-
Je něco špatně v tomto záznamu ?
Parechovirus Infection in Early Childhood and Association With Subsequent Celiac Disease
G. Tapia, K. Chudá, CR. Kahrs, LC. Stene, L. Kramna, K. Mårild, T. Rasmussen, KS. Rønningen, O. Cinek, K. Størdal
Jazyk angličtina Země Spojené státy americké
Typ dokumentu časopisecké články, práce podpořená grantem
NLK
ProQuest Central
od 2020-01-01 do Před 1 rokem
Health & Medicine (ProQuest)
od 2020-01-01 do Před 1 rokem
- MeSH
- autoimunita * MeSH
- autoprotilátky krev MeSH
- celiakie diagnóza imunologie virologie MeSH
- dítě MeSH
- kojenec MeSH
- lidé MeSH
- následné studie MeSH
- Parechovirus imunologie MeSH
- pikornavirové infekce diagnóza imunologie virologie MeSH
- předškolní dítě MeSH
- protilátky virové imunologie MeSH
- rizikové faktory MeSH
- studie případů a kontrol MeSH
- věkové faktory MeSH
- Check Tag
- dítě MeSH
- kojenec MeSH
- lidé MeSH
- mužské pohlaví MeSH
- předškolní dítě MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
INTRODUCTION: To test whether parechovirus and anellovirus, frequent enteric viruses, were associated with subsequent celiac disease (CD). We hypothesized that children who later developed CD would have increased frequency of parechovirus infections before transglutaminase 2 (TG2) antibody development. Anellovirus testing was exploratory, as a potential marker of immune status. METHODS: Matched case-control design nested within a longitudinal birth cohort (the MIDIA study) of children at genetic risk of CD (carrying the human leukocyte antigen genotype DR4-DQ8/DR3-DQ2, recruited throughout Norway during 2001-2007). We retrospectively tested blood samples taken at age 3, 6, 9, and 12 months, and then annually, to determine when TG2 antibodies developed. Of 220 genetically at-risk children tested, 25 were diagnosed with CD (cases; ESPGHAN 2012 criteria) and matched for follow-up time, birthdate, and county of residence with 2 randomly selected children free from CD (controls) from the cohort. Viruses were quantified in monthly stool samples (collected from 3 through 35 months of age) using real-time polymerase chain reaction methods. RESULTS: Parechovirus was detected in 222 of 2,005 stool samples (11.1%) and was more frequent in samples from cases before developing TG2 antibodies (adjusted odds ratio 1.67, 95% confidence interval 1.14-2.45, P = 0.01). The odds ratio was higher when a sample was positive for both parechovirus and enterovirus (adjusted odds ratio 4.73, 95% confidence interval 1.26-17.67, P = 0.02). Anellovirus was detected in 1,540 of 1,829 samples (84.2%), but did not differ significantly between case and control subjects. DISCUSSION: Early-life parechovirus infections were associated with development of CD in genetically at-risk children.
Department of Chronic Diseases and Ageing Norwegian Institute of Public Health Oslo Norway
Department of Pediatric Research Oslo University Hospital Oslo Norway
Department of Pediatrics Østfold Hospital Trust Grålum Norway
Citace poskytuje Crossref.org
- 000
- 00000naa a2200000 a 4500
- 001
- bmc21018882
- 003
- CZ-PrNML
- 005
- 20210830100451.0
- 007
- ta
- 008
- 210728s2021 xxu f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.14309/ajg.0000000000001003 $2 doi
- 035 __
- $a (PubMed)33982949
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a xxu
- 100 1_
- $a Tapia, German $u 1Department of Chronic Diseases and Ageing, Norwegian Institute of Public Health, Oslo, Norway; 2Department of Paediatric, 2nd Faculty of Medicine, Charles University in Prague and University Hospital Motol, Prague, Czech Republic; 3Department of Pediatrics, Østfold Hospital Trust, Grålum, Norway; 4Department of Pediatrics, Institute of Clinical Sciences, The Sahlgrenska Academy at University of Gothenburg and Queen Silvia Children's Hospital, Gothenburg, Sweden; 5Division of Institute Resources, Department of IT and e-health, Norwegian Institute of Public Health, Oslo, Norway; 6Department of Pediatric Research, Oslo University Hospital, Oslo, Norway
