• Je něco špatně v tomto záznamu ?

Axonal Organelles as Molecular Platforms for Axon Growth and Regeneration after Injury

V. Petrova, B. Nieuwenhuis, JW. Fawcett, R. Eva

. 2021 ; 22 (4) : . [pub] 20210211

Jazyk angličtina Země Švýcarsko

Typ dokumentu časopisecké články, přehledy

Perzistentní odkaz   https://www.medvik.cz/link/bmc21019261

Grantová podpora
MR/R004463/1 Medical Research Council - United Kingdom
CZ.02.1.01/0.0./0.0/ 15_003/0000419 Czech Ministry of Education
MR/R004544/1 Medical Research Council - United Kingdom
RG88062 International Foundation for Research in Paraplegia

Investigating the molecular mechanisms governing developmental axon growth has been a useful approach for identifying new strategies for boosting axon regeneration after injury, with the goal of treating debilitating conditions such as spinal cord injury and vision loss. The picture emerging is that various axonal organelles are important centers for organizing the molecular mechanisms and machinery required for growth cone development and axon extension, and these have recently been targeted to stimulate robust regeneration in the injured adult central nervous system (CNS). This review summarizes recent literature highlighting a central role for organelles such as recycling endosomes, the endoplasmic reticulum, mitochondria, lysosomes, autophagosomes and the proteasome in developmental axon growth, and describes how these organelles can be targeted to promote axon regeneration after injury to the adult CNS. This review also examines the connections between these organelles in developing and regenerating axons, and finally discusses the molecular mechanisms within the axon that are required for successful axon growth.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc21019261
003      
CZ-PrNML
005      
20210830100836.0
007      
ta
008      
210728s2021 sz f 000 0|eng||
009      
AR
024    7_
$a 10.3390/ijms22041798 $2 doi
035    __
$a (PubMed)33670312
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a sz
100    1_
$a Petrova, Veselina $u John van Geest Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, Cambridge CB2 0PY, UK
245    10
$a Axonal Organelles as Molecular Platforms for Axon Growth and Regeneration after Injury / $c V. Petrova, B. Nieuwenhuis, JW. Fawcett, R. Eva
520    9_
$a Investigating the molecular mechanisms governing developmental axon growth has been a useful approach for identifying new strategies for boosting axon regeneration after injury, with the goal of treating debilitating conditions such as spinal cord injury and vision loss. The picture emerging is that various axonal organelles are important centers for organizing the molecular mechanisms and machinery required for growth cone development and axon extension, and these have recently been targeted to stimulate robust regeneration in the injured adult central nervous system (CNS). This review summarizes recent literature highlighting a central role for organelles such as recycling endosomes, the endoplasmic reticulum, mitochondria, lysosomes, autophagosomes and the proteasome in developmental axon growth, and describes how these organelles can be targeted to promote axon regeneration after injury to the adult CNS. This review also examines the connections between these organelles in developing and regenerating axons, and finally discusses the molecular mechanisms within the axon that are required for successful axon growth.
650    _2
$a zvířata $7 D000818
650    _2
$a růstové kužele $x metabolismus $x patologie $7 D020439
650    _2
$a lidé $7 D006801
650    12
$a regenerace nervu $7 D009416
650    _2
$a organely $x metabolismus $x patologie $7 D015388
650    12
$a poranění míchy $x metabolismus $x patologie $x terapie $7 D013119
655    _2
$a časopisecké články $7 D016428
655    _2
$a přehledy $7 D016454
700    1_
$a Nieuwenhuis, Bart $u John van Geest Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, Cambridge CB2 0PY, UK $u Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 0XY, UK
700    1_
$a Fawcett, James W $u John van Geest Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, Cambridge CB2 0PY, UK $u Centre for Reconstructive Neuroscience, Institute of Experimental Medicine CAS, 142 20 Prague, Czech Republic
700    1_
$a Eva, Richard $u John van Geest Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, Cambridge CB2 0PY, UK
773    0_
$w MED00176142 $t International journal of molecular sciences $x 1422-0067 $g Roč. 22, č. 4 (2021)
856    41
$u https://pubmed.ncbi.nlm.nih.gov/33670312 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y p $z 0
990    __
$a 20210728 $b ABA008
991    __
$a 20210830100836 $b ABA008
999    __
$a ok $b bmc $g 1690154 $s 1139707
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2021 $b 22 $c 4 $e 20210211 $i 1422-0067 $m International journal of molecular sciences $n Int J Mol Sci $x MED00176142
GRA    __
$a MR/R004463/1 $p Medical Research Council $2 United Kingdom
GRA    __
$a CZ.02.1.01/0.0./0.0/ 15_003/0000419 $p Czech Ministry of Education
GRA    __
$a MR/R004544/1 $p Medical Research Council $2 United Kingdom
GRA    __
$a RG88062 $p International Foundation for Research in Paraplegia
LZP    __
$a Pubmed-20210728

Najít záznam

Citační ukazatele

Možnosti archivace