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Biophysical Characterization and Anticancer Activities of Photosensitive Phytoanthraquinones Represented by Hypericin and Its Model Compounds
V. Verebová, J. Beneš, J. Staničová
Language English Country Switzerland
Document type Journal Article, Review
Grant support
KEGA 012UVLF-4/2018
Ministry of Education Slovak Republic
NLK
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- MeSH
- Anthraquinones chemistry MeSH
- Photochemotherapy MeSH
- Photosensitizing Agents chemistry pharmacology MeSH
- Humans MeSH
- Neoplasms drug therapy MeSH
- Perylene analogs & derivatives chemistry pharmacology MeSH
- Antineoplastic Agents chemistry pharmacology MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Review MeSH
Photosensitive compounds found in herbs have been reported in recent years as having a variety of interesting medicinal and biological activities. In this review, we focus on photosensitizers such as hypericin and its model compounds emodin, quinizarin, and danthron, which have antiviral, antifungal, antineoplastic, and antitumor effects. They can be utilized as potential agents in photodynamic therapy, especially in photodynamic therapy (PDT) for cancer. We aimed to give a comprehensive summary of the physical and chemical properties of these interesting molecules, emphasizing their mechanism of action in relation to their different interactions with biomacromolecules, specifically with DNA.
References provided by Crossref.org
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