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Vitamin C-Sources, Physiological Role, Kinetics, Deficiency, Use, Toxicity, and Determination

M. Doseděl, E. Jirkovský, K. Macáková, LK. Krčmová, L. Javorská, J. Pourová, L. Mercolini, F. Remião, L. Nováková, P. Mladěnka, . On Behalf Of The Oemonom

. 2021 ; 13 (2) : . [pub] 20210213

Jazyk angličtina Země Švýcarsko

Typ dokumentu časopisecké články, přehledy

Perzistentní odkaz   https://www.medvik.cz/link/bmc21019252

Grantová podpora
2020-1-CZ01-KA203-078218 Erasmus+ Programme
CZ.02.1.01/0.0/0.0/16_019/0000841 EFSA-CDN
00179906 MH-CZ-DRO

Vitamin C (L-ascorbic acid) has been known as an antioxidant for most people. However, its physiological role is much larger and encompasses very different processes ranging from facilitation of iron absorption through involvement in hormones and carnitine synthesis for important roles in epigenetic processes. Contrarily, high doses act as a pro-oxidant than an anti-oxidant. This may also be the reason why plasma levels are meticulously regulated on the level of absorption and excretion in the kidney. Interestingly, most cells contain vitamin C in millimolar concentrations, which is much higher than its plasma concentrations, and compared to other vitamins. The role of vitamin C is well demonstrated by miscellaneous symptoms of its absence-scurvy. The only clinically well-documented indication for vitamin C is scurvy. The effects of vitamin C administration on cancer, cardiovascular diseases, and infections are rather minor or even debatable in the general population. Vitamin C is relatively safe, but caution should be given to the administration of high doses, which can cause overt side effects in some susceptible patients (e.g., oxalate renal stones). Lastly, analytical methods for its determination with advantages and pitfalls are also discussed in this review.

Citace poskytuje Crossref.org

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