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Mucositis does not lead to false-positivity of the Platelia Aspergillus enzyme-linked immunosorbent assay

Z. Racil, I. Kocmanova, B. Weinbergerova, M. Toskova, J. Winterova, M. Lengerova, L. Buresova, S. Timilsina, J. Mayer

. 2010 ; 29 (7) : 851-855. [pub] 20100430

Language English Country Germany

Document type Evaluation Study, Journal Article, Research Support, Non-U.S. Gov't

Persistent link   https://www.medvik.cz/link/bmc12025757

Grant support
NS10442 MZ0 CEP Register
NS10441 MZ0 CEP Register

We are reporting a study evaluating the crossover of antigens reacting in Platelia Aspergillus (PA) enzyme-linked immunosorbent assay (ELISA) from faeces to vessels during mucositis as a possible cause of false-positivity of this test. In our series of 102 episodes of different grades of mucositis, we found strong reactivity of faeces in the PA ELISA test irrespective of the grade of mucositis, the percentage of oral food intake or the presence of total parenteral nutrition. However, none of the patients included in the study were positive in the serum (when the criterion of two samples with cut-off index of positivity [IP] > 0.5 was used).

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$a Ráčil, Zdeněk, $d 1974- $7 mzk2006354038 $u Department of Internal Medicine Hemato-Oncology, Masaryk University and University Hospital Brno, Brno, Czech Republic. zracil@fnbrno.cz
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$a Kocmanová, I. $u Department of Microbiology University Hospital Brno, Brno, Czech Republic
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$a Weinbergerová, B. $u Department of Internal Medicine Hemato-Oncology, Masaryk University and University Hospital Brno, Brno, Czech Republic
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$a Tosková, M. $u Department of Internal Medicine Hemato-Oncology, Masaryk University and University Hospital Brno, Brno, Czech Republic
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$a Winterová, J. $u Department of Internal Medicine Hemato-Oncology, Masaryk University and University Hospital Brno, Brno, Czech Republic
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$a Lengerová, M. $u Department of Internal Medicine Hemato-Oncology, Masaryk University and University Hospital Brno, Brno, Czech Republic
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$a Burešová, L. $u Institute of Biostatistics and Analyses, Faculty of Medicine and the Faculty of Science, Masaryk University, Brno, Czech Republic
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$a Timilsina, S. $u Medical Faculty, Masaryk University, Brno, Czech Republic
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