-
Something wrong with this record ?
Gonadectomy in conditions affecting sex development: a registry-based cohort study
AK. Lucas-Herald, J. Bryce, A. Kyriakou, ML. Ljubicic, W. Arlt, L. Audi, A. Balsamo, F. Baronio, S. Bertelloni, M. Bettendorf, A. Brooke, HL. Claahsen van der Grinten, JH. Davies, G. Hermann, L. de Vries, IA. Hughes, R. Tadokoro-Cuccaro, F....
Language English Country Great Britain
Document type Journal Article
NLK
Open Access Digital Library
from 1948-06-01
Open Access Digital Library
from 1997-07-01
PubMed
33780351
DOI
10.1530/eje-20-1058
Knihovny.cz E-resources
- MeSH
- Adult MeSH
- Castration statistics & numerical data MeSH
- Middle Aged MeSH
- Humans MeSH
- Adolescent MeSH
- Young Adult MeSH
- Disorders of Sex Development diagnosis epidemiology surgery MeSH
- Registries MeSH
- Retrospective Studies MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Adolescent MeSH
- Young Adult MeSH
- Male MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
Objectives: To determine trends in clinical practice for individuals with DSD requiring gonadectomy. Design: Retrospective cohort study. Methods: Information regarding age at gonadectomy according to diagnosis; reported sex; time of presentation to specialist centre; and location of centre from cases reported to the International DSD Registry and who were over 16 years old in January 2019. Results: Data regarding gonadectomy were available in 668 (88%) individuals from 44 centres. Of these, 248 (37%) (median age (range) 24 (17, 75) years) were male and 420 (63%) (median age (range) 26 (16, 86) years) were female. Gonadectomy was reported from 36 centres in 351/668 cases (53%). Females were more likely to undergo gonadectomy (n = 311, P < 0.0001). The indication for gonadectomy was reported in 268 (76%). The most common indication was mitigation of tumour risk in 172 (64%). Variations in the practice of gonadectomy were observed; of the 351 cases from 36 centres, 17 (5%) at 9 centres had undergone gonadectomy before their first presentation to the specialist centre. Median age at gonadectomy of cases from high-income countries and low-/middle-income countries (LMIC) was 13.0 years (0.1, 68) years and 16.5 years (1, 28), respectively (P < 0.0001) with the likelihood of long-term retention of gonads being higher in LMIC countries. Conclusions: The likelihood of gonadectomy depends on the underlying diagnosis, sex of rearing and the geographical setting. Clinical benchmarks, which can be studied across all forms of DSD will allow a better understanding of the variation in the practice of gonadectomy.
Centre for Prenatal Diagnosis Jilin University 1st Hospital Jilin China
Department of Clinical Genetics National Research Centre Cairo Egypt
Department of Endocrinology St Albans City Hospital West Hertfordshire Hospitals Trust St Albans UK
Department of Growth and Reproduction Rigshospitalet University of Copenhagen Copenhagen Denmark
Department of Paediatric Endocrinology Faculty of Medicine University of Southampton Southampton UK
Department of Paediatric Endocrinology Royal Manchester Children's Hospital Manchester UK
Department of Paediatrics University of Cambridge Cambridge UK
Department of Pediatric Endocrinology Istanbul University Istanbul Medical School Istanbul Turkey
Department of Pediatric Endocrinology Marmara University Istanbul Turkey
Department of Pediatrics and Adolescent Medicine University Medical Centre Ulm Germany
Department of Pediatrics and Pediatric Endocrinology Medical University of Silesia Katowice Poland
Department of Pediatrics Leiden University Medical Center Leiden the Netherlands
Department of Pediatrics Otto von Guericke University Magdeburg Germany
Department of Pediatrics Radboud University Medical Center Nijmegen the Netherlands
Department of Pediatrics University Hospital Pisa Pisa Italy
Dept of Women's and Children's Health Karolinska Institutet Stockholm Sweden
