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Research Priorities in Pediatric Asthma: Results of a Global Survey of Multiple Stakeholder Groups by the Pediatric Asthma in Real Life (PeARL) Think Tank
AG. Mathioudakis, A. Custovic, A. Deschildre, FM. Ducharme, O. Kalayci, C. Murray, AN. Garcia, W. Phipatanakul, D. Price, A. Sheikh, I. Agache, L. Bacharier, M. Bonini, JA. Castro-Rodriguez, G. De Carlo, T. Craig, Z. Diamant, W. Feleszko, D....
Language English Country United States
Document type Journal Article, Research Support, Non-U.S. Gov't
Grant support
MR/S025340/1
Medical Research Council - United Kingdom
Department of Health - United Kingdom
- MeSH
- Asthma * diagnosis epidemiology therapy MeSH
- Child MeSH
- Adult MeSH
- Humans MeSH
- Surveys and Questionnaires MeSH
- Research MeSH
- Check Tag
- Child MeSH
- Adult MeSH
- Humans MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
BACKGROUND: Pediatric asthma remains a public health challenge with enormous impact worldwide. OBJECTIVE: The aim of this study was to identify and prioritize unmet clinical needs in pediatric asthma, which could be used to guide future research and policy activities. METHODS: We first identified unmet needs through an open-question survey administered to international experts in pediatric asthma who were members of the Pediatric Asthma in Real Life Think Tank. Prioritization of topics was then achieved through a second, extensive survey with global reach, of multiple stakeholders (leading experts, researchers, clinicians, patients, policy makers, and the pharmaceutical industry). Differences across responder groups were compared. RESULTS: A total of 57 unmet clinical need topics identified by international experts were prioritized by 412 participants from 5 continents and 60 countries. Prevention of disease progression and prediction of future risk, including persistence into adulthood, emerged as the most urgent research questions. Stratified care, based on biomarkers, clinical phenotypes, the children's age, and demographics were also highly rated. The identification of minimum diagnostic criteria in different age groups, cultural perceptions of asthma, and best treatment by age group were priorities for responders from low-middle-income countries. There was good agreement across different stakeholder groups in all domains with some notable exceptions that highlight the importance of involving the whole range of stakeholders in formulation of recommendations. CONCLUSIONS: Different stakeholders agree in the majority of research and strategic (eg, prevention, personalized approach) priorities for pediatric asthma. Stakeholder diversity is crucial for highlighting divergent issues that future guidelines should consider.
Allergy and Asthma Network Vienna Va
Allergy Center CUF Descobertas Hospital Lisbon Portugal
Allergy Center CUF Infante Santo Hospital Lisbon Portugal
Allergy Department Hospital Infantil Universitario Niño Jesús Madrid Spain
Child Health Royal Aberdeen Children's Hospital and University of Aberdeen Aberdeen United Kingdom
Department of Medicine and Pediatrics Penn State University Hershey Pa
Department of Paediatrics Faculty of Medicine The Chinese University of Hong Kong Sha Tin Hong Kong
Department of Paediatrics Imperial College London London United Kingdom
Department of Paediatrics Turku University Hospital and University of Turku Turku Finland
Department of Pediatrics School of Medicine Pontifical Universidad Catolica de Chile Santiago Chile
Department of Pediatrics University of Montreal Montreal QC Canada
Department of Women's and Children's Health Karolinska Institutet Stockholm Sweden
European Federation of Allergy and Airway Diseases Patient's Associations Brussels Belgium
Faculty of Medicine Transylvania University Brasov Romania
Family Physician Airways Group of Canada University of Toronto Toronto ON Canada
Global Allergy and Asthma Patient Platform Vienna Austria
National Heart and Lung Institute Imperial College London London United Kingdom
Observational and Pragmatic Research Institute Singapore
Pediatric Allergy and Asthma Unit Hacettepe University School of Medicine Ankara Turkey
Pediatric Allergy and Immunology Children's Hospital Boston Boston Mass
Pediatric Allergy and Immunology Unit Children's Hospital Ain Shams University Cairo Egypt
Pulmonology and Allergy Unity University Hospital La Fe Valencia Spain
School of Paediatrics and Child Health University of Western Australia Perth Australia
References provided by Crossref.org
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