Detail
Článek
Článek online
FT
Medvik - BMČ
  • Je něco špatně v tomto záznamu ?

Structure Elucidation and Cholinesterase Inhibition Activity of Two New Minor Amaryllidaceae Alkaloids

J. Maříková, AA. Mamun, LA. Shammari, J. Korábečný, T. Kučera, D. Hulcová, J. Kuneš, M. Malaník, M. Vašková, E. Kohelová, L. Nováková, L. Cahlíková, M. Pour

. 2021 ; 26 (5) : . [pub] 20210226

Jazyk angličtina Země Švýcarsko

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc21019196

Grantová podpora
SVV UK 260 548, SVV UK 260 547 Grantová Agentura, Univerzita Karlova
VT2019-2021 University Hradec Králové
00179906 University Hospital Hradec Kralove
CZ.02.1.01/0.0/0.0/16_019/0000841 European Regional Development Fund

Two new minor Amaryllidaceae alkaloids were isolated from Hippeastrum × hybridum cv. Ferrari and Narcissus pseudonarcissus cv. Carlton. The chemical structures were identified by various spectroscopic (one- and two-dimensional (1D and 2D) NMR, circular dichroism (CD), high-resolution mass spectrometry (HRMS) and by comparison with literature data of similar compounds. Both isolated alkaloids were screened for their human acetylcholinesterase (hAChE) and butyrylcholinesterase (hBuChE) inhibition activity. One of the new compounds, a heterodimer alkaloid of narcikachnine-type, named narciabduliine (2), showed balanced inhibition potency for both studied enzymes, with IC50 values of 3.29 ± 0.73 µM for hAChE and 3.44 ± 0.02 µM for hBuChE. The accommodation of 2 into the active sites of respective enzymes was predicted using molecular modeling simulation.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc21019196
003      
CZ-PrNML
005      
20210830100751.0
007      
ta
008      
210728s2021 sz f 000 0|eng||
009      
AR
024    7_
$a 10.3390/molecules26051279 $2 doi
035    __
$a (PubMed)33652925
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a sz
100    1_
$a Maříková, Jana $u Department of Bioorganic and Organic Chemistry, Faculty of Pharmacy, Charles University, Heyrovskeho 1203, 500 05 Hradec Kralove, Czech Republic
245    10
$a Structure Elucidation and Cholinesterase Inhibition Activity of Two New Minor Amaryllidaceae Alkaloids / $c J. Maříková, AA. Mamun, LA. Shammari, J. Korábečný, T. Kučera, D. Hulcová, J. Kuneš, M. Malaník, M. Vašková, E. Kohelová, L. Nováková, L. Cahlíková, M. Pour
520    9_
$a Two new minor Amaryllidaceae alkaloids were isolated from Hippeastrum × hybridum cv. Ferrari and Narcissus pseudonarcissus cv. Carlton. The chemical structures were identified by various spectroscopic (one- and two-dimensional (1D and 2D) NMR, circular dichroism (CD), high-resolution mass spectrometry (HRMS) and by comparison with literature data of similar compounds. Both isolated alkaloids were screened for their human acetylcholinesterase (hAChE) and butyrylcholinesterase (hBuChE) inhibition activity. One of the new compounds, a heterodimer alkaloid of narcikachnine-type, named narciabduliine (2), showed balanced inhibition potency for both studied enzymes, with IC50 values of 3.29 ± 0.73 µM for hAChE and 3.44 ± 0.02 µM for hBuChE. The accommodation of 2 into the active sites of respective enzymes was predicted using molecular modeling simulation.
650    _2
$a alkaloidy $x chemie $x farmakologie $7 D000470
650    _2
$a Alzheimerova nemoc $7 D000544
650    _2
$a alkaloidy amarylkovitých $x chemie $x farmakologie $7 D047151
650    _2
$a butyrylcholinesterasa $x chemie $x ultrastruktura $7 D002091
650    _2
$a katalytická doména $x účinky léků $7 D020134
650    _2
$a cholinesterasové inhibitory $x chemie $x farmakologie $7 D002800