Developmental Endocrinology Research Group University of Glasgow Glasgow UK
Division of Paediatrics University of Lübeck Lübeck Germany
Endocrinology Birmingham Children's Hospital Birmingham UK
Endocrinology Institute of Prague Czech Republic
Endocrinology University of Medicine and Pharmacy Craiova Craiova Romania
Endocrinology Yerevan State Medical University Endocrinology Clinic Yerevan Armenia
Faculty of Medical Laboratory Sciences Al Neelain University Khartoum Sudan
Institute of Metabolism and Systems Research University of Birmingham Birmingham UK
Macleod Diabetes and Endocrine Centre Royal Devon and Exeter Hospital Exeter UK
Paediatrics Tel Aviv Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel
Pediatric Endocrinology Clinic Zeynep Kamil Women and Children Hospital Istanbul Turkey
Pediatric Endocrinology Dana Dwek Children's Hospital Tel Aviv Medical Centre Tel Aviv Israel
Pediatric Endocrinology Service University Hospital Ghent Ghent Belgium
UMHAT 'Sveta Marina' Medical University of Varna Varna Bulgaria
References provided by Crossref.org
- 000
- 00000naa a2200000 a 4500
- 001
- bmc21018637
- 003
- CZ-PrNML
- 005
- 20210830100234.0
- 007
- ta
- 008
- 210728s2021 xxk f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.1530/EJE-20-1058 $2 doi
- 035 __
- $a (PubMed)33780351
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a xxk
- 100 1_
- $a Lucas-Herald, Angela K $u Developmental Endocrinology Research Group, University of Glasgow, Glasgow, UK
- 245 10
- $a Gonadectomy in conditions affecting sex development: a registry-based cohort study / $c AK. Lucas-Herald, J. Bryce, A. Kyriakou, ML. Ljubicic, W. Arlt, L. Audi, A. Balsamo, F. Baronio, S. Bertelloni, M. Bettendorf, A. Brooke, HL. Claahsen van der Grinten, JH. Davies, G. Hermann, L. de Vries, IA. Hughes, R. Tadokoro-Cuccaro, F. Darendeliler, S. Poyrazoglu, M. Ellaithi, O. Evliyaoglu, S. Fica, L. Nedelea, A. Gawlik, E. Globa, N. Zelinska, T. Guran, A. Güven, SE. Hannema, O. Hiort, PM. Holterhus, V. Iotova, V. Mladenov, V. Jain, R. Sharma, F. Jennane, C. Johnston, G. Guerra Junior, D. Konrad, O. Gaisl, N. Krone, R. Krone, K. Lachlan, D. Li, C. Lichiardopol, L. Lisa, R. Markosyan, I. Mazen, K. Mohnike, M. Niedziela, A. Nordenstrom, R. Rey, M. Skaeil, LJW. Tack, J. Tomlinson, N. Weintrob, M. Cools, SF. Ahmed
- 520 9_
- $a Objectives: To determine trends in clinical practice for individuals with DSD requiring gonadectomy. Design: Retrospective cohort study. Methods: Information regarding age at gonadectomy according to diagnosis; reported sex; time of presentation to specialist centre; and location of centre from cases reported to the International DSD Registry and who were over 16 years old in January 2019. Results: Data regarding gonadectomy were available in 668 (88%) individuals from 44 centres. Of these, 248 (37%) (median age (range) 24 (17, 75) years) were male and 420 (63%) (median age (range) 26 (16, 86) years) were female. Gonadectomy was reported from 36 centres in 351/668 cases (53%). Females were more likely to undergo gonadectomy (n = 311, P < 0.0001). The indication for gonadectomy was reported in 268 (76%). The most common indication was mitigation of tumour risk in 172 (64%). Variations in the practice of gonadectomy were observed; of the 351 cases from 36 centres, 17 (5%) at 9 centres had undergone gonadectomy before their first presentation to the specialist centre. Median age at gonadectomy of cases from high-income countries and low-/middle-income countries (LMIC) was 13.0 years (0.1, 68) years and 16.5 years (1, 28), respectively (P < 0.0001) with the likelihood of long-term retention of gonads being higher in LMIC countries. Conclusions: The likelihood of gonadectomy depends on the underlying diagnosis, sex of rearing and the geographical setting. Clinical benchmarks, which can be studied across all forms of DSD will allow a better understanding of the variation in the practice of gonadectomy.
