    _2
$a multicentrická studie $7 D016448
700    1_
$a Wildi, Karin $u Department of Cardiology and Cardiovascular Research, Institute Basel (CRIB), University Hospital Basel, Basel, Switzerland; Critical Care Research Institute, the Prince Charles Hospital, Brisbane and University of Queensland, Brisbane, Australia
700    1_
$a Wussler, Desiree $u Department of Cardiology and Cardiovascular Research, Institute Basel (CRIB), University Hospital Basel, Basel, Switzerland; Department of Internal Medicine, University Hospital Basel, Basel, Switzerland
700    1_
$a Koechlin, Luca $u Department of Cardiology and Cardiovascular Research, Institute Basel (CRIB), University Hospital Basel, Basel, Switzerland; Department of Heart Surgery, University Hospital Basel, Basel, Switzerland
700    1_
$a Boeddinghaus, Jasper $u Department of Cardiology and Cardiovascular Research, Institute Basel (CRIB), University Hospital Basel, Basel, Switzerland; Department of Internal Medicine, University Hospital Basel, Basel, Switzerland
700    1_
$a Nestelberger, Thomas $u Department of Cardiology and Cardiovascular Research, Institute Basel (CRIB), University Hospital Basel, Basel, Switzerland
700    1_
$a Badertscher, Patrick $u Department of Cardiology and Cardiovascular Research, Institute Basel (CRIB), University Hospital Basel, Basel, Switzerland; Department of Cardiology, University of Illinois at Chicago, Chicago, United States
700    1_
$a Sedlmayer, Raphael $u Department of Cardiology and Cardiovascular Research, Institute Basel (CRIB), University Hospital Basel, Basel, Switzerland
700    1_
$a Puelacher, Christian $u Department of Cardiology and Cardiovascular Research, Institute Basel (CRIB), University Hospital Basel, Basel, Switzerland; Department of Internal Medicine, University Hospital Basel, Basel, Switzerland
700    1_
$a Zimmermann, Tobias $u Department of Cardiology and Cardiovascular Research, Institute Basel (CRIB), University Hospital Basel, Basel, Switzerland
700    1_
$a du Fay de Lavallaz, Jeanne $u Department of Cardiology and Cardiovascular Research, Institute Basel (CRIB), University Hospital Basel, Basel, Switzerland; Department of Internal Medicine, University Hospital Basel, Basel, Switzerland
700    1_
$a Lopez-Ayala, Pedro $u Department of Cardiology and Cardiovascular Research, Institute Basel (CRIB), University Hospital Basel, Basel, Switzerland; Department of Internal Medicine, University Hospital Basel, Basel, Switzerland
700    1_
$a Leu, Kathrin $u Department of Cardiology and Cardiovascular Research, Institute Basel (CRIB), University Hospital Basel, Basel, Switzerland
700    1_
$a Rentsch, Katharina $u Laboratory Medicine, University Hospital Basel, Basel, Switzerland
700    1_
$a Miró, Òscar $u Servicio de Urgencias, Hospital Clínic, Barcelona, Spain
700    1_
$a López, Beatriz $u Servicio de Urgencias, Hospital Clínic, Barcelona, Spain
700    1_
$a Martín-Sánchez, F Javier $u Servicio de Urgencias, Hospital Clínico San Carlos, Madrid, Spain
700    1_
$a Bustamante, José $u Servicio de Urgencias, Hospital Clínico San Carlos, Madrid, Spain
700    1_
$a Kawecki, Damian $u 2nd Department of Cardiology, Medical University of Silesia, Zabrze, Poland
700    1_
$a Parenica, Jiri $u Department of Cardiology, University Hospital Brno, Brno, Czech Republic and Medical Faculty, Masaryk University, Brno, Czech Republic
700    1_
$a Lohrmann, Jens $u Department of Cardiology and Cardiovascular Research, Institute Basel (CRIB), University Hospital Basel, Basel, Switzerland; Emergency Department, University Hospital Basel, Basel, Switzerland
700    1_
$a Kloos, Wanda $u Department of Cardiology and Cardiovascular Research, Institute Basel (CRIB), University Hospital Basel, Basel, Switzerland; Emergency Department, University Hospital Basel, Basel, Switzerland
700    1_
$a Buser, Andreas $u Blood Transfusion Centre, Swiss Red Cross, Basel, Switzerland and Department of Hematology, University Hospital Basel, Basel, Switzerland
700    1_
$a Keller, Dagmar I $u Emergency Department, University Hospital Zurich, Zurich, Switzerland
700    1_
$a Reichlin, Tobias $u Department of Cardiology and Cardiovascular Research, Institute Basel (CRIB), University Hospital Basel, Basel, Switzerland; Department of Department, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland
700    1_
$a Twerenbold, Raphael $u Department of Cardiology and Cardiovascular Research, Institute Basel (CRIB), University Hospital Basel, Basel, Switzerland
700    1_
$a Mueller, Christian $u Department of Cardiology and Cardiovascular Research, Institute Basel (CRIB), University Hospital Basel, Basel, Switzerland. Electronic address: Christian.Mueller@usb.ch
773    0_
$w MED00167446 $t Revista espanola de cardiologia (English ed.) $x 1885-5857 $g Roč. 74, č. 6 (2021), s. 502-509
856    41
$u https://pubmed.ncbi.nlm.nih.gov/32451223 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y p $z 0
990    __
$a 20210728 $b ABA008
991    __
$a 20210830100125 $b ABA008
999    __
$a ok $b bmc $g 1689589 $s 1138987
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2021 $b 74 $c 6 $d 502-509 $e 20200522 $i 1885-5857 $m Revista española de cardiología $n Rev Esp Cardiol $x MED00167446
LZP    __
$a Pubmed-20210728

Find record

Citation metrics

Archiving options