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The Arg753Gln Polymorphism of Toll-Like Receptor 2 Has a Lower Occurrence in Patients with Syphilis, Suggesting Its Protective Effect in Czech and Slovak Individuals
L. Grillová, J. Musilová, K. Janečková, P. Pospíšilová, I. Kuklová, V. Woznicová, H. Zákoucká, D. Šmajs
Language English Country United States
Document type Journal Article, Research Support, Non-U.S. Gov't
Grant support
NV17-31333A
MZ0
CEP Register
Digital library NLK
Full text - Article
NLK
Free Medical Journals
from 1970 to 6 months ago
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from 1995 to 6 months ago
PubMed Central
from 1970 to 6 months ago
Europe PubMed Central
from 1970 to 6 months ago
Open Access Digital Library
from 1970-01-01
Open Access Digital Library
from 1970-01-01
PubMed
33077622
DOI
10.1128/iai.00503-20
Knihovny.cz E-resources
- MeSH
- Alleles MeSH
- Adult MeSH
- Gene Frequency MeSH
- Genetic Predisposition to Disease * MeSH
- Genotype MeSH
- Polymorphism, Single Nucleotide * MeSH
- Middle Aged MeSH
- Humans MeSH
- Adolescent MeSH
- Young Adult MeSH
- Case-Control Studies MeSH
- Amino Acid Substitution * MeSH
- Syphilis epidemiology etiology MeSH
- Toll-Like Receptor 2 genetics MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Adolescent MeSH
- Young Adult MeSH
- Male MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Geographicals
- Czech Republic MeSH
- Slovakia MeSH
Syphilis is a bacterial infection caused by Treponema pallidum subsp. pallidum Infection with T. pallidum subsp. pallidum and its dissemination lead to the synthesis of proinflammatory cytokines triggered by the interaction of bacterial lipoproteins with Toll-like receptor 2 (TLR2). TLR2 contains several nonsynonymous single-nucleotide polymorphisms that may impact the activation of its signaling cascade and alter the responsiveness to, or the course of, various infectious diseases, including those caused by pathogenic spirochetes. To investigate whether TLR2 polymorphism may influence susceptibility to syphilis, 221 healthy individuals with no history of syphilis (controls) and 137 patients diagnosed with syphilis (cases) were screened for the presence of the Arg753Gln polymorphism in the TLR2 gene (2258G→A; rs5743708). The Arg753Gln variant occurs at a significantly lower frequency in syphilis patients (4 of 137 [3%]) than in controls (24 of 221 [10.9%]). These data suggest that TLR2 Arg753Gln may protect from the development of syphilis due to reduced signaling.
Department of Biology Faculty of Medicine Masaryk University Brno Czech Republic
Department of Dermatology 1st Faculty of Medicine Charles University Prague Prague Czech Republic
Department of Medical Microbiology Faculty of Medicine Masaryk University Brno Czech Republic
References provided by Crossref.org
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- $a Syphilis is a bacterial infection caused by Treponema pallidum subsp. pallidum Infection with T. pallidum subsp. pallidum and its dissemination lead to the synthesis of proinflammatory cytokines triggered by the interaction of bacterial lipoproteins with Toll-like receptor 2 (TLR2). TLR2 contains several nonsynonymous single-nucleotide polymorphisms that may impact the activation of its signaling cascade and alter the responsiveness to, or the course of, various infectious diseases, including those caused by pathogenic spirochetes. To investigate whether TLR2 polymorphism may influence susceptibility to syphilis, 221 healthy individuals with no history of syphilis (controls) and 137 patients diagnosed with syphilis (cases) were screened for the presence of the Arg753Gln polymorphism in the TLR2 gene (2258G→A; rs5743708). The Arg753Gln variant occurs at a significantly lower frequency in syphilis patients (4 of 137 [3%]) than in controls (24 of 221 [10.9%]). These data suggest that TLR2 Arg753Gln may protect from the development of syphilis due to reduced signaling.
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