- 650 _2
- $a mladiství $7 D000293
- 650 _2
- $a dospělí $7 D000328
- 650 _2
- $a senioři $7 D000368
- 650 _2
- $a senioři nad 80 let $7 D000369
- 650 _2
- $a kastrace $x statistika a číselné údaje $7 D002369
- 650 _2
- $a poruchy sexuálního vývoje $x diagnóza $x epidemiologie $x chirurgie $7 D012734
- 650 _2
- $a ženské pohlaví $7 D005260
- 650 _2
- $a lidé $7 D006801
- 650 _2
- $a mužské pohlaví $7 D008297
- 650 _2
- $a lidé středního věku $7 D008875
- 650 _2
- $a registrace $7 D012042
- 650 _2
- $a retrospektivní studie $7 D012189
- 650 _2
- $a mladý dospělý $7 D055815
- 655 _2
- $a časopisecké články $7 D016428
- 700 1_
- $a Bryce, Jillian $u Developmental Endocrinology Research Group, University of Glasgow, Glasgow, UK
- 700 1_
- $a Kyriakou, Andreas $u Developmental Endocrinology Research Group, University of Glasgow, Glasgow, UK
- 700 1_
- $a Ljubicic, Marie Lindhardt $u Department of Growth and Reproduction, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
- 700 1_
- $a Arlt, Wiebke $u Institute of Metabolism and Systems Research (IMSR), University of Birmingham, Birmingham, UK $u Centre for Endocrinology, Diabetes and Metabolism, University Hospital Birmingham NHS Foundation Trust, Birmingham, UK
- 700 1_
- $a Audi, Laura $u Department of Pediatrics and Pediatric Endocrinology Unit, Vall d'Hebron Research Institute (VHIR), Hospital Vall d'Hebron, Barcelona, Spain
- 700 1_
- $a Balsamo, Antonio $u Department of Pediatrics, University of Bologna Hospital of Bologna Sant Orsola-Malpighi, Bologna, Italy
- 700 1_
- $a Baronio, Federico $u Department of Pediatrics, University of Bologna Hospital of Bologna Sant Orsola-Malpighi, Bologna, Italy
- 700 1_
- $a Bertelloni, Silvano $u Department of Pediatrics, University Hospital Pisa, Pisa, Italy
- 700 1_
- $a Bettendorf, Markus $u Division of Paediatric Endocrinology and Diabetes, Department of Paediatrics, University Hospital Heidelberg, Heidelberg, Germany
- 700 1_
- $a Brooke, Antonia $u Macleod Diabetes and Endocrine Centre, Royal Devon and Exeter Hospital, Exeter, UK
- 700 1_
- $a Claahsen van der Grinten, Hedi L $u Department of Pediatrics, Radboud University Medical Center, Nijmegen, the Netherlands
- 700 1_
- $a Davies, Justin H $u Department of Paediatric Endocrinology, Faculty of Medicine, University of Southampton, Southampton, UK
- 700 1_
- $a Hermann, Gloria $u Department of Pediatrics and Adolescent Medicine, University Medical Centre, Ulm, Germany
- 700 1_
- $a de Vries, Liat $u Paediatrics, Tel Aviv Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel $u Jesse Z and Sara Lea Shafer Institute for Endocrinology and Diabetes, Schneider Children's Medical Centre of Israel, Petah Tikvah, Israel
- 700 1_
- $a Hughes, Ieuan A $u Department of Paediatrics, University of Cambridge, Cambridge, UK
- 700 1_
- $a Tadokoro-Cuccaro, Rieko $u Department of Paediatrics, University of Cambridge, Cambridge, UK
- 700 1_
- $a Darendeliler, Feyza $u Department of Pediatric Endocrinology, Istanbul University, Istanbul Medical School, Istanbul, Turkey
