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Genetics, prevalence, screening and confirmation of primary aldosteronism: a position statement and consensus of the Working Group on Endocrine Hypertension of The European Society of Hypertension
P. Mulatero, S. Monticone, J. Deinum, L. Amar, A. Prejbisz, MC. Zennaro, F. Beuschlein, GP. Rossi, T. Nishikawa, A. Morganti, TM. Seccia, YH. Lin, F. Fallo, J. Widimsky
Language English Country Great Britain
Document type Journal Article
- MeSH
- Aldosterone blood MeSH
- Hyperaldosteronism * diagnosis epidemiology genetics MeSH
- Hypertension MeSH
- Consensus MeSH
- Humans MeSH
- Prevalence MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
: Autonomous aldosterone overproduction represents the underlying condition of 5-10% of patients with arterial hypertension and carries a significant burden of mortality and morbidity. The diagnostic algorithm for primary aldosteronism is sequentially based on hormonal tests (screening and confirmation tests), followed by lateralization studies (adrenal CT scanning and adrenal venous sampling) to distinguish between unilateral and bilateral disease. Despite the recommendations of the Endocrine Society guideline, primary aldosteronism is largely underdiagnosed and undertreated with high between-centre heterogeneity. Experts from the European Society of Hypertension have critically reviewed the available literature and prepared a consensus document constituting two articles to summarize current knowledge on the epidemiology, diagnosis, treatment, and complications of primary aldosteronism.
Centro Fisiologia Clinica e Ipertensione Ospedale Policlinico Università di Milano Milan Italy
Department of Hypertension National Institute of Cardiology Warsaw Poland
Department of Internal Medicine Radboud University Medical Center Nijmegen Netherlands
Department of Medicine 3 University Hospital Carl Gustav Carus at the TU Dresden Dresden Germany
Department of Medicine DIMED University of Padova Padova Italy
Endocrinology and Diabetes Center Yokohama Rosai Hospital Yokohama Japan
Medizinische Klinik und Poliklinik 4 Klinikum der Universität München Munich Germany
References provided by Crossref.org
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- $a : Autonomous aldosterone overproduction represents the underlying condition of 5-10% of patients with arterial hypertension and carries a significant burden of mortality and morbidity. The diagnostic algorithm for primary aldosteronism is sequentially based on hormonal tests (screening and confirmation tests), followed by lateralization studies (adrenal CT scanning and adrenal venous sampling) to distinguish between unilateral and bilateral disease. Despite the recommendations of the Endocrine Society guideline, primary aldosteronism is largely underdiagnosed and undertreated with high between-centre heterogeneity. Experts from the European Society of Hypertension have critically reviewed the available literature and prepared a consensus document constituting two articles to summarize current knowledge on the epidemiology, diagnosis, treatment, and complications of primary aldosteronism.
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