650    _2
$a cholinesterasy $x chemie $x ultrastruktura $7 D002802
650    _2
$a cirkulární dichroismus $7 D002942
650    _2
$a lidé $7 D006801
650    _2
$a simulace molekulového dockingu $7 D062105
650    _2
$a molekulární struktura $7 D015394
650    _2
$a vztahy mezi strukturou a aktivitou $7 D013329
655    _2
$a časopisecké články $7 D016428
700    1_
$a Mamun, Abdullah Al $u ADINACO Research Group, Department of Pharmaceutical Botany, Faculty of Pharmacy, Charles University, Heyrovskeho 1203, 500 05 Hradec Kralove, Czech Republic
700    1_
$a Shammari, Latifah Al $u ADINACO Research Group, Department of Pharmaceutical Botany, Faculty of Pharmacy, Charles University, Heyrovskeho 1203, 500 05 Hradec Kralove, Czech Republic
700    1_
$a Korábečný, Jan $u Department of Toxicology and Military Pharmacy, University of Defence, Trenesska 1575, 500 05 Hradec Kralove, Czech Republic $u Biomedical Research Centre, University Hospital Hradec Králové, Sokolska 581, 500 05 Hradec Kralove, Czech Republic
700    1_
$a Kučera, Tomáš $u Department of Toxicology and Military Pharmacy, University of Defence, Trenesska 1575, 500 05 Hradec Kralove, Czech Republic
700    1_
$a Hulcová, Daniela $u ADINACO Research Group, Department of Pharmaceutical Botany, Faculty of Pharmacy, Charles University, Heyrovskeho 1203, 500 05 Hradec Kralove, Czech Republic $u Department of Pharmacognosy, Faculty of Pharmacy, Charles University, Heyrovskeho 1203, 500 05 Hradec Kralove, Czech Republic
700    1_
$a Kuneš, Jiří $u Department of Bioorganic and Organic Chemistry, Faculty of Pharmacy, Charles University, Heyrovskeho 1203, 500 05 Hradec Kralove, Czech Republic
700    1_
$a Malaník, Milan $u Department of Natural Drugs, Faculty of Pharmacy, Masaryk University, Palackeho trida 1946/1, 612 00 Brno, Czech Republic
700    1_
$a Vašková, Michaela $u Department of Chemistry, Faculty of Science, University of Hradec Kralove, Rokitanskeho 62, 500 03 Hradec Kralove, Czech Republic
700    1_
$a Kohelová, Eliška $u ADINACO Research Group, Department of Pharmaceutical Botany, Faculty of Pharmacy, Charles University, Heyrovskeho 1203, 500 05 Hradec Kralove, Czech Republic
700    1_
$a Nováková, Lucie $u Department of Analytical Chemistry, Faculty of Pharmacy, Charles University, Heyrovskeho 1203, 500 05 Hradec Kralove, Czech Republic
700    1_
$a Cahlíková, Lucie $u ADINACO Research Group, Department of Pharmaceutical Botany, Faculty of Pharmacy, Charles University, Heyrovskeho 1203, 500 05 Hradec Kralove, Czech Republic
700    1_
$a Pour, Milan $u Department of Bioorganic and Organic Chemistry, Faculty of Pharmacy, Charles University, Heyrovskeho 1203, 500 05 Hradec Kralove, Czech Republic
773    0_
$w MED00180394 $t Molecules (Basel, Switzerland) $x 1420-3049 $g Roč. 26, č. 5 (2021)
856    41
$u https://pubmed.ncbi.nlm.nih.gov/33652925 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y p $z 0
990    __
$a 20210728 $b ABA008
991    __
$a 20210830100751 $b ABA008
999    __
$a ok $b bmc $g 1690101 $s 1139642
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2021 $b 26 $c 5 $e 20210226 $i 1420-3049 $m Molecules $n Molecules $x MED00180394
GRA    __
$a SVV UK 260 548, SVV UK 260 547 $p Grantová Agentura, Univerzita Karlova
GRA    __
$a VT2019-2021 $p University Hradec Králové
GRA    __
$a 00179906 $p University Hospital Hradec Kralove
GRA    __
$a CZ.02.1.01/0.0/0.0/16_019/0000841 $p European Regional Development Fund
LZP    __
$a Pubmed-20210728

Najít záznam

Citační ukazatele

Pouze přihlášení uživatelé

Možnosti archivace