- 700 1_
- $a Poyrazoglu, Sukran $u Department of Pediatric Endocrinology, Istanbul University, Istanbul Medical School, Istanbul, Turkey
- 700 1_
- $a Ellaithi, Mona $u Faculty of Medical Laboratory Sciences, Al-Neelain University, Khartoum, Sudan
- 700 1_
- $a Evliyaoglu, Olcay $u Department of Pediatric Endocrinology, Istanbul University - Cerrahpasa, Cerrahpaşa Medical School, Istanbul, Turkey
- 700 1_
- $a Fica, Simone $u Endocrinologie, Universitatea de Medicina si Farmacie Carol Davila Facultatea de Medicine, Bucharest, Romania
- 700 1_
- $a Nedelea, Lavinia $u Endocrinologie, Universitatea de Medicina si Farmacie Carol Davila Facultatea de Medicine, Bucharest, Romania
- 700 1_
- $a Gawlik, Aneta $u Department of Pediatrics and Pediatric Endocrinology, Medical University of Silesia, Katowice, Poland
- 700 1_
- $a Globa, Evgenia $u Ukrainian Research Center of Endocrine Surgery, Endocrine Organs and Tissue Transplantation, MOH of Ukraine, Kyiv, Ukraine
- 700 1_
- $a Zelinska, Nataliya $u Ukrainian Research Center of Endocrine Surgery, Endocrine Organs and Tissue Transplantation, MOH of Ukraine, Kyiv, Ukraine
- 700 1_
- $a Guran, Tulay $u Department of Pediatric Endocrinology, Marmara University, Istanbul, Turkey
- 700 1_
- $a Güven, Ayla $u Pediatric Endocrinology Clinic, Zeynep Kamil Women and Children Hospital, Istanbul, Turkey
- 700 1_
- $a Hannema, Sabine E $u Pediatric Endocrinology, Erasmus Medical Centre, University Medical Centre Rotterdam, Rotterdam, the Netherlands $u Department of Pediatrics, Leiden University Medical Center, Leiden, the Netherlands
- 700 1_
- $a Hiort, Olaf $u Division of Paediatrics, University of Lübeck, Lübeck, Germany
- 700 1_
- $a Holterhus, Paul-Martin $u Division of Pediatric Endocrinology and Diabetes, Department of Pediatrics, University Hospital of Schleswig-Holstein Campus Kiel/Christian-Albrechts-University of Kiel, Kiel, Germany
- 700 1_
- $a Iotova, Violeta $u UMHAT 'Sveta Marina', Medical University of Varna, Varna, Bulgaria
- 700 1_
- $a Mladenov, Vilhelm $u UMHAT 'Sveta Marina', Medical University of Varna, Varna, Bulgaria
- 700 1_
- $a Jain, Vandana $u Division of Pediatric Endocrinology, Department of Pediatrics, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India
- 700 1_
- $a Sharma, Rajni $u Division of Pediatric Endocrinology, Department of Pediatrics, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India
- 700 1_
- $a Jennane, Farida $u Unité d'Endocrinologie/Diabétologie et Gynécologie de l'Enfant et de l'Adolescent, Hôpital d'Enfants, Casablanca, Morocco
- 700 1_
- $a Johnston, Colin $u Department of Endocrinology, St Albans City Hospital, West Hertfordshire Hospitals Trust, St Albans, UK
- 700 1_
- $a Guerra Junior, Gil $u Disciplina de Endocrinologia e Metabologia, Faculdade deo Ciencias Medicas da Universidade de Campinas, Departamento de Pediatria e Departamento de Clinica Medica, Sao Paolo, Brazil
- 700 1_