- 245 10
- $a Parechovirus Infection in Early Childhood and Association With Subsequent Celiac Disease / $c G. Tapia, K. Chudá, CR. Kahrs, LC. Stene, L. Kramna, K. Mårild, T. Rasmussen, KS. Rønningen, O. Cinek, K. Størdal
- 520 9_
- $a INTRODUCTION: To test whether parechovirus and anellovirus, frequent enteric viruses, were associated with subsequent celiac disease (CD). We hypothesized that children who later developed CD would have increased frequency of parechovirus infections before transglutaminase 2 (TG2) antibody development. Anellovirus testing was exploratory, as a potential marker of immune status. METHODS: Matched case-control design nested within a longitudinal birth cohort (the MIDIA study) of children at genetic risk of CD (carrying the human leukocyte antigen genotype DR4-DQ8/DR3-DQ2, recruited throughout Norway during 2001-2007). We retrospectively tested blood samples taken at age 3, 6, 9, and 12 months, and then annually, to determine when TG2 antibodies developed. Of 220 genetically at-risk children tested, 25 were diagnosed with CD (cases; ESPGHAN 2012 criteria) and matched for follow-up time, birthdate, and county of residence with 2 randomly selected children free from CD (controls) from the cohort. Viruses were quantified in monthly stool samples (collected from 3 through 35 months of age) using real-time polymerase chain reaction methods. RESULTS: Parechovirus was detected in 222 of 2,005 stool samples (11.1%) and was more frequent in samples from cases before developing TG2 antibodies (adjusted odds ratio 1.67, 95% confidence interval 1.14-2.45, P = 0.01). The odds ratio was higher when a sample was positive for both parechovirus and enterovirus (adjusted odds ratio 4.73, 95% confidence interval 1.26-17.67, P = 0.02). Anellovirus was detected in 1,540 of 1,829 samples (84.2%), but did not differ significantly between case and control subjects. DISCUSSION: Early-life parechovirus infections were associated with development of CD in genetically at-risk children.
- 650 _2
- $a věkové faktory $7 D000367
- 650 _2
- $a protilátky virové $x imunologie $7 D000914
- 650 _2
- $a autoprotilátky $x krev $7 D001323
- 650 12
- $a autoimunita $7 D015551
- 650 _2
- $a studie případů a kontrol $7 D016022
- 650 _2
- $a celiakie $x diagnóza $x imunologie $x virologie $7 D002446
- 650 _2
- $a dítě $7 D002648
- 650 _2
- $a předškolní dítě $7 D002675
- 650 _2
- $a ženské pohlaví $7 D005260
- 650 _2
- $a následné studie $7 D005500
- 650 _2
- $a lidé $7 D006801
- 650 _2
- $a kojenec $7 D007223
- 650 _2
- $a mužské pohlaví $7 D008297
- 650 _2
- $a Parechovirus $x imunologie $7 D030061
- 650 _2
- $a pikornavirové infekce $x diagnóza $x imunologie $x virologie $7 D010850
- 650 _2
- $a rizikové faktory $7 D012307
- 655 _2
- $a časopisecké články $7 D016428
- 655 _2
- $a práce podpořená grantem $7 D013485
- 700 1_
- $a Chudá, Kateřina
- 700 1_
- $a Kahrs, Christian R
- 700 1_
- $a Stene, Lars C
- 700 1_
- $a Kramna, Lenka
- 700 1_
- $a Mårild, Karl
- 700 1_
- $a Rasmussen, Trond
- 700 1_
- $a Rønningen, Kjersti S
- 700 1_
- $a Cinek, Ondřej
- 700 1_
- $a Størdal, Ketil
- 773 0_
- $w MED00000249 $t The American journal of gastroenterology $x 1572-0241 $g Roč. 116, č. 4 (2021), s. 788-795
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/33982949 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y p $z 0
- 990 __
- $a 20210728 $b ABA008
- 991 __
- $a 20210830100451 $b ABA008
- 999 __
- $a ok $b bmc $g 1689847 $s 1139328
- BAS __
- $a 3
- BAS __
- $a PreBMC
- BMC __
- $a 2021 $b 116 $c 4 $d 788-795 $e - $i 1572-0241 $m The American journal of gastroenterology $n Am J Gastroenterol $x MED00000249
- LZP __
- $a Pubmed-20210728
