• Je něco špatně v tomto záznamu ?

Expression of Opioid Receptors in Cells of the Immune System

J. Brejchova, V. Holan, P. Svoboda

. 2020 ; 22 (1) : . [pub] 20201230

Jazyk angličtina Země Švýcarsko

Typ dokumentu časopisecké články, přehledy

Perzistentní odkaz   https://www.medvik.cz/link/bmc21019611

Grantová podpora
LTAUSA18110 Ministerstvo Školství, Mládeže a Tělovýchovy
19-02290S Grantová Agentura České Republiky

The observation of the immunomodulatory effects of opioid drugs opened the discussion about possible mechanisms of action and led researchers to consider the presence of opioid receptors (OR) in cells of the immune system. To date, numerous studies analyzing the expression of OR subtypes in animal and human immune cells have been performed. Some of them confirmed the expression of OR at both the mRNA and protein level, while others did not detect the receptor mRNA either. Although this topic remains controversial, further studies are constantly being published. The most recent articles suggested that the expression level of OR in human peripheral blood lymphocytes could help to evaluate the success of methadone maintenance therapy in former opioid addicts, or could serve as a biomarker for chronic pain diagnosis. However, the applicability of these findings to clinical practice needs to be verified by further investigations.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc21019611
003      
CZ-PrNML
005      
20210830101208.0
007      
ta
008      
210728s2020 sz f 000 0|eng||
009      
AR
024    7_
$a 10.3390/ijms22010315 $2 doi
035    __
$a (PubMed)33396783
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a sz
100    1_
$a Brejchova, Jana $u Laboratory of Biomathematics, Institute of Physiology of the Czech Academy of Sciences, 14220 Prague, Czech Republic
245    10
$a Expression of Opioid Receptors in Cells of the Immune System / $c J. Brejchova, V. Holan, P. Svoboda
520    9_
$a The observation of the immunomodulatory effects of opioid drugs opened the discussion about possible mechanisms of action and led researchers to consider the presence of opioid receptors (OR) in cells of the immune system. To date, numerous studies analyzing the expression of OR subtypes in animal and human immune cells have been performed. Some of them confirmed the expression of OR at both the mRNA and protein level, while others did not detect the receptor mRNA either. Although this topic remains controversial, further studies are constantly being published. The most recent articles suggested that the expression level of OR in human peripheral blood lymphocytes could help to evaluate the success of methadone maintenance therapy in former opioid addicts, or could serve as a biomarker for chronic pain diagnosis. However, the applicability of these findings to clinical practice needs to be verified by further investigations.
650    _2
$a opioidní analgetika $x farmakologie $7 D000701
650    _2
$a zvířata $7 D000818
650    _2
$a biologické markery $7 D015415
650    _2
$a chronická bolest $x farmakoterapie $x etiologie $x metabolismus $7 D059350
650    12
$a regulace genové exprese $7 D005786
650    _2
$a lidé $7 D006801
650    _2
$a imunitní systém $x účinky léků $x imunologie $x metabolismus $7 D007107
650    _2
$a zánět $x komplikace $x etiologie $x metabolismus $7 D007249
650    _2
$a receptory opiátové $x genetika $x metabolismus $7 D011957
650    _2
$a kmenové buňky $x účinky léků $x metabolismus $7 D013234
655    _2
$a časopisecké články $7 D016428
655    _2
$a přehledy $7 D016454
700    1_
$a Holan, Vladimir $u Department of Nanotoxicology and Molecular Epidemiology, Institute of Experimental Medicine of the Czech Academy of Sciences, 14220 Prague, Czech Republic $u Department of Cell Biology, Faculty of Science, Charles University, 12843 Prague, Czech Republic
700    1_
$a Svoboda, Petr $u Laboratory of Biomathematics, Institute of Physiology of the Czech Academy of Sciences, 14220 Prague, Czech Republic
773    0_
$w MED00176142 $t International journal of molecular sciences $x 1422-0067 $g Roč. 22, č. 1 (2020)
856    41
$u https://pubmed.ncbi.nlm.nih.gov/33396783 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y p $z 0
990    __
$a 20210728 $b ABA008
991    __
$a 20210830101208 $b ABA008
999    __
$a ok $b bmc $g 1690437 $s 1140057
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2020 $b 22 $c 1 $e 20201230 $i 1422-0067 $m International journal of molecular sciences $n Int J Mol Sci $x MED00176142
GRA    __
$a LTAUSA18110 $p Ministerstvo Školství, Mládeže a Tělovýchovy
GRA    __
$a 19-02290S $p Grantová Agentura České Republiky
LZP    __
$a Pubmed-20210728

Najít záznam

Citační ukazatele

Možnosti archivace