- $a Konrad, Daniel $u Division of Pediatric Endocrinology and Diabetology and Children's Research Center, University Children's Hospital, Zürich, Switzerland
- 700 1_
- $a Gaisl, Odile $u Division of Pediatric Endocrinology and Diabetology and Children's Research Center, University Children's Hospital, Zürich, Switzerland
- 700 1_
- $a Krone, Nils $u Department of Oncology and Metabolism, Academic Unit of Child Health, University of Sheffield, Sheffield, UK
- 700 1_
- $a Krone, Ruth $u Endocrinology, Birmingham Children's Hospital, Birmingham, UK
- 700 1_
- $a Lachlan, Katherine $u Department of Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, UK
- 700 1_
- $a Li, Dejun $u Centre for Prenatal Diagnosis, Jilin University First Hospital, Jilin, China
- 700 1_
- $a Lichiardopol, Corina $u Endocrinology, University of Medicine and Pharmacy Craiova, Craiova, Romania
- 700 1_
- $a Lisa, Lidka $u Endocrinology, Institute of Prague, Czech Republic
- 700 1_
- $a Markosyan, Renata $u Endocrinology, Yerevan State Medical University Endocrinology Clinic, Yerevan, Armenia
- 700 1_
- $a Mazen, Inas $u Department of Clinical Genetics, National Research Centre, Cairo, Egypt
- 700 1_
- $a Mohnike, Klaus $u Department of Pediatrics, Otto-von-Guericke University, Magdeburg, Germany
- 700 1_
- $a Niedziela, Marek $u Department of Pediatric Endocrinology, Poznan University of Medical Sciences, Poznan, Wielkopolskie, Poland
- 700 1_
- $a Nordenstrom, Anna $u Dept of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden
- 700 1_
- $a Rey, Rodolfo $u CONICET - FEI - División de Endocrinología, Centro de Investigaciones Endocrinológicas 'Dr. César Bergadá' (CEDIE), Buenos Aires, Argentina
- 700 1_
- $a Skaeil, Mars $u Department of Paediatric Endocrinology, Royal Manchester Children's Hospital, Manchester, UK
- 700 1_
- $a Tack, Lloyd J W $u Pediatric Endocrinology Service, University Hospital Ghent, Ghent, Belgium
- 700 1_
- $a Tomlinson, Jeremy $u Oxford Centre for Diabetes, Endocrinology & Metabolism, NIHR Oxford Biomedical Research Centre, Churchill Hospital, University of Oxford, Oxford, UK
- 700 1_
- $a Weintrob, Naomi $u Paediatrics, Tel Aviv Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel $u Pediatric Endocrinology, Dana Dwek Children's Hospital, Tel Aviv Medical Centre, Tel Aviv, Israel
- 700 1_
- $a Cools, Martine $u Pediatric Endocrinology Service, University Hospital Ghent, Ghent, Belgium
- 700 1_
- $a Ahmed, S Faisal $u Developmental Endocrinology Research Group, University of Glasgow, Glasgow, UK
- 773 0_
- $w MED00009634 $t European journal of endocrinology $x 1479-683X $g Roč. 184, č. 6 (2021), s. 791-801
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/33780351 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y p $z 0
- 990 __
- $a 20210728 $b ABA008
- 991 __
- $a 20210830100234 $b ABA008
- 999 __
- $a ok $b bmc $g 1689664 $s 1139083
- BAS __
- $a 3
- BAS __
- $a PreBMC
- BMC __
- $a 2021 $b 184 $c 6 $d 791-801 $e 20210504 $i 1479-683X $m European journal of endocrinology $n Eur J Endocrinol $x MED00009634
- LZP __
- $a Pubmed-20210728
