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ROS-generation and cellular uptake behavior of amino-silica nanoparticles arisen from their uploading by both iron-oxides and hexamolybdenum clusters

S. Fedorenko, J. Elistratova, A. Stepanov, A. Khazieva, M. Mikhailov, M. Sokolov, K. Kholin, I. Nizameev, R. Mendes, M. Rümmeli, T. Gemming, B. Weise, L. Giebeler, D. Mikhailova, S. Dutz, D. Zahn, A. Voloshina, A. Sapunova, A. Daminova, S....

. 2020 ; 117 (-) : 111305. [pub] 20200728

Language English Country Netherlands

Document type Journal Article

Persistent link   https://www.medvik.cz/link/bmc21019755

The present work introduces combination of superparamagnetic iron oxides (SPIONs) and hexamolybdenum cluster ([{Mo6I8}I6]2-) units within amino-decorated silica nanoparticles (SNs) as promising design of the hybrid SNs as efficient cellular contrast and therapeutic agents. The heating generated by SNs doped with SPIONs (Fe3O4@SNs) under alternating magnetic field is characterized by high specific absorption rate (SAR = 446 W/g). The cluster units deposition onto both Fe3O4@SNs and "empty" silica nanoparticles (SNs) results in Fe3O4@SNs[{Mo6I8}I6] and SNs[{Mo6I8}I6] with red cluster-centered luminescence and ability to generate reactive oxygen species (ROS) under the irradiation. The monitoring of spin-trapped ROS by ESR spectroscopy technique indicates that the ROS-generation decreases in time for SNs[{Mo6I8}I6] and [{Mo6I8}I6]2- in aqueous solutions, while it remains constant for Fe3O4@SNs[{Mo6I8}I6]. The cytotoxicity is low for both Fe3O4@SNs[{Mo6I8}I6] and SNs[{Mo6I8}I6], while the flow cytometry indicates preferable cellular uptake of the former versus the latter type of the nanoparticles. Moreover, entering into nucleus along with cytoplasm differentiates the intracellular distribution of Fe3O4@SNs[{Mo6I8}I6] from that of SNs[{Mo6I8}I6], which remain in the cell cytoplasm only. The exceptional behavior of Fe3O4@SNs[{Mo6I8}I6] is explained by residual amounts of iron ions at the silica surface.

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$a Fedorenko, Svetlana $u Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center of RAS, Arbuzov str., 8, 420088 Kazan, Russia. Electronic address: svetlana@iopc.ru
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$a ROS-generation and cellular uptake behavior of amino-silica nanoparticles arisen from their uploading by both iron-oxides and hexamolybdenum clusters / $c S. Fedorenko, J. Elistratova, A. Stepanov, A. Khazieva, M. Mikhailov, M. Sokolov, K. Kholin, I. Nizameev, R. Mendes, M. Rümmeli, T. Gemming, B. Weise, L. Giebeler, D. Mikhailova, S. Dutz, D. Zahn, A. Voloshina, A. Sapunova, A. Daminova, S. Fedosimova, A. Mustafina
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$a The present work introduces combination of superparamagnetic iron oxides (SPIONs) and hexamolybdenum cluster ([{Mo6I8}I6]2-) units within amino-decorated silica nanoparticles (SNs) as promising design of the hybrid SNs as efficient cellular contrast and therapeutic agents. The heating generated by SNs doped with SPIONs (Fe3O4@SNs) under alternating magnetic field is characterized by high specific absorption rate (SAR = 446 W/g). The cluster units deposition onto both Fe3O4@SNs and "empty" silica nanoparticles (SNs) results in Fe3O4@SNs[{Mo6I8}I6] and SNs[{Mo6I8}I6] with red cluster-centered luminescence and ability to generate reactive oxygen species (ROS) under the irradiation. The monitoring of spin-trapped ROS by ESR spectroscopy technique indicates that the ROS-generation decreases in time for SNs[{Mo6I8}I6] and [{Mo6I8}I6]2- in aqueous solutions, while it remains constant for Fe3O4@SNs[{Mo6I8}I6]. The cytotoxicity is low for both Fe3O4@SNs[{Mo6I8}I6] and SNs[{Mo6I8}I6], while the flow cytometry indicates preferable cellular uptake of the former versus the latter type of the nanoparticles. Moreover, entering into nucleus along with cytoplasm differentiates the intracellular distribution of Fe3O4@SNs[{Mo6I8}I6] from that of SNs[{Mo6I8}I6], which remain in the cell cytoplasm only. The exceptional behavior of Fe3O4@SNs[{Mo6I8}I6] is explained by residual amounts of iron ions at the silica surface.
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$a Elistratova, Julia $u Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center of RAS, Arbuzov str., 8, 420088 Kazan, Russia
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$a Stepanov, Alexey $u Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center of RAS, Arbuzov str., 8, 420088 Kazan, Russia
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$a Khazieva, Alsu $u Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center of RAS, Arbuzov str., 8, 420088 Kazan, Russia
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$a Mikhailov, Maksim $u Nikolaev Institute of Inorganic Chemistry, 3 Acad. Lavrentiev Prosp., Novosibirsk, Russia
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$a Sokolov, Maxim $u Nikolaev Institute of Inorganic Chemistry, 3 Acad. Lavrentiev Prosp., Novosibirsk, Russia
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$a Mendes, Rafael $u Leibniz Institute for Solid State and Materials Research (IFW) Dresden e.V., Helmholtzstr. 20, 01069 Dresden, Germany
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$a Rümmeli, Mark $u Soochow Institute for Energy and Materials Innovations, College of Physics, Optoelectronics and Energy & Collaborative Innovation Center of Suzhou Nano Science and Technology & Suzhou Key Laboratory for Advanced Carbon Materials and Wearable Energy Technologies, Soochow University, Suzhou 215006, China; Leibniz Institute for Solid State and Materials Research (IFW) Dresden e.V., Helmholtzstr. 20, 01069 Dresden, Germany; Centre of Polymer and Carbon Materials, Polish Academy of Sciences, M. Curie-Sklodowskiej 34, Zabrze 41-819, Poland; Institute of Environmental Technology, VЉB-Technical University of Ostrava, 17. listopadu 15, Ostrava 708 33, Czech Republic
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$a Gemming, Thomas $u Leibniz Institute for Solid State and Materials Research (IFW) Dresden e.V., Helmholtzstr. 20, 01069 Dresden, Germany
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$a Dutz, Silvio $u Institute of Biomedical Engineering and Informatics (BMTI), Technische Universitдt Ilmenau, Ilmenau, Germany
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$a Zahn, Diana $u Institute of Biomedical Engineering and Informatics (BMTI), Technische Universitдt Ilmenau, Ilmenau, Germany
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$a Voloshina, Alexandra $u Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center of RAS, Arbuzov str., 8, 420088 Kazan, Russia
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$a Sapunova, Anastasia $u Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center of RAS, Arbuzov str., 8, 420088 Kazan, Russia
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$a Daminova, Amina $u Kazan (Volga region) Federal University, 18 Kremlyovskaya str., 420008 Kazan, Russian Federation
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$a Fedosimova, Svetlana $u Kazan (Volga region) Federal University, 18 Kremlyovskaya str., 420008 Kazan, Russian Federation
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$a Mustafina, Asiya $u Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center of RAS, Arbuzov str., 8, 420088 Kazan, Russia
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