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Serotonin-Its Synthesis and Roles in the Healthy and the Critically Ill
M. Kanova, P. Kohout
Language English Country Switzerland
Document type Journal Article, Review
NLK
Free Medical Journals
from 2000
Freely Accessible Science Journals
from 2000
PubMed Central
from 2007
Europe PubMed Central
from 2007
ProQuest Central
from 2000-03-01
Open Access Digital Library
from 2000-01-01
Open Access Digital Library
from 2007-01-01
Health & Medicine (ProQuest)
from 2000-03-01
ROAD: Directory of Open Access Scholarly Resources
from 2000
PubMed
34063611
DOI
10.3390/ijms22094837
Knihovny.cz E-resources
- MeSH
- Central Nervous System metabolism pathology MeSH
- Delirium metabolism pathology MeSH
- Gastrointestinal Motility physiology MeSH
- Gastrointestinal Tract metabolism pathology MeSH
- Blood-Brain Barrier metabolism pathology MeSH
- Critical Illness * MeSH
- Humans MeSH
- Myoclonus metabolism pathology MeSH
- Serotonin biosynthesis metabolism MeSH
- Serotonin Syndrome metabolism pathology MeSH
- Inflammation metabolism pathology MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Review MeSH
Serotonin (5-hydroxytryptamine, 5-HT) plays two important roles in humans-one central and the other peripheral-depending on the location of the 5-HT pools of on either side of the blood-brain barrier. In the central nervous system it acts as a neurotransmitter, controlling such brain functions as autonomic neural activity, stress response, body temperature, sleep, mood and appetite. This role is very important in intensive care, as in critically ill patients multiple serotoninergic agents like opioids, antiemetics and antidepressants are frequently used. High serotonin levels lead to altered mental status, deliria, rigidity and myoclonus, together recognized as serotonin syndrome. In its role as a peripheral hormone, serotonin is unique in controlling the functions of several organs. In the gastrointestinal tract it is important for regulating motor and secretory functions. Apart from intestinal motility, energy metabolism is regulated by both central and peripheral serotonin signaling. It also has fundamental effects on hemostasis, vascular tone, heart rate, respiratory drive, cell growth and immunity. Serotonin regulates almost all immune cells in response to inflammation, following the activation of platelets.
References provided by Crossref.org
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