Detail
Článek
Článek online
FT
Medvik - BMČ
  • Je něco špatně v tomto záznamu ?

Differences in monocyte subsets are associated with short-term survival in patients with septic shock

M. Hortová-Kohoutková, P. Lázničková, K. Bendíčková, M. De Zuani, I. Andrejčinová, V. Tomášková, P. Suk, V. Šrámek, M. Helán, J. Frič

. 2020 ; 24 (21) : 12504-12512. [pub] 20200919

Jazyk angličtina Země Velká Británie

Typ dokumentu časopisecké články, pozorovací studie, práce podpořená grantem

Perzistentní odkaz   https://www.medvik.cz/link/bmc21019902

Sepsis is characterized by dynamic changes of the immune system resulting in deregulated inflammation and failure of homoeostasis and can escalate to septic shock. Circulating monocytes and other innate immune cells are among the first ones to recognize and clear pathogens. Monocytes have an important role in sepsis and septic shock and have been studied as potential diagnostic markers. In total, forty-two patients with septic shock were recruited and blood samples obtained within first 12 hours of ICU admission. We showed that frequency of classical and intermediate monocytes assessed at the time of admission to the intensive care unit are significantly distinct in patients with septic shock who survived longer that five days from those who died. These parameters correlate significantly with differences in serum levels of inflammatory cytokines MCP-1, IL-6, IL-8, IL-10, and IL-18, and with the proportion of helper and cytotoxic T cells. The described changes in frequency of monocyte subsets and their activation status may predict short-term septic shock survival and help with fast identification of the group of vulnerable patients, who may profit from tailored therapy.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc21019902
003      
CZ-PrNML
005      
20210830101521.0
007      
ta
008      
210728s2020 xxk f 000 0|eng||
009      
AR
024    7_
$a 10.1111/jcmm.15791 $2 doi
035    __
$a (PubMed)32949213
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xxk
100    1_
$a Hortová-Kohoutková, Marcela $u International Clinical Research Center, St. Anne's University Hospital Brno, Brno, Czech Republic
245    10
$a Differences in monocyte subsets are associated with short-term survival in patients with septic shock / $c M. Hortová-Kohoutková, P. Lázničková, K. Bendíčková, M. De Zuani, I. Andrejčinová, V. Tomášková, P. Suk, V. Šrámek, M. Helán, J. Frič
520    9_
$a Sepsis is characterized by dynamic changes of the immune system resulting in deregulated inflammation and failure of homoeostasis and can escalate to septic shock. Circulating monocytes and other innate immune cells are among the first ones to recognize and clear pathogens. Monocytes have an important role in sepsis and septic shock and have been studied as potential diagnostic markers. In total, forty-two patients with septic shock were recruited and blood samples obtained within first 12 hours of ICU admission. We showed that frequency of classical and intermediate monocytes assessed at the time of admission to the intensive care unit are significantly distinct in patients with septic shock who survived longer that five days from those who died. These parameters correlate significantly with differences in serum levels of inflammatory cytokines MCP-1, IL-6, IL-8, IL-10, and IL-18, and with the proportion of helper and cytotoxic T cells. The described changes in frequency of monocyte subsets and their activation status may predict short-term septic shock survival and help with fast identification of the group of vulnerable patients, who may profit from tailored therapy.
650    _2
$a dospělí $7 D000328
650    _2
$a senioři $7 D000368
650    _2
$a senioři nad 80 let $7 D000369
650    _2
$a cytokiny $x biosyntéza $7 D016207
650    _2
$a ženské pohlaví $7 D005260
650    _2
$a lidé $7 D006801
650    _2
$a imunofenotypizace $7 D016130
650    _2
$a mužské pohlaví $7 D008297
650    _2
$a lidé středního věku $7 D008875
650    _2
$a monocyty $x patologie $7 D009000
650    _2
$a septický šok $x imunologie $x mortalita $x patologie $7 D012772
650    _2
$a analýza přežití $7 D016019
650    _2
$a T-lymfocyty $x imunologie $7 D013601
650    _2
$a časové faktory $7 D013997
655    _2
$a časopisecké články $7 D016428
655    _2
$a pozorovací studie $7 D064888
655    _2
$a práce podpořená grantem $7 D013485
700    1_
$a Lázničková, Petra $u International Clinical Research Center, St. Anne's University Hospital Brno, Brno, Czech Republic $u Department of Biology, Faculty of Medicine, Masaryk University, Brno, Czech Republic
700    1_
$a Bendíčková, Kamila $u International Clinical Research Center, St. Anne's University Hospital Brno, Brno, Czech Republic
700    1_
$a De Zuani, Marco $u International Clinical Research Center, St. Anne's University Hospital Brno, Brno, Czech Republic
700    1_
$a Andrejčinová, Ivana $u International Clinical Research Center, St. Anne's University Hospital Brno, Brno, Czech Republic $u Department of Biology, Faculty of Medicine, Masaryk University, Brno, Czech Republic
700    1_
$a Tomášková, Veronika $u International Clinical Research Center, St. Anne's University Hospital Brno, Brno, Czech Republic $u Department of Anesthesiology and Intensive Care, Faculty of Medicine, Masaryk University, Brno, Czech Republic
700    1_
$a Suk, Pavel $u International Clinical Research Center, St. Anne's University Hospital Brno, Brno, Czech Republic $u Department of Anesthesiology and Intensive Care, Faculty of Medicine, Masaryk University, Brno, Czech Republic
700    1_
$a Šrámek, Vladimír $u Department of Anesthesiology and Intensive Care, Faculty of Medicine, Masaryk University, Brno, Czech Republic
700    1_
$a Helán, Martin $u International Clinical Research Center, St. Anne's University Hospital Brno, Brno, Czech Republic $u Department of Anesthesiology and Intensive Care, Faculty of Medicine, Masaryk University, Brno, Czech Republic
700    1_
$a Frič, Jan $u International Clinical Research Center, St. Anne's University Hospital Brno, Brno, Czech Republic $u Institute of Hematology and Blood Transfusion, Prague, Czech Republic
773    0_
$w MED00006785 $t Journal of cellular and molecular medicine $x 1582-4934 $g Roč. 24, č. 21 (2020), s. 12504-12512
856    41
$u https://pubmed.ncbi.nlm.nih.gov/32949213 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y p $z 0
990    __
$a 20210728 $b ABA008
991    __
$a 20210830101521 $b ABA008
999    __
$a ok $b bmc $g 1690662 $s 1140348
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2020 $b 24 $c 21 $d 12504-12512 $e 20200919 $i 1582-4934 $m Journal of cellular and molecular medicine $n J Cell Mol Med $x MED00006785
LZP    __
$a Pubmed-20210728

Najít záznam

Citační ukazatele

Možnosti archivace