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The transcriptional landscape of Shh medulloblastoma
P. Skowron, H. Farooq, FMG. Cavalli, AS. Morrissy, M. Ly, LD. Hendrikse, EY. Wang, H. Djambazian, H. Zhu, KL. Mungall, QM. Trinh, T. Zheng, S. Dai, ASG. Stucklin, MC. Vladoiu, V. Fong, BL. Holgado, C. Nor, X. Wu, D. Abd-Rabbo, P. Bérubé, YC....
Jazyk angličtina Země Velká Británie
Typ dokumentu časopisecké články, Research Support, N.I.H., Extramural, práce podpořená grantem
Grantová podpora
T32 CA151022
NCI NIH HHS - United States
P41 GM103504
NIGMS NIH HHS - United States
CIHR - Canada
R01 CA148699
NCI NIH HHS - United States
HHSN261200800001C
CCR NIH HHS - United States
R01 NS106155
NINDS NIH HHS - United States
R01 CA159859
NCI NIH HHS - United States
HHSN268201000029C
NHLBI NIH HHS - United States
Cancer Research UK - United Kingdom
HHSN261200800001E
NCI NIH HHS - United States
NLK
Directory of Open Access Journals
od 2015
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od 2010
Nature Open Access
od 2010-12-01
PubMed Central
od 2012
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od 2012
ProQuest Central
od 2010-01-01
Open Access Digital Library
od 2015-01-01
Open Access Digital Library
od 2015-01-01
Medline Complete (EBSCOhost)
od 2012-11-01
Health & Medicine (ProQuest)
od 2010-01-01
ROAD: Directory of Open Access Scholarly Resources
od 2010
Springer Nature OA/Free Journals
od 2010-12-01
- MeSH
- dítě MeSH
- dospělí MeSH
- genetická variace MeSH
- genové regulační sítě MeSH
- kojenec MeSH
- lidé středního věku MeSH
- lidé MeSH
- meduloblastom genetika MeSH
- mladiství MeSH
- mladý dospělý MeSH
- nádory mozečku genetika MeSH
- předškolní dítě MeSH
- proteiny hedgehog genetika MeSH
- regulace genové exprese u nádorů * MeSH
- signální transdukce genetika MeSH
- transkriptom * MeSH
- Check Tag
- dítě MeSH
- dospělí MeSH
- kojenec MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladiství MeSH
- mladý dospělý MeSH
- mužské pohlaví MeSH
- předškolní dítě MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Research Support, N.I.H., Extramural MeSH
Sonic hedgehog medulloblastoma encompasses a clinically and molecularly diverse group of cancers of the developing central nervous system. Here, we use unbiased sequencing of the transcriptome across a large cohort of 250 tumors to reveal differences among molecular subtypes of the disease, and demonstrate the previously unappreciated importance of non-coding RNA transcripts. We identify alterations within the cAMP dependent pathway (GNAS, PRKAR1A) which converge on GLI2 activity and show that 18% of tumors have a genetic event that directly targets the abundance and/or stability of MYCN. Furthermore, we discover an extensive network of fusions in focally amplified regions encompassing GLI2, and several loss-of-function fusions in tumor suppressor genes PTCH1, SUFU and NCOR1. Molecular convergence on a subset of genes by nucleotide variants, copy number aberrations, and gene fusions highlight the key roles of specific pathways in the pathogenesis of Sonic hedgehog medulloblastoma and open up opportunities for therapeutic intervention.
2nd Department of Pediatrics Semmelweis University Budapest Hungary
Adaptive Oncology Ontario Institute for Cancer Research Toronto ON Canada
Alberta Children's Hospital Research Institute Calgary AB Canada
Canada's Michael Smith Genome Sciences Centre BC Cancer Agency Vancouver BC Canada
Cancer Research Program Research Institute of the McGill University Health Centre Montreal QC Canada
Charbonneau Cancer Institute University of Calgary Calgary AB Canada
Clinical Research Division Fred Hutchinson Cancer Research Center Seattle WA United States
Computational Biology Program Ontario Institute for Cancer Research Toronto ON Canada
Department of Cell and Systems Biology University of Toronto Toronto ON Canada
Department of Human Genetics McGill University Montreal QC Canada
Department of Laboratory Medicine and Pathobiology University of Toronto Toronto ON Canada
Department of Laboratory Medicine and Pathology Mayo Clinic Rochester MN United States
Department of Medical Biophysics University of Toronto Toronto ON Canada
Department of Medical Genetics University of British Columbia Vancouver BC Canada
Department of Molecular Biology and Biochemistry Simon Fraser University Burnaby BC Canada
Department of Molecular Genetics University of Toronto Toronto ON Canada
Department of Neurological Surgery Vanderbilt Medical Center Nashville TN United States
Department of Neurology Erasmus University Medical Center Rotterdam Netherlands
Department of Neurology University of California San Francisco San Francisco CA United States
Department of Neurology Vanderbilt Medical Center Nashville TN United States
Department of Neurosurgery Duke University Durham NC United States
Department of Neurosurgery Kitasato University School of Medicine Sagamihara Kanagawa Japan
Department of Neurosurgery University of Alabama at Birmingham Birmingham AL United States
Department of Neurosurgery University of Debrecen Medical and Health Science Centre Debrecen Hungary
Department of Neurosurgery University of Ulsan Asan Medical Center Seoul South Korea
Department of Pathology and Laboratory Medicine Hamilton General Hospital Hamilton ON Canada
Department of Pathology Duke University Durham NC United States
Department of Pathology Erasmus University Medical Center Rotterdam Netherlands
Department of Pathology The Children's Memorial Health Institute Warsaw Poland
Department of Pathology University of California San Francisco San Francisco CA United States
Department of Pathology University of Pittsburgh School of Medicine Pittsburgh PA United States
Department of Pediatric Oncology Masaryk University School of Medicine Brno Czech Republic
Department of Pediatrics University of California San Francisco San Francisco CA United States
Department of Pediatrics University of Colorado Denver Aurora CO United States
Department of Surgery The Chinese University of Hong Kong Shatin New Territories Hong Kong
Department of Surgery University of Toronto Toronto ON Canada
Developmental and Stem Cell Biology Program The Hospital for Sick Children Toronto ON Canada
Division of Experimental Medicine McGill University Montreal QC Canada
Division of Neurosurgery Centro Hospitalar Lisboa Norte Hospital de Santa Maria Lisbon Portugal
Division of Neurosurgery The Hospital for Sick Children Toronto ON Canada
Division of Neurosurgery Toronto Western Hospital University Health Network Toronto ON Canada
Division of Pediatric Hematology Oncology Mayo Clinic Rochester MN United States
Division of Stem Cell Research Institute for Clinical Research Osaka National Hospital Osaka Japan
INSERM U 830 Institut Curie Paris France
Institute of Medical Science University of Toronto Toronto ON Canada
Institute of Neuropathology University Medical Center Hamburg Eppendorf Germany
McGill University Genome Centre McGill University Montreal QC Canada
Pediatric Hematology and Oncology University Medical Center Hamburg Eppendorf Germany
Research Institute Children's Cancer Center Hamburg Germany
SIREDO Center Institut Curie University of Paris Paris France
The Donnelly Centre University of Toronto Toronto ON Canada
Citace poskytuje Crossref.org
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